Results 191 to 200 of about 221,688 (338)

Immunohistochemical evaluation of cyclooxygenase-2 expression in feline nasal malignant epithelial tumours. [PDF]

J Feline Med Surg
Diop N, Canonne AM, Huet H, Reyes-Gomez E, Béguin J.   +4 more
europepmc   +1 more source

Limitation of myocardial infarct size in pigs with a dual lipoxygenase-cyclooxygenase blocking agent by inhibition of neutrophil activity without reduction of neutrophil migration

, 1993
Ezra A. Amsterdam, Hui‐Lin Pan, S. V. Rendig, J. David Symons, Mark P. Fletcher, John C. Longhurst   +5 more
openalex   +1 more source

Major Role for Cyclooxygenase (COX)-1 in the Control of Ductus Arteriosus(DA) Tone in Fetal Sheep • 116 [PDF]

, 1998
Pierre Hardy, Anne‐Marie Guerguerian, Mousumi Bhattacharya, Jean‐Claude Fouron, Ronald I. Clyman, Sylvain Chemtob   +5 more
openalex   +1 more source

Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs

Advanced Healthcare Materials, EarlyView.
This study demonstrates the safety of repeated application of three types of microarray patches (MAPs), hydrogelforming, dissolving, and implantable, over four weeks in miniature pigs. No adverse skin or systemic effects were observed, supporting the clinical potential of MAPs as safe and effective drug delivery platforms.
Qonita Kurnia Anjani, Aaron R. J. Hutton, Peter E. McKenna, Eneko Larrañeta, Ryan F. Donnelly   +4 more
wiley   +1 more source

Exploring the potential of <i>Laportea decumana</i> extract compounds as COX-1 and COX-2 inhibitors: An in silico study. [PDF]

Narra J
Simaremare ES, Kurniawan F, Hartati R, Tjahjono DH.   +3 more
europepmc   +1 more source

A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.

, 1990
Jason D. Morrow, Kristina E. Hill, Raymond F. Burk, Tarek Nammour, K F Badr, L. Jackson Roberts   +5 more
openalex   +1 more source

Suppressing t(4;11) Acute Leukemia by Lipopolymer Nanoparticle Delivery of siRNA Targeting KMT2A::AFF1 with Enhanced Extrahepatic Delivery

Advanced Healthcare Materials, EarlyView.
This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah, Remant KC, Amarnath Praphakar Rajendran, Saba Abbasi Dezfouli, Cezary Kucharski, Xiaoyan Jiang, Spencer B. Gibson, Joseph Brandwein, Olaf Heidenreich, Hasan Uludağ   +9 more
wiley   +1 more source

Cyclooxygenase-2 negatively regulates osteogenic differentiation in murine bone marrow mesenchymal stem cells via the FOXO3a/p27kip1 pathway. [PDF]

Bone Joint Res
Chuang SC, Chou YS, Lin YS, Chang JK, Chen CH, Ho ML.   +5 more
europepmc   +1 more source

The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.

, 1990
Jianmin Fu, Jaime L. Masferrer, Karen Seibert, A Raz, Philip Needleman   +4 more
openalex   +1 more source

Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy

Advanced Materials, EarlyView.
This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle, Dhruv Menon, João Conniot, Jon Ostolaza‐Paraiso, Sergio Mercado, Jhenifer Oliveira, Xu Chen, Bárbara B. Mendes, João Conde, David Fairen‐Jimenez   +9 more
wiley   +1 more source