Results 111 to 120 of about 23,800,079 (261)

Cyclooxygenase-2 and Ki67 Expression in Oral Leukoplakia: a Clinicopathological Study

eJournal of Oral Maxillofacial Research, 2015
Objectives: Oral leukoplakia is a precancerous lesion of the oral mucosa. The upregulation of Ki67 and cyclooxygenase-2 has been reported in both dysplastic and non-dysplastic tissues.
Alper Sinanoglu, Merva Soluk-Tekkesin, Vakur Olgac   +2 more
doaj   +1 more source

Synthesis and Preclinical Evaluation of ¹⁸F-Labeled Ketoprofen Methyl Esters for Cyclooxygenase-1 Imaging in Neuroinflammation. [PDF]

J Nucl Med, 2022
Shukuri M, Mawatari A, Takatani S, Tahara T, Inoue M, Arakaki W, Ohno M, Doi H, Onoe H.   +8 more
europepmc   +1 more source

Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: Implications for gastrointestinal toxicity [PDF]

, 1998
John L. Wallace, Adrian Bak, Webb McKnight, Samuel Asfaha, Keith A. Sharkey, Wallace K. MacNaughton   +5 more
openalex   +1 more source

Design and Synthesis of New Non-Steroidal Anti-inflammatory Agents with Expected Selectivity toward Cyclooxygenase-2

Iraqi Journal of Pharmaceutical Sciences, 2017
This study includes design and synthesis of new non-steroidal anti-inflammatory agents (NSAIDs) with expected cyclooxygenase-2 (COX-2) selective inhibition to achieve better activity and low gastric side effects.
Nadeem A. Abdul Razzak, Samera F.Hussan, Ahlam J. Qaseer   +2 more
doaj  

Investigating the Connection Between Endogenous Heme Accumulation and COX2 Activity in Cancer Cells

Frontiers in Oncology, 2019
Heme, an iron-containing porphyrin, is fundamental for a variety of functions in cell homeostasis. Nevertheless, recent data indicate that dysregulation of heme metabolism might promote tumorigenesis.
Francesca Destefanis, Veronica Fiorito, Fiorella Altruda, Emanuela Tolosano   +3 more
doaj   +1 more source

Whole-Body PET Imaging in Humans Shows That ¹¹C-PS13 Is Selective for Cyclooxygenase-1 and Can Measure the In Vivo Potency of Nonsteroidal Antiinflammatory Drugs. [PDF]

J Nucl Med, 2023
Kim MJ, Anaya FJ, Manly LS, Lee JH, Hong J, Shrestha S, Telu S, Henry K, Santamaria JAM, Liow JS, Zanotti-Fregonara P, Shetty HU, Zoghbi SS, Pike VW, Innis RB.   +14 more
europepmc   +1 more source

Interpreting the clinical significance of the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2 [PDF]

, 1999
Peter Brooks, Paul Emery, Jilly F. Evans, Helmut Fenner, C J Hawkey, Carlo Patrono, Josef S Smolen, F. C. Breedveld, Richard O. Day, Maxime Dougados, Elliot Ehrich, J Gijón-Baños, Tore K. Kvien, M. H. van Rijswijk, Timothy D. Warner, H. Zeidler   +15 more
openalex   +1 more source

Synthesis of [¹⁸F]PS13 and Evaluation as a PET Radioligand for Cyclooxygenase-1 in Monkey. [PDF]

ACS Chem Neurosci, 2021
Taddei C, Morse CL, Kim MJ, Liow JS, Montero Santamaria J, Zhang A, Manly LS, Zanotti-Fregonara P, Gladding RL, Zoghbi SS, Innis RB, Pike VW.   +11 more
europepmc   +1 more source

Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase-1. [PDF]

, 1997
S M Cohn, Suzanne Schloemann, Teresa G. Tessner, Karen Seibert, William F. Stenson   +4 more
openalex   +1 more source

Both cyclooxygenase-1 and cyclooxygenase-2 mediate osteoblast response to titanium surface roughness

Journal of Biomedical Materials Research, 2001
Previous studies suggest that the enhanced expression of the osteoblastic phenotype exhibited by MG63 osteoblast-like cells on rough Ti surfaces (R(a) 4-5 microm) involves increased production of prostaglandin. Inhibition of prostaglandin synthesis by indomethacin blocks surface-roughness-dependent decreases in cell proliferation and increases in ...
M. Sisk, Y. Liu, David L. Cochran, B. D. Boyan, B. D. Boyan, Victor L. Sylvia, David D Dean, Zvi Schwartz, C. H. Lohmann   +8 more
openaire   +4 more sources