Microwave-assisted synthesis of a series of 4,5-dihydro-1H-pyrazoles endowed with selective COX-1 inhibitory potency [PDF]
Journal of the Serbian Chemical Society, 2023 Considerable efforts have been directed towards the discovery of selective cyclooxygenase isoxyme 1 (COX-1) inhibitors due to the recent work highlighting the involvement of COX-1 in the pathogenesis of pain, neuroinflammation, cancer and cardiovascular ...
Altintop Mehlika Dilek +2 more
doaj +1 more source
BMC Endocrine Disorders, 2020 Background Pituitary adenomas as multifactorial intracranial neoplasms impose a massive burden of morbidity on patients and characterizing the molecular mechanism underlying their pathogenesis has received considerable attention.
Nasrin Akbari +9 more
doaj +1 more source
Expression and correlation of COX-2 and NUCB1 in colorectal adenocarcinoma [PDF]
PeerJ, 2023 Objective To investigate the expression and correlation of COX-2 and NUCB1 in colorectal adenocarcinoma and adjacent tissues. Methods The expression of COX-2 and NUCB1 and their effects on prognosis were predicted using bioinformatics ...
Yuanyuan Zhang +5 more
doaj +2 more sources
Three-dimensional structure of human cyclooxygenase (hCOX)-1
Scientific Reports, 2021 The beneficial effects of Cyclooxygenases (COX) inhibitors on human health have been known for thousands of years. Nevertheless, COXs, particularly COX-1, have been linked to a plethora of human diseases such as cancer, heart failure, neurological and ...
Morena Miciaccia +9 more
doaj +1 more source
Ancient Science of Life, 2018 Background: Agnimantha is a constituent of the bṛhatpañcamūla (the roots drugs of 5 tree species) which in turn is a part of daśamūla used in Ayurvedic pharmaceutical practices.
Narasimha Baba Brindavanam +3 more
doaj +1 more source
Interaction of meloxicam and phenylbutazone on the level of cyclooxygenase-2 in mice [PDF]
Iraqi Journal of Veterinary Sciences, 2022 The reason for the recent study was to inspect the therapeutic efficacy of meloxicam and phenylbutazone alone with their analgesic interaction and their subsequent inhibitory interaction at the level of cyclooxygenase-2 in mice.
Yaareb J. Mousa +2 more
doaj +1 more source
Conformational effects on the pro-S hydrogen abstraction reaction in cyclooxygenase-1: an integrated QM/MM and MD study [PDF]
, 2013 A key step in the cyclooxygenase reaction cycle of cyclooxygenase 1 (COX-1) is abstraction of the pro-S hydrogen atom of the arachidonic acid by a radical that is formed at the protein residue Tyr-385.
Adrian J. Mulholland +20 more
core +1 more source
Differential expression of cyclooxygenase 1 and cyclooxygenase 2 in the bovine oviduct [PDF]
Journal of Endocrinology, 2006 The aim of the present study was to investigate the enzymes for the local prostaglandin (PG) biosynthesis present in the bovine oviduct during the estrous cycle to influence early reproductive events. Bovine oviducts were classified into four phases: pre-ovulatory, post-ovulatory, early-to-mid luteal, and late luteal phase, subdivided further into ipsi-
Simone Odau +3 more
openaire +2 more sources
Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity. [PDF]
, 2007 he important role of cyclooxygenase-2 (COX-2) in the pathogenesis of inflammation and side effect limitations of current COX-2 inhibitor drugs illustrates a need for the design of new compounds based on alternative structural templates.
ANZELLOTTI P +17 more
core +1 more source
Role of shear stress in endothelial cell morphology and expression of cyclooxygenase isoforms [PDF]
, 2011 MEDLINE® is the source for the MeSH terms of this document.Objective-: The goal of this study was to examine the effect of chronic heterogeneous shear stress, applied using an orbital shaker, on endothelial cell morphology and the expression of ...
Berson, R.E. +9 more
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