Results 21 to 30 of about 12,599 (260)

Dissolution Studies of Physical Mixtures of Indomethacin with Alpha- and Gamma-Cyclodextrins

Biomolecules & Biomedicine, 2010
Oral administration of indomethacin has been limited by its poor water solubility. Cyclodextrins have been recognized as potential candidates to overcome the poor solubility of indomethacin through the formation of inclusion complexes.
Edina Vranić, Alija Uzunović
doaj   +1 more source

Cyclodextrin-Based Nanosponges: Overview and Opportunities

Frontiers in Chemistry, 2022
Nanosponges are solid cross-linked polymeric nano-sized porous structures. This broad concept involves, among others, metal organic frameworks and hydrogels. The focus of this manuscript is on cyclodextrin-based nanosponges.
Gianluca Utzeri, Pedro M. C. Matias, Dina Murtinho, Artur J. M. Valente   +3 more
doaj   +1 more source

Entropy Effects in Intermolecular Associations of Crown-Ethers and Cyclodextrins with Amino Acids in Aqueous and in Non-Aqueous Media

Entropy, 2021
The analysis of the ratios of entropy and enthalpy characteristics and their contributions to the change in the Gibbs energy of intermolecular interactions of crown ethers and cyclodextrins with amino acids is carried out.
Tatyana Usacheva, Irina Terekhova, Diana Alister, Mikhail Agafonov, Natalya Kuranova, Dmitry Tyurin, Valentin Sharnin   +6 more
doaj   +1 more source

Investigation of the Interactions between the Hydrophobic Cavities of Cyclodextrins and Pullulanase

Molecules, 2011
The effects of cyclodextrins and derivatives on the activity and structure of pullulanase were investigated in this study. Our results showed that cyclodextrins and derivatives decreased the activity of pullulanase.
Zhengyu Jin, Bo Yu, Jinpeng Wang, Huanxin Zhang   +3 more
doaj   +1 more source

Rapid Study on Mefloquine Hydrochloride Complexation with Hydroxypropyl-β-Cyclodextrin and Randomly Methylated β-Cyclodextrin: Phase Diagrams, Nuclear Magnetic Resonance Analysis, and Stability Assessment

Pharmaceutics, 2023
This study investigates the complexation of mefloquine hydrochloride by cyclodextrins to improve its solubility in order to design an oral solution.
Amaury Durand, David Mathiron, Sébastien Rigaud, Florence Djedaini-Pilard, Frédéric Marçon   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Cyclodextrin-Based Delivery Systems in Cosmeceuticals: Current Advances and Future Perspectives

Biomolecules
Cyclodextrins are cyclic carbohydrates capable of forming inclusion complexes with a wide range of molecules, thereby improving their solubility, stability, and bioavailability.
Catarina Amaro, Tomasz Kowalczyk, Laurent Picot, Anna Merecz-Sadowska, Pere Verdugo, Helena Cabral-Marques, Przemysław Sitarek   +6 more
doaj   +1 more source

Recent progress in encapsulation and controlled release of pesticides based on cyclodextrin derivative carriers

Advanced Agrochem, 2022
In the context of the continuous increase in global grain production, accompanied by a large amount of investment in various pesticides, herbicides, fungicides, and other chemical pesticides.
Zhisheng Liu, Weiwei Xu, Elena G. Kovaleva, Jing Cheng, Haibing Li   +4 more
doaj   +1 more source

Cyclodextrins in Parkinson’s Disease [PDF]

Biomolecules, 2018
Parkinson’s disease is a movement disorder characterized by a progressive degeneration of dopaminergic neurons that has been object of study by the scientific community through the last decades. However, nowadays there is still no treatment to cure it, although there are drugs available, with limited efficacy, to relieve the symptoms or replenish the ...
Barros, Marisa C. F., Ribeiro, Ana C. F., Esteso, Miguel Á.   +2 more
openaire   +4 more sources