Results 211 to 220 of about 108,744 (262)

Expression of Cyclooxygenase-1 and Cyclooxygenase-2 in the human prostate

Urology, 2000
To determine the cell-specific expression of the two major isoforms of cyclooxygenase (COX-1 and COX-2) in human noncancerous and cancerous prostatic tissues.Thirty-one specimens of prostate carcinoma (CaP) and 10 specimens of benign prostatic hyperplasia (BPH) were stained with mouse antihuman COX-1 and COX-2 monoclonal antibodies.
A, Kirschenbaum, A P, Klausner, R, Lee, P, Unger, S, Yao, X H, Liu, A C, Levine   +6 more
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Cyclooxygenase and Colon Cancer

Prostaglandins & Other Lipid Mediators, 2001
There is considerable interest in the involvement of cyclooxygenase-2 (COX-2) in colon carcinogenesis and its progression, because nonsteroidal anti-inflammatory drugs (NSAIDs) reduce mortality from colon cancer and COX-2 is one of the known targets of NSAIDs. COX-2 mRNA and protein levels are increased in colon cancer tissues from patients and in some
Naoki, Kawai, Masahiko, Tsujii, Shingo, Tsuji   +2 more
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Cloning and Expression of Cyclooxygenase-1 and Cyclooxygenase-2

2010
Cyclooxygenase (COX) enzymes play important roles in normal physiology and during inflammation of various cells and tissues. In order to help understand the functions of these enzymes, their genes can be cloned to facilitate the production of the proteins in recombinant form.
Nicholas R, Staten, Beverly A, Reitz
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Cyclooxygenase mechanisms

Current Opinion in Chemical Biology, 2000
Several advances have occurred in the past year in our understanding of cyclooxygenase catalysis. The role of specific heme oxidation states in the formation of catalytically competent tyrosyl radicals has been defined; the identity of physiological hydroperoxide activators has been established; and the participation of individual amino acids in ...
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Perspectives on the Cyclooxygenase-2/ Cyclooxygenase-1 Hypothesis

JCR: Journal of Clinical Rheumatology, 1998
The introduction of the cyclooxygenase (COX) hypothesis to explain both the therapeutic effects and the toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs) has provided direction for the development of preferential and highly selective COX-2 inhibitors, which retain efficacy against inflammation with reduced risk of toxicity. However, the complex
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Cyclooxygenase inhibition and thrombogenicity

The American Journal of Medicine, 2001
Cyclooxygenase (COX)-1 and COX-2 catalyze the formation of prothrombotic and antithrombotic eicosanoids, respectively. Aspirin, conventional nonsteroidal anti-inflammatory drugs (NSAIDs), and COX-2-specific inhibitors exhibit different patterns of inhibition of COX-1-mediated thromboxane biosynthesis and COX-2-mediated prostacyclin biosynthesis.
F, Catella-Lawson, L J, Crofford
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Cyclooxygenase-2 and carcinogenesis

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2000
Numerous investigations have shown that COX-2 is a participant in the pathway of colon carcinogenesis, especially when mutation of the APC tumor suppressor is the initiating event. Moreover, it seems that the amount of COX-2 is important, since there is a correlation between its level of expression and the size of the tumors and their propensity to ...
S M, Prescott, F A, Fitzpatrick
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Prostaglandin cyclooxygenase

Progress in Lipid Research, 1981
F A, Kuehl, R W, Egan, J L, Humes
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[Cyclooxygenases].

Presse medicale (Paris, France : 1983), 2001
TWO ISOFORMS: There are two isoforms of cyclooxygenase (COX) with similar structure and metabolic activity. COX-1 is a constitutional enzyme. COX-2 is an inductible form. CYCLOOXYGENASE-1: COX-1 is present in most tissues, particularly in the kidney, the digestive tract mucosa, platelets, brain, liver and spleen.
P, Eschwège, V, de Ledinghen, T, Camilli, S, Kulkarni, G, Dalbagni, S, Droupy, A, Jardin, G, Benoît, B B, Weksler   +8 more
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The classification of cyclooxygenase inhibitors.

The Journal of rheumatology, 1998
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Lipsky, P.E., Abramson, S.B., Crofford, L.J., Dubois, R.N., Simon, L.S., Putte, L.B.A. van de   +5 more
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