Results 21 to 30 of about 106,475 (259)
Neurobiology of Disease, 2007 Epidemiological and experimental data implicate maternal–fetal infection and an associated increase in circulating cytokines in the etiology of cerebral palsy.
Géraldine Favrais +3 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 The work reported herein describes the synthesis of a new series of anti-inflammatory pyrazolyl thiazolones. In addition to COX-2/15-LOX inhibition, these hybrids exerted their anti-inflammatory actions through novel mechanisms. The most active compounds
Perihan A. Elzahhar +7 more
doaj +1 more source
Chemistry Central Journal, 2012 Background Thromboxane A2 is derived from arachidonic acid through the action of cyclooxygenases and thromboxane synthase. It is mainly formed in blood platelets upon activation and plays an important role in aggregation. Aspirin is effective in reducing
Hirz Taghreed +10 more
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RAW264.7 cells lack prostaglandin-dependent autoregulation of tumor necrosis factor-α secretion
Journal of Lipid Research, 2005 Studies of the response of RAW264.7 cells (RAW) to lipopolysaccharide (LPS) were carried out to determine why these cells do not demonstrate the prostaglandin (PG)-dependent autocrine regulation of tumor necrosis factor-α (TNF-α) secretion observed in ...
Carol A. Rouzer +5 more
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Involvement of peripheral cyclooxygenase-1 and cyclooxygenase-2 in inflammatory pain
Journal of Pharmacy and Pharmacology, 2002 Abstract Pain-induced functional impairment in the rat (PIFIR) is a model of inflammatory and arthritic pain similar to that of clinical gout. Nociception is induced by the intra-articular injection of uric acid into the right hind limb, inducing its dysfunction. Animals then receive analgesic drugs and the recovery of functionality over
Rosa Ventura, Martínez +5 more
openaire +2 more sources
Pharmacological analysis of cyclooxygenase-1 in inflammation [PDF]
Proceedings of the National Academy of Sciences, 1998 The enzymes cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandin (PG) H 2 , the precursor of PGs and thromboxane. These lipid mediators play important roles in inflammation and pain and in normal physiological functions.
C J, Smith +9 more
openaire +2 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Mediators of Inflammation, 2014 Cyclooxygenases and lipoxygenases are proinflammatory enzymes; the former affects platelet aggregation, vasoconstriction, vasodilatation and later the development of atherosclerosis.
Zsofia Kutil +7 more
doaj +1 more source
gem-Difluorobisarylic derivatives: design, synthesis and anti-inflammatory effect
BMC Chemistry, 2019 Introduction New fluorinated diaryl ethers and bisarylic ketones were designed and evaluated for their anti-inflammatory effects in primary macrophages.
Abeer J. Ayoub +11 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. The kinin B2 receptor agonist, bradykinin, has been implicated in AAA pathogenesis through promoting inflammation.
Corey S. Moran +5 more
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