Results 51 to 60 of about 25,960 (290)

History of Cyclodextrins

, 2020
International audienceCyclodextrins are cyclic oligosaccharides obtained by enzymatic degradation of starch. They are remarkable macrocyclic molecules that have led major theoretical and practical advances in chemistry, biology, biochemistry, health ...
Nadia Morin-Crini, Eric Lichtfouse, Crini, Grégorio, Torri, Giangiacomo, Fenyvesi, Éva, Sophie Fourmentin, Fourmentin, Marc, Morin-Crini, Nadia, Grégorio Crini, Éva Fenyvesi, Lichtfouse, Eric, Marc Fourmentin, Fourmentin, Sophie, Giangiacomo Torri   +13 more
core   +1 more source

S‐Nitrosothiols as Thiol‐Protecting Groups for Controlled Thiol‐Maleimide Crosslinking of Homogeneous Soft Hydrogels

Advanced Materials, EarlyView.
Rapid thiol‐maleimide addition frequently outpaces mixing, resulting in heterogeneous hydrogels. S‐nitrosothiols act as thiol‐protecting groups, allowing uniform mixing with maleimide‐functionalized polymers before gelation. Sodium thiosulfate or sodium ascorbate then regenerates thiols on demand, triggering controlled thiol‐maleimide crosslinking ...
Julian A. Serna, Michelle J. Iwohn, Maximilian Seifermann, Stefan Heißler, Maike Schliephake, Franziska Dopp, Claudia Muhle‐Goll, Pavel A. Levkin   +7 more
wiley   +1 more source

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source

Inclusion interaction of cyclodextrins and 2,4-dichlorprop methyl ester enantiomers by UV spectra

浙江大学学报. 农业与生命科学版, 2008
The enantioselective inclusion interaction of various cyclodextrins (β-CD, PM-β-CD, CM-β-CD) with R/S-2, 4-dichlorprop methyl ester (R/S-2, 4-D) was studied by UV spectra technique.
LI Hong, LIU Hui-jun, WEN Yue-zhong, LIU Wei-ping   +3 more
doaj   +1 more source

Cyclodextrin Inclusion Complexes for Improved Drug Bioavailability and Activity: Synthetic and Analytical Aspects

Pharmaceutics, 2023
Many active pharmaceutical ingredients show low oral bioavailability due to factors such as poor solubility and physical and chemical instability.
Álvaro Sarabia-Vallejo, María del Mar Caja, Ana I. Olives, M. Antonia Martín, J. Carlos Menéndez   +4 more
doaj   +1 more source

Cyclodextrin‐Functionalized Light‐Driven Cu2O Micromotors for Simultaneous Capture and Degradation of Bisphenol A

Advanced Robotics Research, EarlyView.
Fuel‐free Cu2O‐based micromotors functionalized with β‐cyclodextrin actively remove bisphenol A from water under visible light. The cyclodextrin shell captures BPA and enhances micromotor motility, leading to faster degradation and higher overall removal than nonfunctionalized Cu2O and Cu2O@Au.
Luisa Natalia Cordoba Urresti, Rebeca Ferrer Campos, Yufen Chen, Katherine Villa   +3 more
wiley   +1 more source

Cyclodextrins: Only Pharmaceutical Excipients or Full-Fledged Drug Candidates?

Pharmaceutics, 2022
Cyclodextrins, representing a versatile family of cyclic oligosaccharides, have extensive pharmaceutical applications due to their unique truncated cone-shaped structure with a hydrophilic outer surface and a hydrophobic cavity, which enables them to ...
Tamas Kovacs, Peter Nagy, Gyorgy Panyi, Lajos Szente, Zoltan Varga, Florina Zakany   +5 more
doaj   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Calixarene-based amphiphiles : synthesis, self-assembly and interaction with DNA [PDF]

, 2015
The present doctoral thesis focused on the synthesis of amphiphilic calix[4]arenes, the study of their self-assembly properties at the air-water interface as Langmuir monolayers or in solution as nanoparticles and on the DNA-binding properties of the ...
Rullaud, Vanessa
core   +1 more source

Artificial Host‐Guest Recognition Directs Glycometabolically Engineered Macrophages to Tumors

Advanced Science, EarlyView.
Glycoengineered supramolecular macrophages (GSAR‐M) are developed using glycometabolic labeling for bioorthogonal host‐guest tumor targeting. This engineering approach unexpectedly enhances macrophage migration, phagocytosis, and pseudopodia formation. Consequently, GSAR‐M demonstrate robust tumor‐targeting specificity, effectively arrest tumor growth,
Zhiqing Yang, Qian Cheng, Ziyi Wang, Jianwen Wei, Qun Guan, Huazhong Yu, Qingwen Zhang, Caixia Yin, Ruibing Wang   +8 more
wiley   +1 more source