Development of antibody‐drug conjugates in cancer: Overview and prospects
Cancer Communications, Volume 44, Issue 1, Page 3-22, January 2024.Abstract In recent years, remarkable breakthroughs have been reported on antibody‐drug conjugates (ADCs), with 15 ADCs successfully entering the market over the past decade. This substantial development has positioned ADCs as one of the fastest‐growing domains in the realm of anticancer drugs, demonstrating their efficacy in treating a wide array of ...
Dan‐Yun Ruan +3 more
wiley +1 more source
Non-Natural Linker Configuration in 2,6-Dipeptidyl-Anthraquinones Enhances the Inhibition of TAR RNA Binding/Annealing Activities by HIV-1 NC and Tat Proteins [PDF]
, 2018 The HIV-1 nucleocapsid (NC) protein represents an excellent molecular target for the development of antiretrovirals by virtue of its well-characterized chaperone activities, which play pivotal roles in essential steps of the viral life cycle. Our ongoing
Caliendo, Giuseppe +16 more
core +2 more sources
Intrauterine Exposure to Phthalates and Child Growth in the First Year of Life: Results from the BiTwin Cohort [PDF]
Phthalates are among the endocrine-disrupting compounds with higher widespread in daily life. Our objective was to assess the associations between maternal exposure to phthalates assessed by urinary phthalate metabolites and growth at birth and in the ...
Barros, H +5 more
core +2 more sources
Synthesis of Isomeric Hexahydro- and Perhydroisoindol-1-ones [PDF]
, 1978 Catalytic hydrogenation of triethyl 2-cyanocyclohex-1-(XIV) and -2(XV)-ene-1,5,5-tricarboxylates yielded the corresponding 2- -cyanocyclohexane (XVII) and diethyl perhydroisoindol-1-one-6,6- -dicarboxylate (V), the latter being formed through ...
D. Frgačić +2 more
core +1 more source
Research on Taste and Aroma Characteristics of Dahongpao Tea with Different Grades
ChemosensorsThis study aimed to thoroughly investigate the quality differences and influencing factors of Dahongpao tea of different grades. Through sensory evaluation, electronic nose analysis, electronic tongue analysis, biochemical component analysis, and HS-SPME-
Xiaomin Pang +9 more
doaj +1 more source
Second-generation sulfonamide inhibitors of D-glutamic acid-adding enzyme: activity optimisation with conformationally rigid analogues of D-glutamic acid. [PDF]
, 2011 peer reviewedD-Glutamic acid-adding enzyme (MurD) catalyses the essential addition of d-glutamic acid to the cytoplasmic peptidoglycan precursor UDP-N-acetylmuramoyl-l-alanine, and as such it represents an important antibacterial drug-discovery target ...
Amoroso, Ana Maria +12 more
core +1 more source
Synthesis of ε-Caprolactam from Cyclohexanecarboxylic Acid by Using Liquid Sulfur Dioxide [PDF]
, 1965 Niichiro Tokura +2 more
openalex +1 more source
Journal of Pharmacological Sciences, 2013 We investigated in vivo efficacies of the newly synthesized VLA-4 antagonist Compound A {trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid} on Ascaris antigen ...
Gensuke Takayama +6 more
doaj
Development of gold-catalysed reactions and C-H functionalisations [PDF]
, 2018 This thesis is comprised of an introductory chapter, followed by four chapters outlining the research undertaken by the author throughout the duration of study. Chapter 1 provides an introduction to homogeneous gold(I) catalysis, focusing on the
Sutherland, Daniel
core
Excretion of benzoic acid derivatives in urine of sheep given intraruminal infusions of 3-phenylpropionic and cyclohexanecarboxylic acids [PDF]
, 1997 J. H. Pagella +4 more
openalex +1 more source