Results 31 to 40 of about 107,900 (262)
Molecules, 2021 Pterocephalus hookeri, as a kind of popular traditional Tibetan medicine, is reputed to treat inflammatory related diseases. In the present work, a cyclooxygenase-2 functionalized affinity solid-phase extraction HPLC system was developed and combined ...
Yunhe Zhu +8 more
doaj +1 more source
Cyclooxygenase‐2 in gastrointestinal malignancies [PDF]
Cancer, 2019 Cyclooxygenase (COX) is an enzyme complex that plays an important role in the conversion of arachidonic acid to prostaglandins. Prostaglandins are essential modulators of signal transduction pathways, which contribute to the metastatic properties of gastrointestinal (GI) malignancies.
Ganji Purnachandra Nagaraju +1 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Survival after relapse in pediatric acute myeloid leukemia (AML) remains poor, highlighting the critical importance of identifying prognostic factors to guide optimal relapse management. Methods We investigated the prognostic impact of multiparameter flow cytometry (MFC) measurable residual disease (MRD) in 188 patients with first ...
Camilla Poulsen +21 more
wiley +1 more source
Zanco Journal of Medical Sciences, 2019 Background and objective: Inflammatory process and genetic factors play a key role in neoplasia of colorectal cancer. Cyclooxygenase-2 is involved in a variety of important cellular functions, including cell growth and differentiation, cancer cell ...
Payman MS. Salim +2 more
doaj +1 more source
Docking studies of some pyrazole containing compounds in the cyclooxygenase-2 active site [PDF]
Arhiv za farmaciju, 2023 Whereas nonselective nonsteroidal anti-inflammatory drugs, such as aspirin, ibuprofen and diclofenac, inhibit both cyclooxygenase-1 and cyclooxigenase-2 enzymes, selective inhibitors target cyclooxygenase-2, which is overexpressed in inflammation, but ...
Savić Jelena +3 more
doaj
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Despite 5‐year survival rates of over 90% among children and adolescents/young adults (CAYAs) with classic Hodgkin lymphoma (cHL), 15%–20% relapse after frontline therapy. Prior analysis of frontline Children's Oncology Group (COG) clinical trials demonstrated that, despite similar rates of relapse, non‐Hispanic Black (NHB) and ...
Mallorie B. Heneghan +14 more
wiley +1 more source
Diagnostic Value of Cyclooxygenase-2 Serum Levels in Predicting Preterm Labor
Andalas Obstetrics and Gynecology Journal, 2020 Tujuan: Mengetahui nilai diagnostik kadar serum cyclooxygenase 2 dalam memprediksi persalinan preterm Metode:Pemeriksaan kadar COX-2 serum dengan metode ELISA pada Ibu hamil dengan kehamilan 28 minggu sampai 36 minggu dibandingkan dengan Ibu hamil ...
Wiwin Suhandri, Dovy Djanas
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris +24 more
wiley +1 more source
Alternative polyadenylation of cyclooxygenase-2 [PDF]
Nucleic Acids Research, 2005 A biologically important human gene, cyclooxygenase-2 (COX-2), has been proposed to be regulated at many levels. While COX-1 is constitutively expressed in cells, COX-2 is inducible and is upregulated in response to many signals. Since increased transcriptional activity accounts for only part of the upregulation of COX-2, we chose to explore other RNA ...
Hall-Pogar, Tyra +3 more
openaire +2 more sources
Impact of Metastatic Patterns on Survival and Response to Therapy in Neuroblastoma
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background While the presence of metastases in neuroblastoma (NB) is a well‐established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
Mariona Morell‐Daniel +15 more
wiley +1 more source