Development of antibody‐drug conjugates in cancer: Overview and prospects
Cancer Communications, Volume 44, Issue 1, Page 3-22, January 2024.Abstract In recent years, remarkable breakthroughs have been reported on antibody‐drug conjugates (ADCs), with 15 ADCs successfully entering the market over the past decade. This substantial development has positioned ADCs as one of the fastest‐growing domains in the realm of anticancer drugs, demonstrating their efficacy in treating a wide array of ...
Dan‐Yun Ruan +3 more
wiley +1 more source
Synthesis of Isomeric Hexahydro- and Perhydroisoindol-1-ones [PDF]
, 1978 Catalytic hydrogenation of triethyl 2-cyanocyclohex-1-(XIV) and -2(XV)-ene-1,5,5-tricarboxylates yielded the corresponding 2- -cyanocyclohexane (XVII) and diethyl perhydroisoindol-1-one-6,6- -dicarboxylate (V), the latter being formed through ...
D. Frgačić +2 more
core +1 more source
LC/ESI-MS analysis of underivatized amino acids and mass spectrum [PDF]
arXiv, 2016 We report the method of LC/ESI-MS analysis of underivatized amino acids with corresponding mass spectrum and fragmentation patterns. Diagnostic product ions determined by mass spectrometry can support the qualitative identification and quantitative estimation of individual amino acids. Therefore, the optimization of chromatographic separation using the
arxiv
Correlations of Amino Acids with Secondary Structure Types: Connection with Amino Acid Structure [PDF]
arXiv, 2005 The correlations of primary and secondary structures were analyzed using proteins with known structure from Protein Data Bank. The correlation values of amino acid type and the eight secondary structure types at distant position were calculated for distances between -25 and 25.
arxiv
Discovery of Quinic Acid Derivatives as Oral Anti-inflammatory Agents [PDF]
, 2010 Quinic acid (QA) esters found in hot water extracts of Uncaria tomentosa (a.k.a. Cat’s claw) exert anti-inflammatory activity through mechanisms involving inhibition of the pro-inflammatory transcription factor nuclear factor kappa B (NF-κB).
Zeng, Kui
core +1 more source
Biochemical and genetic insights into asukamycin biosynthesis [PDF]
, 2011 Asukamycin, a member of the manumycin family metabolites, is an antimicrobial and potential antitumor agent isolated from Streptomyces nodosus subsp. asukaensis.
Rui, Zhe
core +2 more sources
Linguistic mechanism of the evolution of amino acid frequencies and genomic GC content [PDF]
arXiv, 2006 Much information is stored in amino acid composition of protein and base composition of DNA. We simulated the evolution of amino acid frequencies and genomic GC content by a linguistic model. It is showed that the evolution of genetic code determines the evolution of amino acid frequencies and genomic GC content.
arxiv
Genetic Code Table: A note on the three splittings into amino acid classes [PDF]
arXiv, 2009 This note represents the further progress in understanding the determination of the genetic code by Golden mean (Rakocevic, 1998). Three classes of amino acids that follow from this determination (the 7 "golden" amino acids, 7 of their complements, and 6 non-complements) are observed now together with two further possible splittings into 4 x 5 and 5 x ...
arxiv
The human α2-plasmin inhibitor: functional characterization of the unique plasmin(ogen)-binding region [PDF]
, 2018 The human α2-plasmin inhibitor (A2PI) possesses unique N- and C-terminal extensions that significantly influence its biological activities. The C-terminal segment, A2PIC (Asn398-Lys452), contains six lysines thought to be involved in the binding to ...
Gerber, Simon +3 more
core
Characterisation and environmental effects of unresolved complex mixtures of hydrocarbons [PDF]
, 1995 Merged with duplicate record (10026.1/589) on 03.01.2017 by CS (TIS)This is a digitised version of a thesis that was deposited in the University Library.
Thomas, Kevin Victor
core +1 more source