Results 161 to 170 of about 22,053,927 (171)

Cyclooxygenase-2 and its regulation in inflammation

Mediators of Inflammation, 1996
Y. S. Bakhle, R. M. Botting
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Cyclooxygenase‐2 in cancer: A review

Journal of Cellular Physiology, 2018
Cyclooxygenase‐2 (COX‐2) is frequently expressed in many types of cancers exerting a pleiotropic and multifaceted role in genesis or promotion of carcinogenesis and cancer cell resistance to chemo‐ and radiotherapy. COX‐2 is released by cancer‐associated
Nasser Hashemi Goradel, M. Najafi, Eniseh Salehi, Bagher Farhood, K. Mortezaee   +4 more
semanticscholar   +1 more source

Cyclooxygenase 2: its regulation, role and impact in airway inflammation

Clinical and Experimental Allergy, 2016
Cyclooxygenase 2 (COX‐2: official gene symbol – PTGS2) has long been regarded as playing a pivotal role in the pathogenesis of airway inflammation in respiratory diseases including asthma.
N. N. Rumzhum, A. Ammit
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Cyclooxygenase‐2 Regulates NLRP3 Inflammasome‐Derived IL‐1β Production

Journal of Cellular Physiology, 2015
The NLR family, pyrin domain‐containing 3 (NLRP3) inflammasome is a reactive oxygen species‐sensitive multiprotein complex that regulates IL‐1β maturation via caspase‐1. It also plays an important role in the pathogenesis of inflammation‐related disease.
Kuo-Feng Hua, Ju-Ching Chou, S. Ka, Y. Tasi, Ann Chen, Shih-Hsiung Wu, Hsiao-Wen Chiu, Wei-Ting Wong, Yih-Fuh Wang, Change-Ling Tsai, Chen-Lung Ho, Cheng‐Hsiu Lin   +11 more
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Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).

Journal of Medicinal Chemistry, 1997
A series of sulfonamide-containing 1,5-diarylpyrazole derivatives were prepared and evaluated for their ability to block cyclooxygenase-2 (COX-2) in vitro and in vivo.
T. Penning, J. Talley, S. Bertenshaw, J. Carter, P. Collins, S. Docter, M. Graneto, L. Lee, James W. Malecha, J. Miyashiro, R. Rogers, D. J. Rogier, S. Yu, G. Anderson, E. Burton, J. Cogburn, S. Gregory, C. Koboldt, W. Perkins, K. Seibert, A. W. Veenhuizen, Yan Y. Zhang, P. Isakson   +22 more
semanticscholar   +1 more source

Highly sensitive naphthalene-based two-photon fluorescent probe for in situ real-time bioimaging of ultratrace cyclooxygenase-2 in living biosystems.

Analytical Chemistry, 2014
Detecting and imaging of ultratrace cyclooxygenase-2 in living biosystems could provide much important valuable information for the diagnosis and intervention of cancer.
Hua Zhang, Jiangli Fan, Kui Wang, Jing Li, Caixia Wang, Yamin Nie, Tao Jiang, Huiying Mu, Xiaojun Peng, K. Jiang   +9 more
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Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2.

Journal of the American Medical Association (JAMA), 2006
CONTEXT Evidence that rofecoxib increases the risk of myocardial infarction has led to scrutiny of other nonsteroidal anti-inflammatory drugs (NSAIDs).
P. McGettigan, D. Henry
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Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma.

Journal of Hepatology, 2019
Yan Chen, Haining Chen, Kui Wang, Lu Zhang, Zhao Huang, Jiayang Liu, Zhe Zhang, Maochao Luo, Yunlong Lei, Yong Peng, Zongguang Zhou, Yuquan Wei, Canhua Huang   +12 more
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Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

Nature, 1996
R. Kurumbail, A. Stevens, J. Gierse, J. McDonald, R. Stegeman, Jina Y. Pak, Daniel Gildehaus, Julie M. iyashiro, T. Penning, K. Seibert, P. Isakson, W. Stallings   +11 more
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Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2

Nature Reviews. Cancer, 2001
Rajnish A. Gupta, R. Dubois
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