Stereoselective synthesis of cyclobutanes by contraction of pyrrolidines [PDF]
, 2021 Here we report a contractive synthesis of multisubstituted cyclobutanes containing multiple stereocenters from readily accessible pyrrolidines using iodonitrene chemistry.
Brieger, L +7 more
core +2 more sources
PolyBorylated Alkenes as Energy-Transfer Reactive Groups for the Generation of polyBorylated Biradicals: Access to Multi-Borylated Cyclobutanes Combined with 1,5-HAT Event [PDF]
, 2023 While polyborylated alkenes are being recognized for their elevated status as highly valuable reagents in modern organic synthesis, allowing efficient access to a diverse array of transformations, including the formation of C–C and C–heteroatom bonds ...
Nicole, Hanania +2 more
core +1 more source
, 2023 The stereoselective synthesis of cyclobutanes that possess an array of stereocenters in a contiguous fashion has attracted the wide interest of the synthetic community.
Roger Monreal-Corona (14818063) +3 more
core +2 more sources
Pd(II)-catalyzed enantioselective C(sp3)–H arylation of cy-clopropanes and cyclobutanes guided by tertiary alkyla-mines. [PDF]
, 2021 : Strained aminomethyl-cycloalkanes are a recurrent scaffold in medicinal chemistry due to their unique structural features that give rise to a range of biological properties.
Javier, Miro +3 more
core +1 more source
NMR and Computational Studies on the Reactions of Enamines with Nitroalkenes That May Pass through Cyclobutanes [PDF]
ACS Omega, 2019 The addition of aldehyde enamines to nitroalkenes affords cyclobutanes in all solvents, with all of the pyrrolidine and proline derivatives tested by us and with all of the substrates we have examined. Depending on the temperature, concentration of water,
Alejandro Castro-Alvarez +5 more
doaj +3 more sources
Functionalized Cyclobutanes via Heck Cyclization
, 2016 Heck-type 4-exo-trig cyclization of linear 2-enol triflate-1,5-hexadienes provides functionalized methylene cyclobutanes. Intramolecular palladium coordination can initiate β-hydride elimination leading to 1,2-dimethylene cyclobutane derivatives, which ...
Johann Mulzer (1297377) +2 more
core +2 more sources
Catalytic Hypervalent Iodine Promoters Lead to Styrene Dimerization and the Formation of Tri- and Tetrasubstituted Cyclobutanes [PDF]
, 2016 We report that the use of catalytic quantities of hypervalent iodine reagents (PIDA or Dess Martin Periodinane) allows the rapid and stereoselective formation of cyclobutanes under very mild conditions.
Rosimeire Coura Barcelos +5 more
core +1 more source
Modular and Stereoselective Synthesis of Cyclobutane β‐Amino Alcohols
Angewandte Chemie, EarlyView.Late‐stage functionalization and photoisomerization of 1,2‐azaborine leads to a general strategy for the synthesis of diversely substituted cyclobutane β‐amino alcohols. The relative stereochemistry of the resulting products is unambiguously defined by the stereospecific and stereoselective nature of the photoisomerization‐hydrogenation‐oxidation ...
Xinyu Yang +3 more
wiley +2 more sources
Angewandte Chemie, EarlyView.Catalytic strain‐release ring opening and functionalizations of 1‐azabicyclo[1.1.0]butanes (ABBs) represent a promising strategy for accessing diverse azetidine products. These transformations proceed via polar pathways, radical pathways, and hybrid mechanisms that combine both.
James Shao‐Jiun Yang +1 more
wiley +2 more sources
Molecules, 2022 The ditopic halogen-bond (X-bond) donors 1,2-, 1,3-, and 1,4-diiodotetrafluorobenzene (1,2-, 1,3-, and 1,4-di-I-tFb, respectively) form binary cocrystals with the unsymmetrical ditopic X-bond acceptor trans-1-(2-pyridyl)-2-(4-pyridyl)ethylene (2,4-bpe ...
Jay Quentin +2 more
doaj +1 more source