Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years [PDF]
Acta Pharmaceutica Sinica B, 2022 Cyclooxygenases play a vital role in inflammation and are responsible for the production of prostaglandins. Two cyclooxygenases are described, the constitutive cyclooxygenase-1 and the inducible cyclooxygenase-2, for which the target inhibitors are the ...
Fen-Er Chen, Daniel Howell
exaly +3 more sources
Selective COX-2 Inhibitors: Road from Success to Controversy and the Quest for Repurposing. [PDF]
Pharmaceuticals (Basel), 2022 The introduction of selective COX-2 inhibitors (so-called ‘coxibs’) has demonstrated tremendous commercial success due to their claimed lower potential of serious gastrointestinal adverse effects than traditional NSAIDs.
El-Malah AA +6 more
europepmc +2 more sources
Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors [PDF]
Saudi Pharmaceutical Journal, 2023 This review highlights the potential role of cyclooxygenase-2 enzyme (COX-2) in the pathogenesis of Alzheimer's disease (AD) and the potential therapeutic use of non-steroidal anti-inflammatory drugs (NSAIDs) in the management of AD. In addition to COX-2
Nathalie Moussa, Ninar Dayoub
doaj +2 more sources
Non-steroidal anti-inflammatory drugs: recent advances in the use of synthetic COX-2 inhibitors. [PDF]
RSC Med Chem, 2022 Cyclooxygenase (COX) enzymes comprise COX-1 and COX-2 isoforms and are responsible for prostaglandin production. Prostaglandins have critical roles in the inflammation pathway and must be controlled by administration of selective nonsteroidal anti ...
Ahmadi M +4 more
europepmc +2 more sources
Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management
Journal of Neuroinflammation, 2019 Epilepsy, a common multifactorial neurological disease, affects about 69 million people worldwide constituting nearly 1% of the world population.
Chitra Rawat +3 more
doaj +2 more sources
Risk of Nonunion with Nonselective NSAIDs, COX-2 Inhibitors, and Opioids. [PDF]
J Bone Joint Surg Am, 2020 BACKGROUND Cyclooxygenase-2 (COX-2) has been found to be important for fracture-healing in animal models, raising concerns about use of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors after fractures.
George MD +5 more
europepmc +2 more sources
COX-2 Inhibitors and Gastric Cancer
Gastroenterology Research and Practice, 2014 The evidence that cyclooxygenase-2 (COX-2) is upregulated and plays an important role in carcinogenesis of gastric cancer has triggered the topic of COX-2 inhibitors as chemopreventive agents for gastric cancer.
Zhen Wang, Jun-qiang Chen, Jin-lu Liu
doaj +2 more sources
Comparison of the efficacy and safety of selective COX-2 inhibitors and non-steroidal anti-inflammatory drugs in the treatment of COVID-19 patients: a systematic review and network meta-analysis [PDF]
BMC Infectious DiseasesBackground The global epidemic of novel coronaviruses remains severe, and COX-2 selective inhibitors have attracted attention due to their promising clinical potential.
Di Wu +4 more
doaj +2 more sources
Selective COX-2 Inhibitors as Neuroprotective Agents in Traumatic Brain Injury [PDF]
BiomedicinesTraumatic brain injury (TBI) is a significant contributor to mortality and morbidity in people, both young and old. There are currently no approved therapeutic interventions for TBI. Following TBI, cyclooxygenase (COX) enzymes generate prostaglandins and
Matthew I. Hiskens +2 more
doaj +2 more sources
Immunohistochemical Investigation of Cyclooxygenase-2 Expression in Rabbit Uterine Adenocarcinoma and the Potential Use of COX-2 Inhibitors in Cancer Therapy [PDF]
AnimalsCyclooxygenase-2 (COX-2) is overexpressed in many human and animal cancers. Selective COX-2 inhibitors have shown antitumoral effects in tumors with a high expression of COX-2.
Emanuela Vaccaro +9 more
doaj +2 more sources