Results 11 to 20 of about 113,056 (219)

Non-Steroidal Anti-Inflammatory Drugs in Alzheimer's Disease and Parkinson's Disease: Reconsidering the Role of Neuroinflammation

Pharmaceuticals, 2010
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases with age as the greatest risk factor. As the general population experiences extended life span, preparation for the prevention and treatment of these and
Amy H. Moore, Matthew J. Bigbee, Grace E. Boynton, Colin M. Wakeham, Hilary M. Rosenheim, Christopher J. Staral, James L. Morrissey, Amanda K. Hund   +7 more
doaj   +1 more source

Mechanisms of Bioactivities of Fucoidan from the Brown Seaweed Fucus vesiculosus L. of the Barents Sea

Marine Drugs, 2020
The aim of this study was to elucidate some mechanisms of radical scavenging and the anti-inflammatory, anti-hyperglycemic, and anti-coagulant bioactivities of high molecular weight fucoidan from Fucus vesiculosus in several in vitro models. Fucoidan has
Olga N. Pozharitskaya, Ekaterina D. Obluchinskaya, Alexander N. Shikov   +2 more
doaj   +1 more source

Arachidonic acid and PGE2 regulation of hepatic lipogenic gene expression

Journal of Lipid Research, 1999
N–6 polyunsaturated fatty acids (PUFA) suppress hepatic and adipocyte de novo lipogenesis by inhibiting the transcription of genes encoding key lipogenic proteins.
Michelle K. Mater, Annette P. Thelen, Donald B. Jump   +2 more
doaj   +1 more source

Exogenous oxygen is required for prostanoid induction under brain ischemia as evidence for a novel regulatory mechanism

Journal of Lipid Research, 2023
Previously, we and others reported a rapid and dramatic increase in brain prostanoids (PG), including prostaglandins, prostacyclins, and thromboxanes, under ischemia that is traditionally explained through the activation of esterified arachidonic acid ...
Drew R. Seeger, Brennon Schofield, Derek Besch, Svetlana A. Golovko, Peddanna Kotha, Meredith Parmer, Shahram Solaymani-Mohammadi, Mikhail Y. Golovko   +7 more
doaj   +1 more source

Naturally occurring benzophenones and xanthones from Garcinia smeathmannii (Planch. & Triana) Oliv. displayed anti-inflammatory effects by modulating the activities of inflammatory mediators in LPS-stimulated RAW 264.7 macrophages

Frontiers in Pharmacology
Introduction: There is a growing interest in studying natural products for the identification of novel lead compounds for drug development for treating inflammatory diseases.
Mohammed Jeelani, Hugues Fouotsa, Osama A. Mohammed, Jaber Alfaifi, Salmon Adebayo, Mohammad Muzammil Ahmed, Amar Ibrahim Omer Yahia, Hanan Eissa, Emad Bahashwan, Nahid Ahmed Mohammed, Yousef Ayesh Alotaibi, Ashwaq Yahya Asiri, Assad Rezigallah, Muffarah Hamid Alharthi, Jean Paul Dzoyem, Adamu Imam Isa   +15 more
doaj   +1 more source

Chiral Derivatives of Xanthones: Investigation of the Effect of Enantioselectivity on Inhibition of Cyclooxygenases (COX-1 and COX-2) and Binding Interaction with Human Serum Albumin

Pharmaceuticals, 2017
Searching of new enantiomerically pure chiral derivatives of xanthones (CDXs) with potential pharmacological properties, particularly those with anti-inflammatory activity, has remained an area of interest of our group.
Carla Fernandes, Andreia Palmeira, Inês I. Ramos, Carlos Carneiro, Carlos Afonso, Maria Elizabeth Tiritan, Honorina Cidade, Paula C.A.G. Pinto, M. Lúcia M.F.S. Saraiva, Salette Reis, Madalena M.M. Pinto   +10 more
doaj   +1 more source

Interaction Study of 1, 3 Substituted Isatin Derivatives with Anti Inflammatory Properties with Cyclooxygenase 1 and 2 Enzymes by Molecular Docking Method

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2022
Introduction: Inflammation as the body's defense response is accompanied with various diseases. Prostaglandins are major mediators of inflammation produced by the cyclooxygenase enzymes.
Elham Jafari, Farshid Hassanzadeh, Nahal khayambashi, Valiollah Hajhashemi   +3 more
doaj  

The EPA oxylipin, 12-HEPE, directly regulates human platelet activity

Journal of Lipid Research
Arterial thrombosis, driven by platelet hyperactivity, is the underlying pathophysiology of most major cardiovascular events. Dietary fish oil supplementation containing ω-3 polyunsaturated fatty acids (PUFAs) elicits cardiovascular protection in at-risk
Krista Goerger, Livia Stanger, Andrew Rickenberg, Anthony Nguyễn, Taekyu Lee, Theodore R. Holman, Michael Holinstat   +6 more
doaj   +1 more source

In-Silico Evaluation of Binding Interaction and ADME Properties of Novel Pyrazoline and Pyrimidine Derivatives Targeting Cyclooxygenase-2 Enzyme

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Inflammation is a crucial defense mechanism against toxic stimuli and physical traumas. This study aimed to design six new pyrazoline and pyrimidine derivatives and assess their potential anti-inflammatory activity by targeting the cyclooxygenase (COX ...
Sarmad Abbas Fadhil, Karima Fadhil Ali, Wesen Adel Mehde   +2 more
doaj   +1 more source

Methyl Salicylate Lactoside Protects Neurons Ameliorating Cognitive Disorder Through Inhibiting Amyloid Beta-Induced Neuroinflammatory Response in Alzheimer’s Disease

Frontiers in Aging Neuroscience, 2018
Neuroinflammatory reactions mediated by microglia and astrocytes have been shown to play a key role in early progression of Alzheimer’s disease (AD). Increased evidences have demonstrated that neurons exacerbate local inflammatory reactions by producing ...
Jinze Li, Xiaowei Ma, Xiaowei Ma, Yu Wang, Chengjuan Chen, Min Hu, Linlin Wang, Junmin Fu, Gaona Shi, Dongming Zhang, Tiantai Zhang   +10 more
doaj   +1 more source