Results 61 to 70 of about 26,778 (245)
Precision Matters: Minor Concentration Deviations of DMSO May Cause Major Efficacy Shifts
Angewandte Chemie, EarlyView.Low‐concentration dimethyl sulfoxide (DMSO) has long been regarded as biologically safe in drug discovery. However, increasing DMSO from 0.1% to 0.9% reduces photosensitizer PNA‐9 particle size from 657 nm to 260 nm, enhancing endocytosis and photodynamic therapy outcomes.
Sisi Yuan +6 more
wiley +2 more sources
, 2020 International audienceCyclodextrins are cyclic oligosaccharides obtained by enzymatic degradation of starch. They are remarkable macrocyclic molecules that have led major theoretical and practical advances in chemistry, biology, biochemistry, health ...
Nadia Morin-Crini +13 more
core +1 more source
An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2
Advanced Science, EarlyView.Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu +7 more
wiley +1 more source
Unlocking environmental solutions: a review of cyclodextrins in pollutant removal
Discover EnvironmentCyclodextrins are cyclic oligosaccharides characterized by a hydrophobic interior and a hydrophilic outside linked by α-1,4 glycosidic bonds. Cyclodextrins are biodegradable and generally considered environmentally friendly. These are utilized in diverse
Tuba Urooj, Monika Mishra, Shivam Pandey
doaj +1 more source
Advanced Science, EarlyView.An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan +7 more
wiley +1 more source
, 2015 International audienceCyclodextrins associated to metal centers or cyclodextrin\textendash metal hybrids have been developed for a very long time mainly because this association was seen as potentially mimicking metallo-enzymes.
Mickaël Ménand +5 more
core +1 more source
Does the Digestibility of Cyclodextrins Influence the In Vivo Absorption of Benzo[a]pyrene in Rats? [PDF]
, 2016 An important excipient used to overcome poor solubility is cyclodextrin. However, data in the literature suggest that excessive overdosing of cyclodextrins can decrease the absorption of compounds administered with cyclodextrins, due to their lack of ...
Olesen, Niels E +3 more
core +1 more source
Bioelectrochemically Powered Out‐of‐Equilibrium Hydrogels Enable Feedback‐Regulated Functions
Advanced Science, EarlyView.A bioelectrochemically powered hydrogel operates far from equilibrium via an antagonistic redox cycle that regulates disulfide exchange within a polyrotaxane network. Coupling electrochemical mediator cycling with enzymatic feedback enables dynamic control of hydrogel mechanics and transport properties, driving glucose‐responsive insulin release with ...
Roberto Baretta, Marco Frasconi
wiley +1 more source
Role of Weak Interactions and Steric Effect in Chemosensing Using Cyclodextrins
Cyclodextrins (CDs), a family of cyclic oligosaccharides, have garnered significant attention in chemosensing applications due to their unique ability to form inclusion complexes with various guest molecules.
Koyuncu, Ayfer, Çiftçi, Fatih
core +1 more source
Fundamentals and Applications of Cyclodextrins
, 2018 International audienceCyclodextrins are natural oligosaccharides obtained from starch. They were discovered in 1891 by Villiers, and attracted major scientific and industrial interests from the late 1970s.
Sophie Fourmentin +11 more
core +1 more source