Results 111 to 120 of about 207,862 (335)

Timing and Predictive Value of Clinical Conditions Preceding Multiple Sclerosis in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Multiple sclerosis (MS) patients often experience a higher incidence of clinical conditions before diagnosis, suggesting a prodromal phase. However, their predictive value and temporal trajectories remain underexplored. We investigated these aspects using the large UK Biobank's population‐based cohort, which provided clinical ...
Andrea Nova, Teresa Fazia, Giovanni Di Caprio, Davide Gentilini, Luisa Bernardinelli, Roberto Bergamaschi   +5 more
wiley   +1 more source

Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia [PDF]

, 2014
© The Author 2014. Published by Oxford University Press This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution,
Al-Mahdawi, Al-Mahdawi, Block, Campuzano, Campuzano, Capdevila, Capdevila, Castaldo, Chantrel-Groussard, Chen, Cossee, Dewitt, Durr, Durr, Feng, Genki Hayashi, Gino Cortopassi, Harding, John W. Newman, Kang, Koeppen, Li, Liang, Lin, Lu, Mark Pook, Masi, Michael, Miranda, Node, O'Flaherty, Paupe, Piemonte, Piro, Praticò, Qin, Ristow, Rojo, Samuelsson, Sanchez-Mejia, Schulz, Shan, Shi, Shin, Small, Smith, Strokin, Tan, Teismann, Theresa L. Pedersen, Tian, Wardlaw, Wong, Wong, Xi, Yan, Yan Shen, Zhang   +57 more
core   +2 more sources

Long‐Term Temporal Profile of Motor Recovery After Intracerebral Hemorrhage

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Limited data is available to describe the temporal profile of long‐term recovery over 1 year after the stroke in patients with spontaneous intracerebral hemorrhage (ICH). Methods A registered multicentral cohort was conducted to consecutively include non‐herniated supratentorial ICH patients from November 2013 to January 2023 ...
Yan Zheng, Fu‐Xin Lin, Ling‐Yun Zhuo, Jian‐Cai Chen, Xin Ge, Xiang‐Lin Chen, Xue‐Jiao Wang, Zhi‐Gang Yao, You‐Liang Tong, Bo Xie, Bai‐Hai Guo, Zhao‐Sheng Sun, Zhi‐Hua Tian, Ping Qiu, Xin‐Ru Lin, Qiu He, Shu‐Na Huang, Ke Ma, Fang‐Yu Wang, Huang‐Cheng Shang‐Guan, Wen‐Hua Fang, Deng‐Liang Wang, Ying Fu, Yuan‐Xiang Lin, De‐Zhi Kang   +24 more
wiley   +1 more source

Ku80 cooperates with CBP to promote COX-2 expression and tumor growth. [PDF]

, 2015
Cyclooxygenase-2 (COX-2) plays an important role in lung cancer development and progression. Using streptavidin-agarose pulldown and proteomics assay, we identified and validated Ku80, a dimer of Ku participating in the repair of broken DNA double ...
Chen, Yiming, Cheng, Wei, Dai, Meng, Deng, Wuguo, Du, Sha, Guo, Wei, Hu, Wenxian, Huang, Wenlin, Jia, Yunlu, Li, Mei, Li, Zhenglin, Liu, Quentin, Meng, Songshu, Qin, Yu, Wang, Jingshu, Wang, Shusen, Wu, Taihua, Xiao, Xiangsheng, Xiao, Yao, Xuan, Yang, Yi, Canhui, Yu, Wendan, Yuan, Yuhui, Zhao, Shilei   +23 more
core   +3 more sources

In Vitro Modeling of Natural Killer Cell Cytotoxicity to Inform Personalized ALS Therapeutics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Natural killer (NK) cells might contribute to motor neuron death in amyotrophic lateral sclerosis (ALS) through direct cytotoxicity, a process that could be inhibited with the FDA‐approved JAK/STAT pathway inhibitor, tofacitinib. This study aimed to verify that tofacitinib can suppress NK cell cytotoxicity, investigate if immune cell
Benjamin J. Murdock, Jihyun Park, Dae‐Gyu Jang, Bangyao Zhao, Samuel J. Teener, Ian F. Webber‐Davis, Lili Zhao, Eva L. Feldman, Stephen A. Goutman   +8 more
wiley   +1 more source

Human Intelectin-1 (hITL-1) as Modulator of Metabolic Syndrome (MetS): An In Silico Study

Journal of Pharmacy and Bioallied Sciences
Human intelectin-1 (hITL-1) has been known to be involved in diseases such as asthma, cancer, metabolic disorders, and inflammatory bowel disease. In the present study, we aimed to evaluate hITL-1 as modulator of metabolic syndrome (MetS) using an in ...
Vishnupriya N, Narayanaswamy Radhakrishnan   +1 more
doaj   +1 more source

Cyclo-Oxygenase 2 Modulates Chemoresistance in Breast Cancer Cells Involving NF-κB

Cellular Oncology, 2009
Background: Breast cancer cells can develop chemoresistance after prolonged exposure to cytotoxic drugs due to expression of the multi drug resistance (MDR) 1 gene.
Maria Chiara Zatelli, Daniela Molè, Federico Tagliati, Mariella Minoia, Maria Rosaria Ambrosio, Ettore Degli Uberti   +5 more
doaj   +1 more source

Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms [PDF]

, 2018
Platelet-activating factor (PAF) stimulates numerous cell types via activation of the G protein-coupled PAF receptor (PAFR). PAFR activation not only induces acute proinflammatory responses, but it also induces delayed systemic immunosuppressive effects ...
FitzGerald, Garret A., Kaplan, Mark H., Ocana, Jesus A., Pawelzik, Sven-Christian, Romer, Eric, Sahu, Ravi, Travers, Jeffrey B.   +6 more
core   +1 more source

High‐Efficacy Treatment in Neuromyelitis Optica Specturm Disorder Patients With Seropositive AQP4 Antibodies—A Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To compare the effectiveness of high‐efficacy treatments (HET) and low‐efficacy treatments (LET) in NMOSD patients with anti‐aquaporin‐4 antibodies (AQP4‐ab). Methods In this multi‐center study, we analyzed 183 AQP4‐ab seropositive NMOSD patients who received immunosuppressive treatments (IST).
Xiang Li, Binbin Xue, Jia Li, Dewei Xie, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Xu Zhang, Junhui Xia, Jie Lin   +10 more
wiley   +1 more source

Immunohistochemical expression of Cyclooxygenase-2 in colorectal carcinoma and its association with clinicopathological parameters

Zanco Journal of Medical Sciences, 2019
Background and objective: Inflammatory process and genetic factors play a key role in neoplasia of colorectal cancer. Cyclooxygenase-2 is involved in a variety of important cellular functions, including cell growth and differentiation, cancer cell ...
Payman MS. Salim, Saman S. Abdulla, Jalal A. Jalal   +2 more
doaj   +1 more source