Results 11 to 20 of about 107,900 (262)

Cyclooxygenase-2 [PDF]

OncoImmunology, 2013
Cyclooxygenase-2 and its product PGE2 play essential roles in inducing and maintaining the suppressive functions of MDSCs in cancer. Blockade of the COX-2/PGE2 pathway abolishes the induction of MDSCs in response to tumor-derived factors and thus may provide new opportunities for targeting MDSCs in cancer patients.
Yumeng Mao, Isabel Poschke, Rolf Kiessling   +2 more
openaire   +2 more sources

Influence of Inhibition of COX-2-Dependent Lipid Metabolism on Regulation of UVB-Induced Keratinocytes Apoptosis by Cannabinoids

Biomolecules, 2022
Inflammation and apoptosis are regulated by similar factors, including ultraviolet B (UVB) radiation and cannabinoids, which are metabolized by cyclooxygenase-2 (COX-2) into pro-apoptotic prostaglandin derivatives.
Piotr Wójcik, Michał Biernacki, Natalia Domian, Neven Žarković, Elżbieta Skrzydlewska   +4 more
doaj   +1 more source

Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats

Journal of Applied Oral Science, 2010
Prostaglandins control osteoblastic and osteoclastic function under physiological or pathological conditions and are important modulators of the bone healing process.
Ricardo Nogueira Fracon, Juliana Mazzonetto Teófilo, Izabela Cristina Moris, Teresa Lamano   +3 more
doaj   +1 more source

COX2 expression is associated with proliferation and tumor extension in vestibular schwannoma but is not influenced by acetylsalicylic acid intake

Acta Neuropathologica Communications, 2019
Acetylsalicylic acid has been linked to a lower risk for different cancer types, presumably through its inhibitory effect on cyclooxygenase 2.
Felix Behling, Vanessa Ries, Marco Skardelly, Irina Gepfner-Tuma, Martin Schuhmann, Florian-Heinrich Ebner, Ghazaleh Tabatabai, Antje Bornemann, Jens Schittenhelm, Marcos Tatagiba   +9 more
doaj   +1 more source

COX-2 “Cyclooxygenase 2“as a Prognostic marker in Breast Cancer

SVU - International Journal of Medical Sciences, 2021
Background: Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death among women in both developed and developing countries.
Fatma Zakaria Abdel-rahman , Amen H. Zaky, Ashraf Zedan, Tarek M. Elsaba, Adel Gabr   +4 more
doaj   +1 more source

NF-κB "decoy" inhibits COX-2 expression in epileptic rat brain [PDF]

Journal of Integrative Neuroscience, 2020
There is a need to investigate the role of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression in the epileptic rat brain and cultured hippocampal neurons.
Jing Xu, Yiping Sun, Yongshun Zhao, Qifa Li, Biying Ge, Shufang Dai, Kemin Liu, Hong Xu, Lei Fu, Jie Zhao
doaj   +1 more source

Cyclooxygenase-2 in the Kidney [PDF]

Journal of the American Society of Nephrology, 2000
Prostaglandins are produced constitutively by many tissues in the body, including brain, gut, and kidney, and their synthesis increases at sites of inflammation. Cyclooxygenase (COX), the enzyme responsible for the initial rate-limiting metabolism of arachidonic acid to prostaglandin G2 ...
openaire   +2 more sources

Antiinflamatórios não-hormonais: inibidores da ciclooxigenase 2 Nonsteroidal anti-inflammatory drugs: cyclooxygenase 2 inhibitors

Jornal de Pediatria, 2006
OBJETIVO: Analisar os antiinflamatórios não-hormonais (AINH) inibidores seletivos da Cox 2 quanto ao mecanismo de ação, principais indicações, posologia e efeitos adversos mais comuns.
Maria Odete Esteves Hilário, Maria Teresa Terreri, Cláudio Arnaldo Len   +2 more
doaj   +1 more source

Cyclooxygenase-2 in Cardiovascular Biology

Clinical Medicine Insights: Cardiology, 2008
Cyclooxygenase (COX), also known as prostaglandin endoperoxide synthase, is the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two COX isoforms have been identified, COX-1 and COX-2.
Joseph F. Murphy
doaj   +1 more source

Cyclooxygenase 2 Promotes Proliferation and Invasion in Ovarian Cancer Cells via the PGE2/NF-κB Pathway

Cell Transplantation, 2019
Ovarian cancer is the leading cause of death among gynecological malignancies. Cyclooxygenase 2 is widely expressed in various cancer cells and participates in the occurrence and development of tumors by regulating a variety of downstream signaling ...
Xiao Zhang, Keqin Yan, Lin Deng, Jing Liang, Haiyan Liang, Dingqing Feng, Bin Ling   +6 more
doaj   +1 more source