Results 11 to 20 of about 108,744 (262)

Non-Steroidal Anti-Inflammatory Drugs in Alzheimer's Disease and Parkinson's Disease: Reconsidering the Role of Neuroinflammation

Pharmaceuticals, 2010
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases with age as the greatest risk factor. As the general population experiences extended life span, preparation for the prevention and treatment of these and
Amy H. Moore, Matthew J. Bigbee, Grace E. Boynton, Colin M. Wakeham, Hilary M. Rosenheim, Christopher J. Staral, James L. Morrissey, Amanda K. Hund   +7 more
doaj   +1 more source

Mechanisms of Bioactivities of Fucoidan from the Brown Seaweed Fucus vesiculosus L. of the Barents Sea

Marine Drugs, 2020
The aim of this study was to elucidate some mechanisms of radical scavenging and the anti-inflammatory, anti-hyperglycemic, and anti-coagulant bioactivities of high molecular weight fucoidan from Fucus vesiculosus in several in vitro models. Fucoidan has
Olga N. Pozharitskaya, Ekaterina D. Obluchinskaya, Alexander N. Shikov   +2 more
doaj   +1 more source

The cyclooxygenases.

Genome biology, 2004
Cyclooxygenases (COXs) catalyze the rate-limiting step in the production of prostaglandins, bioactive compounds involved in processes such as fever and sensitivity to pain, and are the target of aspirin-like drugs. COX genes have been cloned from coral, tunicates and vertebrates, and in all the phyla where they are found, there are two genes encoding ...
Chandrasekharan, NV, Simmons, Daniel L
openaire   +2 more sources

Cyclooxygenases and the cardiovascular system [PDF]

Pharmacology & Therapeutics, 2021
Cyclooxygenase (COX)-1 and COX-2 are centrally important enzymes within the cardiovascular system with a range of diverse, sometimes opposing, functions. Through the production of thromboxane, COX in platelets is a pro-thrombotic enzyme. By contrast, through the production of prostacyclin, COX in endothelial cells is antithrombotic and in the kidney ...
Mitchell, Jane A, Kirkby, Nicholas S, Ahmetaj-Shala, Blerina, Armstrong, Paul C, Crescente, Marilena, Ferreira, Plinio, Lopes Pires, Maria Elisa, Vaja, Ricky, Warner, Timothy D   +8 more
openaire   +4 more sources

Arachidonic acid and PGE2 regulation of hepatic lipogenic gene expression

Journal of Lipid Research, 1999
N–6 polyunsaturated fatty acids (PUFA) suppress hepatic and adipocyte de novo lipogenesis by inhibiting the transcription of genes encoding key lipogenic proteins.
Michelle K. Mater, Annette P. Thelen, Donald B. Jump   +2 more
doaj   +1 more source

Exogenous oxygen is required for prostanoid induction under brain ischemia as evidence for a novel regulatory mechanism

Journal of Lipid Research, 2023
Previously, we and others reported a rapid and dramatic increase in brain prostanoids (PG), including prostaglandins, prostacyclins, and thromboxanes, under ischemia that is traditionally explained through the activation of esterified arachidonic acid ...
Drew R. Seeger, Brennon Schofield, Derek Besch, Svetlana A. Golovko, Peddanna Kotha, Meredith Parmer, Shahram Solaymani-Mohammadi, Mikhail Y. Golovko   +7 more
doaj   +1 more source

Naturally occurring benzophenones and xanthones from Garcinia smeathmannii (Planch. & Triana) Oliv. displayed anti-inflammatory effects by modulating the activities of inflammatory mediators in LPS-stimulated RAW 264.7 macrophages

Frontiers in Pharmacology
Introduction: There is a growing interest in studying natural products for the identification of novel lead compounds for drug development for treating inflammatory diseases.
Mohammed Jeelani, Hugues Fouotsa, Osama A. Mohammed, Jaber Alfaifi, Salmon Adebayo, Mohammad Muzammil Ahmed, Amar Ibrahim Omer Yahia, Hanan Eissa, Emad Bahashwan, Nahid Ahmed Mohammed, Yousef Ayesh Alotaibi, Ashwaq Yahya Asiri, Assad Rezigallah, Muffarah Hamid Alharthi, Jean Paul Dzoyem, Adamu Imam Isa   +15 more
doaj   +1 more source

Chiral Derivatives of Xanthones: Investigation of the Effect of Enantioselectivity on Inhibition of Cyclooxygenases (COX-1 and COX-2) and Binding Interaction with Human Serum Albumin

Pharmaceuticals, 2017
Searching of new enantiomerically pure chiral derivatives of xanthones (CDXs) with potential pharmacological properties, particularly those with anti-inflammatory activity, has remained an area of interest of our group.
Carla Fernandes, Andreia Palmeira, Inês I. Ramos, Carlos Carneiro, Carlos Afonso, Maria Elizabeth Tiritan, Honorina Cidade, Paula C.A.G. Pinto, M. Lúcia M.F.S. Saraiva, Salette Reis, Madalena M.M. Pinto   +10 more
doaj   +1 more source

Interaction Study of 1, 3 Substituted Isatin Derivatives with Anti Inflammatory Properties with Cyclooxygenase 1 and 2 Enzymes by Molecular Docking Method

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2022
Introduction: Inflammation as the body's defense response is accompanied with various diseases. Prostaglandins are major mediators of inflammation produced by the cyclooxygenase enzymes.
Elham Jafari, Farshid Hassanzadeh, Nahal khayambashi, Valiollah Hajhashemi   +3 more
doaj  

The EPA oxylipin, 12-HEPE, directly regulates human platelet activity

Journal of Lipid Research
Arterial thrombosis, driven by platelet hyperactivity, is the underlying pathophysiology of most major cardiovascular events. Dietary fish oil supplementation containing ω-3 polyunsaturated fatty acids (PUFAs) elicits cardiovascular protection in at-risk
Krista Goerger, Livia Stanger, Andrew Rickenberg, Anthony Nguyễn, Taekyu Lee, Theodore R. Holman, Michael Holinstat   +6 more
doaj   +1 more source