Results 21 to 30 of about 109,753 (261)

In-Silico Evaluation of Binding Interaction and ADME Properties of Novel Pyrazoline and Pyrimidine Derivatives Targeting Cyclooxygenase-2 Enzyme

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Inflammation is a crucial defense mechanism against toxic stimuli and physical traumas. This study aimed to design six new pyrazoline and pyrimidine derivatives and assess their potential anti-inflammatory activity by targeting the cyclooxygenase (COX ...
Sarmad Abbas Fadhil, Karima Fadhil Ali, Wesen Adel Mehde   +2 more
doaj   +1 more source

Methyl Salicylate Lactoside Protects Neurons Ameliorating Cognitive Disorder Through Inhibiting Amyloid Beta-Induced Neuroinflammatory Response in Alzheimer’s Disease

Frontiers in Aging Neuroscience, 2018
Neuroinflammatory reactions mediated by microglia and astrocytes have been shown to play a key role in early progression of Alzheimer’s disease (AD). Increased evidences have demonstrated that neurons exacerbate local inflammatory reactions by producing ...
Jinze Li, Xiaowei Ma, Xiaowei Ma, Yu Wang, Chengjuan Chen, Min Hu, Linlin Wang, Junmin Fu, Gaona Shi, Dongming Zhang, Tiantai Zhang   +10 more
doaj   +1 more source

Arg-Vasotocin Directly Activates Isotocin Receptors and Induces COX2 Expression in Ovoviviparous Guppies

Frontiers in Endocrinology, 2021
Oxytocin (OT) is a crucial regulator of reproductive behaviors, including parturition in mammals. Arg-vasopressin (AVP) is a nonapeptide homologous to Arg-vasotocin (AVT) in teleosts that has comparable affinity for the OT receptor. In the present study,
Li Kang Lyu, Jian Shuang Li, Xiao Jie Wang, Yi Jia Yao, Ji Fang Li, Yun Li, Hai Shen Wen, Xin Qi   +7 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Comparative Lipidomics of Caenorhabditis elegans Metabolic Disease Models by SWATH Non-Targeted Tandem Mass Spectrometry

Metabolites, 2015
Tandem mass spectrometry (MS/MS) with Sequential Window Acquisition of all Theoretical (SWATH) mass spectra generates a comprehensive archive of lipid species within an extract for retrospective, quantitative MS/MS analysis.
Jeevan K. Prasain, Landon Wilson, Hieu D. Hoang, Ray Moore, Michael A. Miller   +4 more
doaj   +1 more source

Different Chemical Structures and Physiological/Pathological Roles of Cyclooxygenases

Rambam Maimonides Medical Journal, 2021
This review describes cyclooxygenase (COX), which synthesizes prostanoids that play an important role in living things. The authors conducted a national and international literature review on the subject.
Yalcin Faki, Ayse Er
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

POTENSI KOMBINASI EKSTRAK AKAR SIDAGURI (Sida rhombifolia L.) DAN GETAH JARAK (Jatropha curcas L.) SEBAGAI BAHAN DEVITALISASI

ODONTO: Dental Journal, 2019
Background: Arsenic paste was used to devitalize dental pulp in some problems before surgical, but it has been proven to have many hazardous effects. So, other alternative drugs are needed that are equally effective but safer. Jatropha (Jatropha curcas L.
Maria Tanumihadja, Indrya Kirana Mattulada, Nurhayaty Natsir, Lukman Muslimin   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Bioactivity-Guided Isolation of Ethyl-<em>p</em>-methoxycinnamate, an Anti-inflammatory Constituent, from <em>Kaempferia galanga</em> L. Extracts

Molecules, 2012
This study evaluated the anti-inflammatory effect of <em>Kaempferia galanga </em>(KG) using an activity-guided approach. KG rhizomes were serially extracted with petroleum ether, chloroform, methanol and water.
Ashfaq Ahmed, Rabia Altaf, Mun Fei Yam, Item J. Atangwho, Mohd Zaini Asmawi, Amirin Sadikun, Muhammad Ihtisham Umar   +6 more
doaj   +1 more source