Results 31 to 40 of about 23,086 (229)

Synthesis of novel β-aminocyclobutanecarboxylic acid derivatives by a solvent-free aza-Michael addition and subsequent ring closure [PDF]

, 2011
Novel beta-aminocyclobutanecarboxylic acid derivatives were prepared via a sequential solvent-free aza-Michael addition of benzophenone imine across 3-halopropylidenemalonates and base-induced ring closure.
Aitken, Appella, Brannock, Caine, Choudhary, Declerck, Fernandes, Fernandes, Fernandes, Frackenpohl, Fülöp, Fülöp, Gademann, Gauzy, Gauzy, Gellman, Gorrea, Hall, Imanzadeh, Izquierdo, Kiss, Krapcho, Kuhl, Lehnert, Liu, Mangelinckx, Mangelinckx, Mangelinckx, Mangelinckx, Martinek, Martín-Vilà, Mittendorf, Norbert De Kimpe, Oki, Palko, Rúa, Seebach, Seebach, Su, Sulmon, Sven Mangelinckx, Tamara Meiresonne, Torres, Trabocchi, White   +44 more
core   +1 more source

Studies on the Synthesis and Reactivity of Novel Benzofuran-2-yl-[3-Methyl-3-Phenylcyclobutyl] Methanones and their Antimicrobial Activity

Molecules, 2005
Preparation in excellent yields of cyclobutyl benzofuran-2-yl- and naphthofuran- 2-yl-ketones, the corresponding ketoximes and thiosemicarbazones, ether derivatives of the ketoximes and thiazoles derived from the thiosemicarbazones are described.
Cavit Kazaz, Alaaddin Çukurovali, Misir Ahmedzade, Murat Koca   +3 more
doaj   +1 more source

Chemical investigation of light induced DNA bipyrimidine damage and repair [PDF]

, 2011
In all organisms, genetic information is stored in DNA and RNA. Both of these macromolecules are damaged by many exogenous and endogenous events, with UV irradiation being one of the major sources of damage.
Carell, Thomas, Heil, Korbinian, Pearson, David   +2 more
core   +1 more source

Kernel learning for ligand-based virtual screening: discovery of a new PPARgamma agonist [PDF]

, 2010
Poster presentation at 5th German Conference on Cheminformatics: 23. CIC-Workshop Goslar, Germany. 8-10 November 2009 We demonstrate the theoretical and practical application of modern kernel-based machine learning methods to ligand-based virtual ...
Matthias Rupp, T Schroeter, R Steri, Ewgenij Proschak, K Hansen, H Zettl, O Rau, M Schubert-Zsilavecz, K-R Müller, Gisbert Schneider, B Henke, M Rupp, B Schölkopf, S Sonnenburg, C Rücker, O Rau   +15 more
core   +3 more sources

The Ability of Cyanobacterial Cells to Restore UV-B Radiation Induced Damage to Photosystem II is Influenced by Photolyase Dependent DNA Repair [PDF]

, 2013
Damage of DNA and Photosystem-II are among the most significant effects of UV-B irradiation in photosynthetic organisms. Both damaged DNA and Photosystem-II can be repaired, which represent important defense mechanisms against detrimental UV-B effects ...
Kós, Péter, Nagy, Csaba István, Sass, László, Vass, Imre, Vass, István-Zoltán   +4 more
core   +1 more source

Crystal structure of r-1,c-2-dibenzoyl-t-3,t-4-bis(2-nitrophenyl)cyclobutane

Acta Crystallographica Section E: Crystallographic Communications, 2017
The condensation reaction of acetophenone (1-phenylethan-1-one) with 2-nitrobenzaldehyde in the molten state yielded the expected chalcone, (E)-3-(2-nitrophenyl)-1-phenylprop-2-en-1-one, and, unexpectedly, the title compound, C30H22N2O6, which results ...
Manuel Velasco Ximello, Sylvain Bernès, Aarón Pérez-Benítez, Ulises Hernández Pareja, Angel Mendoza, Jorge R. Juárez Posadas, Jaime Vázquez Bravo   +6 more
doaj   +1 more source

Translesion synthesis in mammalian cells [PDF]

, 2006
DNA damage blocks the progression of the replication fork. In order to circumvent the damaged bases, cells employ specialized low stringency DNA polymerases, which are able to carry out translesion synthesis (TLS) past different types of damage. The five
Alan R. Lehmann, Avkin, Avkin, Bienko, Garg, Gibbs, Gibbs, Gibbs, Guo, Haracska, Hoege, Huang, Johnson, Kannouche, Kannouche, King, Lehmann, Lemontt, Ling, Maher, Masutani, Masutani, McCulloch, Murakumo, Nair, Nakajima, Nelson, Nelson, Nelson, Ogi, Ohmori, Pages, Stelter, Tissier, Vidal, Watanabe   +35 more
core   +2 more sources

Synthesis of Cyclobutane Serine Analogues

The Journal of Organic Chemistry, 2004
In this paper, we describe a thermal [2 + 2] cycloaddition involving 2-acylaminoacrylates as electron-poor acceptor alkenes, a reaction that involves a Michael-Dieckmann-type process. The reaction gives rise to a new substituted cyclobutane skeleton that can be transformed into amino acid derivatives.
Avenoza, A., Busto, J.H., Canal, N., Peregrina, J.M.   +3 more
openaire   +4 more sources

Structure and mechanism of human DNA polymerase η [PDF]

, 2010
The variant form of the human syndrome xeroderma pigmentosum (XPV) is caused by a deficiency in DNA polymerase eta (Pol eta), a DNA polymerase that enables replication through ultraviolet-induced pyrimidine dimers.
A Alt, A Mees, A Nicholls, A Scrima, AJ McCoy, AJ McCoy, Alan R. Lehmann, AR Lehmann, AT Brünger, BC Broughton, C Masutani, C Masutani, C Vonrhein, Chikahide Masutani, Christian Biertümpfel, DE Brash, DF Jarosz, DG Vassylyev, DV Bugreev, E Bassett, E Glick, F Wang, Fumio Hanaoka, H Inui, H Ling, H Ling, H Ling, H Park, H Saribasak, IW Davis, J Bauer, J Di Lucca, J Trincao, J Yao, Jae Young Lee, JH Min, K Sugasawa, L Jia, L Rey, L Wang, M Tanioka, Mark Gregory, MJ McIlwraith, P Emsley, R Kusumoto, R Kusumoto, RC Wilson, RE Johnson, RJ Kokoska, S Broyde, S Creighton, S Lone, Santiago Ramón-Maiques, SD McCulloch, SG Chaney, T Hishida, T Kawamoto, TC Terwilliger, W Kabsch, W Yang, W Yang, WA Hendrickson, Wei Yang, Y Li, Ye Zhao, Yuji Kondo, Z Otwinowski   +66 more
core   +2 more sources

Effects of Substituents on the Length of Central C(sp^3)-C(sp^3) Bond in Anthracene Photodimers and Related Molecules [PDF]

, 1986
Effects of substituents on the lengths of the central C–C single bond in the butterfly-shaped anthracene photodimers (1)–(7) and lepidopterenes (8) are studied.
Buda, Andrzej B., Choi, Chang Sun, Dougherty, Dennis A., Kaupp, Gerd, Rudziński, Jerzy M., Ōsawa, Eiji   +5 more
core   +1 more source