Results 21 to 30 of about 24,541,782 (296)
Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E-2 production [PDF]
, 2004 Levels of prostaglandin E-2 (PGE(2)), a potent inhibitor of fibroblast function, are decreased in the lungs of patients with pulmonary fibrosis, which has been shown to be because of limited expression of cyclooxygenase-2 (COX-2).
McAnulty, R J +35 more
core +1 more source
Cyclooxygenase-2 in the Kidney [PDF]
Journal of the American Society of Nephrology, 2000 Prostaglandins are produced constitutively by many tissues in the body, including brain, gut, and kidney, and their synthesis increases at sites of inflammation. Cyclooxygenase (COX), the enzyme responsible for the initial rate-limiting metabolism of arachidonic acid to prostaglandin G2 ...
openaire +2 more sources
Selective COX-2 inhibitors and risk of myocardial infarction [PDF]
, 2005 Selective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids.
Sohn, Hae-Young +3 more
core +1 more source
Cyclooxygenase-2 in Cardiovascular Biology
Clinical Medicine Insights: Cardiology, 2008 Cyclooxygenase (COX), also known as prostaglandin endoperoxide synthase, is the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two COX isoforms have been identified, COX-1 and COX-2.
Joseph F. Murphy
doaj +1 more source
NF-κB "decoy" inhibits COX-2 expression in epileptic rat brain [PDF]
Journal of Integrative Neuroscience, 2020 There is a need to investigate the role of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression in the epileptic rat brain and cultured hippocampal neurons.
Jing Xu, Yiping Sun, Yongshun Zhao, Qifa Li, Biying Ge, Shufang Dai, Kemin Liu, Hong Xu, Lei Fu, Jie Zhao
doaj +1 more source
Cyclooxygenase-2 Immunoexpression in Invasive Breast Carcinoma: A Possible Prognostic Factor
Advanced Medical Journal, 2023 Background and objectives:cyclooxygenase-2 is well known to be overexpressed in breast cancer and it plays nega- tive effects on tumor growth and progression.
Maryam Abdulmajed Muhammad Ameen +2 more
doaj +1 more source
Cell Transplantation, 2019 Ovarian cancer is the leading cause of death among gynecological malignancies. Cyclooxygenase 2 is widely expressed in various cancer cells and participates in the occurrence and development of tumors by regulating a variety of downstream signaling ...
Xiao Zhang +6 more
doaj +1 more source
Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia [PDF]
, 2014 © The Author 2014. Published by Oxford University Press This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution,
Pedersen, TL +11 more
core +1 more source
Cyclooxygenase‐2 in gastrointestinal malignancies [PDF]
Cancer, 2019 Cyclooxygenase (COX) is an enzyme complex that plays an important role in the conversion of arachidonic acid to prostaglandins. Prostaglandins are essential modulators of signal transduction pathways, which contribute to the metastatic properties of gastrointestinal (GI) malignancies.
Ganji Purnachandra Nagaraju +1 more
openaire +2 more sources
Cyclooxygenase-2 and decidual immune cells
Reproductive and Developmental Medicine, 2019 Cyclooxygenase-2 (COX-2) is a rate-limiting enzyme in arachidonic acid (AA) metabolism. COX-2 and its products (prostanoids) serve versatile biological functions during pregnancy.
Si-Yao Ha +5 more
doaj +1 more source