Cyclooxygenase-1 (COX-1) and COX-1 Inhibitors in Cancer: A Review of Oncology and Medicinal Chemistry Literature [PDF]
Pharmaceuticals, 2018 Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2.
Mauro Coluccia, Alessandra Pannunzio
exaly +4 more sources
Spatiotemporally distinct roles of cyclooxygenase-1 and cyclooxygenase-2 at fetomaternal interface in mice [PDF]
JCI InsightEmbryo implantation is crucial for ensuring a successful pregnancy outcome and subsequent child health. The intrauterine environment during the peri-implantation period shows drastic changes in gene expression and cellular metabolism in response to ...
Shizu Aikawa +20 more
doaj +4 more sources
Is cyclooxygenase-1 involved in neuroinflammation? [PDF]
J Neurosci Res, 2021 Abstract Purpose: Reactive microglia are an important hallmark of neuroinflammation. Reactive microglia release various inflammatory mediators, such as cytokines, chemokines, and prostaglandins, which are produced by enzymes like cyclooxygenases (COX).
Ghazanfari N +4 more
europepmc +4 more sources
The role of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide and interleukin-1 stimulated enterocyte prostanoid formation [PDF]
Mediators of Inflammation, 1998 Lipopolysaccharide is an inflammatory agent and interleukin-1 is a cytokine. Their pro-inflammatory effects may be mediated by prostanoids produced by inducible cyclooxygenase-2.
W. E. Longo +5 more
doaj +3 more sources
Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues [PDF]
FEBS Letters, 1993 The rate‐limiting step in the formation of prostanoids is the conversion of arachidonic acid to prostaglandin H2 by cyclooxygenase, also known as prostaglandin G/H synthase/cyclooxygenase. Two forms of cyclooxygenase have been characterized: a ubiquitously expressed form (COX‐1) and a recently described second form (COX‐2) inducible by various factors ...
A W Ford-Hutchinson, G P O'Neill
exaly +3 more sources
Expression of cyclooxygenase-1 and cyclooxygenase-2 in normal and pathological human oral mucosa.
Folia Histochemica et Cytobiologica, 2011 Cyclooxigenase (COX) is the rate-limiting enzyme for the conversion of arachidonic acid (AA) to prostaglandins (PGs). Two isoforms of COX have been identified: COX-1 is constitutively expressed in many cells and is involved in cell homeostasis ...
Francesco Burruano +7 more
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Platelet inhibition by low-dose aspirin is not influenced by body mass or weight
Platelets, 2022 Aspirin’s clinical efficacy may be influenced by body weight and mass. Although inadequate platelet inhibition by aspirin is suggested as responsible, evidence for this in non-diabetic patients is sparse.
Sean P. Heffron +4 more
doaj +1 more source
Microwave-assisted synthesis of a series of 4,5-dihydro-1H-pyrazoles endowed with selective COX-1 inhibitory potency [PDF]
Journal of the Serbian Chemical Society, 2023 Considerable efforts have been directed towards the discovery of selective cyclooxygenase isoxyme 1 (COX-1) inhibitors due to the recent work highlighting the involvement of COX-1 in the pathogenesis of pain, neuroinflammation, cancer and cardiovascular ...
Altintop Mehlika Dilek +2 more
doaj +1 more source
BMC Endocrine Disorders, 2020 Background Pituitary adenomas as multifactorial intracranial neoplasms impose a massive burden of morbidity on patients and characterizing the molecular mechanism underlying their pathogenesis has received considerable attention.
Nasrin Akbari +9 more
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Three-dimensional structure of human cyclooxygenase (hCOX)-1
Scientific Reports, 2021 The beneficial effects of Cyclooxygenases (COX) inhibitors on human health have been known for thousands of years. Nevertheless, COXs, particularly COX-1, have been linked to a plethora of human diseases such as cancer, heart failure, neurological and ...
Morena Miciaccia +9 more
doaj +1 more source