Results 31 to 40 of about 26,709,678 (285)

Radiolabeled COX-2 Inhibitors for Non-Invasive Visualization of COX-2 Expression and Activity — A Critical Update

Molecules, 2013
Cyclooxygenase-2 (COX-2) is a key player in inflammation. Its overexpression is directly associated with various inflammatory diseases and, additionally, with several processes of carcinogenesis. The development of new selective COX-2 inhibitors (COXIBs)
Torsten Kniess, Markus Laube, Jens Pietzsch   +2 more
doaj   +1 more source

COX-1 and COX-2 participate in Bmv-induced PGE₂ release by preadipocytes.

, 2022
3T3-L1 preadipocytes were pretreated with COX-1 and COX-2 selective inhibitors SC-560 and NS-398, respectively, or vehicle (DMSO 2 present in supernatants was quantified by EIA. Results are expressed as mean + SEM (n = 4). #p p < 0.001 vs.
Carlos DeOcesano-Pereira (5459984), Rodrigo Maia-Marques (13215322), Danilo Santos Teixeira (13215325), Catarina Teixeira (549494), Priscila Motta Janovits (13215328), Elbio Leiguez (549488)   +5 more
core   +1 more source

COX-2 Inhibitors for Cancer Treatment in Dogs [PDF]

Pakistan Veterinary Journal, 2011
Cancer is one of the main causes of death in canines and felines, and this fact is probably related to the increase in the longevity of these species. The longer the animals live, the higher the exposure to carcinogenic agents will be.
Andrigo Barboza De Nardi*, Talita Mariana Morata Raposo1, Rafael Ricardo Huppes1, Carlos Roberto Daleck2 and Renée Laufer Amorim3
doaj  

Cyclooxygenase (COX)-2 modulates Toxoplasma gondii infection, immune response and lipid droplets formation in human trophoblast cells and villous explants

Scientific Reports, 2021
Congenital toxoplasmosis is represented by the transplacental passage of Toxoplasma gondii from the mother to the fetus. Our studies demonstrated that T. gondii developed mechanisms to evade of the host immune response, such as cyclooxygenase (COX)-2 and
Guilherme de Souza, Rafaela José Silva, Iliana Claudia Balga Milián, Alessandra Monteiro Rosini, Thádia Evelyn de Araújo, Samuel Cota Teixeira, Mário Cézar Oliveira, Priscila Silva Franco, Claudio Vieira da Silva, José Roberto Mineo, Neide Maria Silva, Eloisa Amália Vieira Ferro, Bellisa Freitas Barbosa   +12 more
doaj   +1 more source

The Effect of Selectivity of Inhibitors to Cox-2 Enzyme on Hepatobiliary and Platelet Function in Patients with Osteoarthritis

مجلة كلية الطب, 2010
Background: The development of non steroidal anti-inflammatory drugs (NSAIDs) was based principally on inhibiting cyclooxygenases (COX) activity. However, the identification of two COX- isoforms (i.e., COX-1 and COX-2) with different physiological ...
Ali M. Hadi, Falah H. AL-Malki, Shatha H. Ali   +2 more
doaj   +1 more source

Quantitative structure–activity relationship based modeling of substituted indole Schiff bases as inhibitor of COX-2

Journal of Saudi Chemical Society, 2016
We have performed the quantitative structure activity relationship (QSAR) study for N-1 and C-3 substituted indole shiff bases to understand the structural features that influence the inhibitory activity toward the cyclooxygenase-2 (COX-2) enzyme.
Amrita Dwivedi, Ajeet Singh, A.K. Srivastava   +2 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Rational design of biodegradable sulphonamide candidates treating septicaemia by synergistic dual inhibition of COX-2/PGE2 axis and DHPS enzyme

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
A new series of co-drugs was designed based on hybridising the dihydropteroate synthase (DHPS) inhibitor sulphonamide scaffold with the COX-2 inhibitor salicylamide pharmacophore through biodegradable linkage to achieve compounds with synergistic dual ...
Nada H. El-Dershaby, Soad A. El-Hawash, Shaymaa E. Kassab, Hoda G. Dabees, Ahmed E. Abdel Moneim, Ibrahim A. Abdel Wahab, Mohammad M. Abd-Alhaseeb, Mostafa M. M. El-Miligy   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source