Results 41 to 50 of about 24,541,782 (296)

Docking studies of some pyrazole containing compounds in the cyclooxygenase-2 active site [PDF]

Arhiv za farmaciju, 2023
Whereas nonselective nonsteroidal anti-inflammatory drugs, such as aspirin, ibuprofen and diclofenac, inhibit both cyclooxygenase-1 and cyclooxigenase-2 enzymes, selective inhibitors target cyclooxygenase-2, which is overexpressed in inflammation, but ...
Savić Jelena, Antonijević Marija, Crevar Milkica, Brborić Jasmina   +3 more
doaj  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Evidence That Links Loss of Cyclooxygenase-2 With Increased Asymmetric Dimethylarginine Novel Explanation of Cardiovascular Side Effects Associated With Anti-Inflammatory Drugs [PDF]

, 2014
Background—Cardiovascular side effects associated with cyclooxygenase-2 inhibitor drugs dominate clinical concern. Cyclooxygenase-2 is expressed in the renal medulla where inhibition causes fluid retention and increased blood pressure.
Warner, Timothy D., Mackenzie, L, Wang, Zhen, Armstrong, PCJ, Mitchell, JA, Kirkby, NS, Al’Yamani, Malak, Knowles, R, Al'Yamani, Malak, Armstrong, Paul C. J., Nuesing, RM, Knowles, Rebecca, Tomlinson, James A.P., Mitchell, Jane A., Mackenzie, Louise; id_orcid, Ahmetaj-Shala, Blerina, Wang, Z, Mackenzie, Louise, Al'Yamani, M, Ahmetaj-Shala, B, Mazi, S, Leiper, J, Nusing, Rolf M., Tomlinson, JAP, Tomlinson, James A. P., Mazi, Sarah, Mazi, Sara, Kirkby, Nicholas S., Armstrong, Paul C.J., Tucker, Arthur T., Warner, TD, Leiper, James, Tucker, AT   +32 more
core   +1 more source

Immunohistochemical expression of Cyclooxygenase-2 in colorectal carcinoma and its association with clinicopathological parameters

Zanco Journal of Medical Sciences, 2019
Background and objective: Inflammatory process and genetic factors play a key role in neoplasia of colorectal cancer. Cyclooxygenase-2 is involved in a variety of important cellular functions, including cell growth and differentiation, cancer cell ...
Payman MS. Salim, Saman S. Abdulla, Jalal A. Jalal   +2 more
doaj   +1 more source

Diagnostic Value of Cyclooxygenase-2 Serum Levels in Predicting Preterm Labor

Andalas Obstetrics and Gynecology Journal, 2020
Tujuan: Mengetahui nilai diagnostik kadar serum cyclooxygenase 2 dalam memprediksi persalinan preterm Metode:Pemeriksaan kadar COX-2 serum dengan metode ELISA pada Ibu hamil dengan kehamilan 28 minggu sampai 36 minggu dibandingkan dengan Ibu hamil ...
Wiwin Suhandri, Dovy Djanas
doaj   +1 more source

The Molecular Perspective: Cyclooxygenase-2 [PDF]

The Oncologist, 2000
Imagine preventing cancer before it even starts. Of course, cancer prevention starts at home. We can stay away from smoke, solvents, and sunlight, avoiding unnecessary risks to our cells. We can also eat healthy foods like fruits and vegetables that are filled with protective antioxidants and cleansing fiber.
openaire   +3 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production. [PDF]

, 2006
Inhibition of neuronal cyclooxygenase-2 (COX-2) and hence prostaglandin E2 (PGE2) synthesis by non-steroidal anti-inflammatory drugs has been suggested to protect neuronal cells in a variety of pathophysiological situations including Alzheimer's disease ...
Akundi, Ravi Shankar, Candelario-Jalil, Eduardo, Munoz, Eduardo, Eduardo Muñoz, Michael Hüll, Lieb, Klaus, Klaus Lieb, Akundi, Ravi S., Ravi S. Akundi, Fiebich, Bernd L., Kurt Appel, Bhatia, Harsharan S., Eduardo Candelario-Jalil, Harsharan S. Bhatia, Hull, Michael, Bernd L. Fiebich, Appel, Kurt   +16 more
core   +1 more source

ASPIRIN INHIBITION OF THROMBOXANE A(2) CYCLOOXYGENASE AND PROSTACYCLIN CYCLOOXYGENASE IN VIVO.

, 1987
ASPIRIN INHIBITION OF THROMBOXANE A(2) CYCLOOXYGENASE AND PROSTACYCLIN CYCLOOXYGENASE IN ...
ROSEMARY. ZARAGOZA (7952021)
core   +6 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source