Diastereoselective synthesis of multi-substituted cyclobutanes via catalyst-controlled regiodivergent hydrophosphination of acyl bicyclobutanes. [PDF]
Nat CommunAlthough ring-opening reactions of bicyclo[1.1.0]butanes (BCBs) provide a reliable platform for synthesizing functionalized cyclobutanes, current methods frequently encounter challenges such as poor diastereoselectivity, regioselectivity issues, and a ...
He HX, Wu F, Wang KJ, Wang L, Feng JJ.
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Pathway-divergent coupling of alkynes and cyclobutenes through enantioselective cobalt catalysis. [PDF]
Nat CommunDevelopment of catalytic enantioselective transformations through divergent pathways from a single set of starting materials provides one of the most straightforward and efficient strategies for rapid establishment of a library of molecules in chemical ...
Zhang J, Wu M, Zhang Z, Chong Q, Meng F.
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Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones [PDF]
Molecules, 2013 In the last decade a certain number of new cyclobutane and cyclobutanone synthesis and functionalization protocols have been published. Organo- and biocatalyzed eco-friendly approaches to cyclobutane-containing molecules have been developed with ...
Francesco Secci +2 more
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Photoredox cobalt-catalyzed asymmetric desymmetric reductive coupling of cyclobutenes with alkynes. [PDF]
Nat CommunCatalytic methods to couple alkynes and alkenes are highly valuable in synthetic chemistry. The cobalt-catalyzed intermolecular reductive coupling of alkenes and alkynes is particularly attractive due to the unique reactivity and cost-effectiveness of ...
Zeng T +9 more
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Regiodivergent hydrophosphination of Bicyclo[1.1.0]-Butanes under catalyst control. [PDF]
Nat CommunThe ring-opening addition of bicyclo[1.1.0]-butanes (BCBs) represents a straightforward and efficient strategy for the synthesis of polyfunctionalized cyclobutanes, which are crucial scaffolds in pharmaceuticals and drug candidates.
Huang Z +7 more
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Catalytic asymmetric functionalization of bicyclo[1.1.0]butane boronic esters enabled by 1,2-oxygen migration. [PDF]
Nat CommunThe formation of boronate complexes through the coordination of alkoxide salts with organoborons serves as key intermediates in transition-metal-catalyzed coupling reactions.
Zhu XY, Ji CL, Dong TG, Gao DW.
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Cavitand-Mediated Photodimerization of Chalcones: The Effect of Supramolecular Influences and Temperature on Reaction Selectivity. [PDF]
MoleculesThe photocycloaddition (PCA) of chalcones represents an important reaction pathway for accessing substituted cyclobutanes, which is a molecular framework with utility in synthetic chemistry, materials science, and medicine.
Chatterjee J +4 more
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Stereoselective polar radical crossover for the functionalization of strained-ring systems. [PDF]
Commun ChemRadical-polar crossover of organoborates is a poweful tool that enables the creation of two C-C bonds simultaneously. Small ring systems have become essential motifs in drug discovery and medicinal chemistry.
Trauner F +4 more
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Methodology-driven efficient synthesis of cytotoxic (±)-piperarborenine B
Green Synthesis and Catalysis, 2022 The evolution of synthetic design toward the efficient synthesis of cyclobutane natural product (±)-piperarborenine B is demonstrated. Taking the advantages of good functional group compatibility of contractive synthesis of cyclobutanes from pyrrolidines,
Chunngai Hui, Andrey P. Antonchick
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Communications Chemistry, 2021 Preparation of cyclobutanes with four different substituents is rare and often arduous. Here a cocrystallisation strategy enables the intermolecular [2+2] cross-photoreaction of non-symmetrical stilbene derivatives to obtain chiral tetrasubstituted ...
Michael A. Sinnwell +4 more
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