Results 11 to 20 of about 26,709,678 (285)
Adverse Effects of COX-2 Inhibitors [PDF]
The Scientific World Journal, 2005 Cyclooxygenase-2 selective inhibitors (COXIBs) were developed with the prime object of minimizing gastrointestinal adverse effects, which are seen with the use of traditional nonsteroidal anti-inflammatory drugs (NSAIDs).
Jagdish N. Sharma, Najeeba M. Jawad
doaj +2 more sources
Antioxidants, 2016 Radiation therapy (RT) evolved to be a primary treatment modality for cancer patients. Unfortunately, the cure or relief of symptoms is still accompanied by radiation-induced side effects with severe acute and late pathophysiological consequences ...
M. Laube, T. Kniess, Jens Pietzsch
semanticscholar +2 more sources
Design and Evaluation of Synthesized Pyrrole Derivatives as Dual COX‑1 and COX‑2 Inhibitors Using FB-QSAR Approach [PDF]
ACS Omega, 2023 Shoruq Ahmed Naji +5 more
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SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING OF DIARYLIMIDAZOLE DERIVATIVES AS NEW POTENTIAL ANTI-INFLAMMATORY AGENTS TARGETING COX-2 ENZYME [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2023 A series of diaryl imidazole derivatives (5a-h) was designed as novel selective COX-2 anti-inflammatory drug candidates. The designed compounds were synthesised, and their structures were characterized by spectroscopic analysis.
Amany Ghanim, Hend Abd El-wahab
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Journal of Internal Medicine, 2022 Nonsteroidal anti‐inflammatory drugs (NSAIDs) inhibit the enzyme cyclooxygenase (COX), which forms prostaglandins involved in pain and inflammation. COX inhibitors have analgesic and anti‐inflammatory effects, but also increase risks for gastrointestinal
C. Stiller, P. Hjemdahl
semanticscholar +1 more source
Cyclooxygenase-2-Prostaglandin E2 pathway: A key player in tumor-associated immune cells
Frontiers in Oncology, 2023 Cyclooxygenases-2 (COX-2) and Prostaglandin E2 (PGE2), which are important in chronic inflammatory diseases, can increase tumor incidence and promote tumor growth and metastasis.
Kaipeng Jin +11 more
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COX-2 SPECIFIC INHIBITORS (COXIBS) CRISIS [PDF]
Basrah Journal of Surgery, 2003 Nonsteroidal anti-inflammatory drugs (NSAIDs) represent the most frequently prescribed medicine in the world. Their main disadvantages were related to their effect on the gut and kidney. Since the early 80s of the last century, drugs manufacturers try to
Abbas Ali Mansour
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Select dietary phytochemicals function as inhibitors of COX-1 but not COX-2. [PDF]
PLoS ONE, 2013 Recent clinical trials raised concerns regarding the cardiovascular toxicity of selective cyclooxygenase-2 (COX-2) inhibitors. Many active dietary factors are reported to suppress carcinogenesis by targeting COX-2. A major question was accordingly raised:
Haitao Li +8 more
doaj +1 more source
COX-2 as a potential biomarker and therapeutic target in melanoma
Cancer Biology & Medicine, 2020 With a constantly increasing incidence, cutaneous melanoma has raised the need for a better understanding of its complex microenvironment that may further guide therapeutic options. Melanoma is a model tumor in immuno-oncology. Inflammation represents an
Diana Valentina Tudor +7 more
doaj +1 more source
Role of Selective Cyclooxygenase-2 Inhibitors in Renal Colic Pain Reduction and Improvement: A Systematic Review of Clinical Trials [PDF]
, 2023 Renal colic is an irritating condition that develops after obstruction of the ureter. Selective cyclooxygenase-2 inhibitors are types of non-steroidal anti-inflammatory drugs (NSAIDs) that have beneficial role in treatment various diseases.
Mohammadian Amiri, Mehdi +6 more
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