Cyclooxygenase-2 inhibitors: promise or peril?
Mediators of Inflammation, 2002 The discovery of two isoforms of the cyclooxygenase enzyme, COX-1 and COX-2, and the development of COX-2-specific inhibitors as anti-inflammatories and analgesics have offered great promise that the therapeutic benefits of NSAIDs could be optimized ...
Laurel J. Mengle-Gaw +1 more
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Efficacy and safety of cyclooxygenase 2 inhibitors for desmoid tumor management: a systematic review. [PDF]
Nagoya J Med Sci, 2021 The efficacy and safety of cyclooxygenase 2 (COX2) inhibitors for the treatment of desmoid-type fibromatosis (DF) are unclear. Therefore, we systematically reviewed related literature to assess the efficacy and safety of COX2 inhibitors for DF treatment.
Emori M +4 more
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Frontiers in Psychiatry, 2019 Neuropsychiatric disorders, such as depression, bipolar disorder, schizophrenia, obsessive-compulsive disorder, and neurodevelopmental disorders such as autism spectrum disorder, are associated with significant illness burden.
Rickinder Sethi +14 more
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Editorial: Risk of cardiovascular events and cyclooxygenase-2 inhibitors ||FREE PAPER||
Vascular Health and Risk Management, 2006 Reza TabrizchiDivision of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John’s, NL, CanadaSelective cyclooxygenase-2 (Cox-2) inhibitors have been at the centre of public attention since the revelation that the
Reza Tabrizchi
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Role of Selective Cyclooxygenase-2 Inhibitors in Renal Colic Pain Reduction and Improvement: A Systematic Review of Clinical Trials [PDF]
, 2023 Renal colic is an irritating condition that develops after obstruction of the ureter. Selective cyclooxygenase-2 inhibitors are types of non-steroidal anti-inflammatory drugs (NSAIDs) that have beneficial role in treatment various diseases.
Mohammadian Amiri, Mehdi +6 more
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Selective COX-2 inhibitors and risk of myocardial infarction [PDF]
, 2005 Selective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids.
Sohn, Hae-Young +3 more
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Microwave-assisted synthesis of a series of 4,5-dihydro-1H-pyrazoles endowed with selective COX-1 inhibitory potency [PDF]
Journal of the Serbian Chemical Society, 2023 Considerable efforts have been directed towards the discovery of selective cyclooxygenase isoxyme 1 (COX-1) inhibitors due to the recent work highlighting the involvement of COX-1 in the pathogenesis of pain, neuroinflammation, cancer and cardiovascular ...
Altintop Mehlika Dilek +2 more
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Computational bioprospecting of andrographolide derivatives as potent cyclooxygenase-2 inhibitors
Biomedical and Biotechnology Research Journal, 2021 Background: Inflammation is a protective response of the human body that still causes a high level of discomfort because of the associated pain and other inflammatory reactions. Nonsteroidal anti-inflammatory drugs (NSAIDs) have certain associated severe
Somdutt Mujwar
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Jornal de Pediatria, 2006 OBJETIVO: Analisar os antiinflamatórios não-hormonais (AINH) inibidores seletivos da Cox 2 quanto ao mecanismo de ação, principais indicações, posologia e efeitos adversos mais comuns.
Maria Odete Esteves Hilário +2 more
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Novel biphasic role of lipoxinA4 on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts [PDF]
, 2011 Fibroblasts are important to host defence and immunity, can also as initiators of inflammation as well. As the endogenous "braking signal", Lipoxins can regulate anti-inflammation and the resolution of inflammation.
Gao, F. +24 more
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