Results 11 to 20 of about 14,856 (220)
Synthesis of Cyclobutane Serine Analogues [PDF]
The Journal of Organic Chemistry, 2004 In this paper, we describe a thermal [2 + 2] cycloaddition involving 2-acylaminoacrylates as electron-poor acceptor alkenes, a reaction that involves a Michael-Dieckmann-type process. The reaction gives rise to a new substituted cyclobutane skeleton that can be transformed into amino acid derivatives.
Avenoza, A. +3 more
openaire +5 more sources
cis,trans,cis-1,2,3,4-Tetrakis[2-(ethylsulfanyl)phenyl]cyclobutane
IUCrData, 2016 The title cyclobutane derivative, C36H40S4, formed serendipitously through a photochemically initiated [2 + 2] cycloaddition. The asymmetric unit contains half a molecule with the 2-(ethylsulfanyl)phenyl substituents in a cis configuration, the other ...
Barbara Sohr +4 more
doaj +2 more sources
Modular and Stereoselective Synthesis of Cyclobutane β‐Amino Alcohols
Angewandte Chemie, EarlyView.Late‐stage functionalization and photoisomerization of 1,2‐azaborine leads to a general strategy for the synthesis of diversely substituted cyclobutane β‐amino alcohols. The relative stereochemistry of the resulting products is unambiguously defined by the stereospecific and stereoselective nature of the photoisomerization‐hydrogenation‐oxidation ...
Xinyu Yang +3 more
wiley +4 more sources
Cyclobutane-Derived Diamines: Synthesis and Molecular Structure
, 2016 Cyclobutane diamines (i.e., cis- and trans-1,3-diaminocyclobutane, 6-amino-3-azaspiro[3.3]heptane, and 3,6-diaminospiro[3.3]heptane) are considered as promising sterically constrained diamine building blocks for drug discovery.
Igor V. Komarov (579414) +6 more
core +5 more sources
A Novel Class of "Super-Strained" Spiro Heterocycles: Gateway to 1-Azaspiro[3.3]heptane Derivatives, and Biological Validation. [PDF]
Angew Chem Int Ed EnglA new class of “super‐strained” spiro heterocycles—spirocyclic 1‐azabicyclo[1.1.0]butanes—was synthesized via insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into substituted azirines. The stability of this new class of compounds was studied.
Natho P +9 more
europepmc +3 more sources
Dimeric cyclobutane formation under continuous flow conditions using organophotoredox catalysed [2+2]-cycloaddition [PDF]
, 2021 Radical cation-initiated dimerization of electron rich alkenes is an expedient method for the synthesis of cyclobutanes. By merging organophotoredox catalysis and continuous flow technology a batch versus continuous flow study has been performed ...
Marc, Kimber, Helena , Grantham
core +2 more sources
A Unified and Bio-inspired Total Syntheses of Cochlearol B and Ganocins A-C via a Cyclobutane as Overbred Intermedi-ate [PDF]
, 2022 Cochlearol B and Ganocins A-C are polycyclic meroterpenoids isolated from Ganoderma cochlear with renoprotective effect and as AChE inhibitor, respectively.
Huachao, Wang +7 more
core +1 more source
Cyclobutane serine amino acid derivatives as 5-hydroxyproline precursors [PDF]
, 2010 The synthesis of the 5-hydroxyproline derivatives 3a and 3b using cyclobutane serine analogs 1 and 2 as starting materials is reported. This process occurs with moderate cis/trans selectivity. A mechanism for this reaction is also proposed.
Peregrina, J.M. [0000-0003-3778-7065] +4 more
core +3 more sources
Molecules, 2022 The ditopic halogen-bond (X-bond) donors 1,2-, 1,3-, and 1,4-diiodotetrafluorobenzene (1,2-, 1,3-, and 1,4-di-I-tFb, respectively) form binary cocrystals with the unsymmetrical ditopic X-bond acceptor trans-1-(2-pyridyl)-2-(4-pyridyl)ethylene (2,4-bpe ...
Jay Quentin +2 more
doaj +1 more source
Журнал органічної та фармацевтичної хімії, 2023 Aim. To synthesize cyclobutane-derived amines and carboxylic acids bearing CH2F or CHF2 groups in the α position; to determine the regularities of the effect of fluoroalkyl substituents on the acid-base properties of the title compounds.
Oleksandr Demchuk, Oleksandr Grygorenko
doaj +1 more source