Results 191 to 200 of about 21,811,854 (372)

Suppression of Intestinal Polyposis in Apc Δ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

open access: yesCell, 1996
M. Oshima   +8 more
semanticscholar   +1 more source

Investigation for the Temperature Dependence of 2D Electron Gas Behaviors in GaN‐based Multichannel Heterostructures Systems

open access: yesAdvanced Materials Interfaces, EarlyView.
The GaN‐based multichannel heterostructures with larger band conduction difference own better temperature stability. And lattice‐matched heterostructures can improve the temperature stability of the 2D electron gas in the bottom channel. Abstract In this study, 2 electron gas(2DEG) behaviors in Al0.28Ga0.72N/GaN multichannel heterostructures with doped
Wentao Zhang   +7 more
wiley   +1 more source

BP/MoS₂ Van Der Waals Heterojunctions for Self‐Powered Photoconduction

open access: yesAdvanced Optical Materials, EarlyView.
A multilayer black phosphorus (BP)/monolayer MoS₂ vertical heterostructure is investigated using four‐probe measurements. The device exhibits rectifying behavior, dominant n‐type transport, low contact resistance, and an interface barrier of 68 meV.
Adolfo Mazzotti   +9 more
wiley   +1 more source

Expression of Cyclooxygenase-1 and Cyclooxygenase-2 in normal and pathological human oral mucosa

open access: yesFolia Histochemica et Cytobiologica, 2010
Cyclooxigenase (COX) is the rate-limiting enzyme for the conversion of arachidonic acid (AA) to prostaglandins(PGs). Two isoforms of COX have been identified: COX-1 is constitutively expressed in many cells and is involved in cellhomeostasis ...
Annamaria Mauro   +7 more
doaj  

Accelerated Bone Healing via Electrical Stimulation

open access: yesAdvanced Science, EarlyView.
Electrical stimulation significantly impacts bone healing by enhancing osteoblast proliferation, differentiation, and vascularization through calmodulin/calcineurin/NFAT signaling. It also boosts macrophage function and cell migration, presenting a comprehensive approach to accelerating bone repair.
Jianfeng Sun   +4 more
wiley   +1 more source

The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels

open access: yesAdvanced Science, EarlyView.
In breast cancer (BC), NUMB loss of function (LOF) is common and mainly driven by protein hyper‐degradation. The CRL7FBXW8 complex is the E3 ligase responsible for NUMB degradation. Inhibition of CRL7FBXW8 in NUMB‐LOF BC cells restores NUMB levels, and decreases the number of cancer stem cells and tumorigenic ability in vivo. Targeting CRL7FBXW8 offers
Simone Sabbioni   +16 more
wiley   +1 more source

Brain cyclooxygenase-2 mediates interleukin-1-induced cellular activation in preoptic and arcuate hypothalamus, but not sickness symptoms

open access: yesNeurobiology of Disease, 2010
Interleukin-1ß acts on the CNS to induce fever, neuroendocrine activation, and behavioral changes, but cannot passively cross the blood–brain barrier. According to a widely accepted hypothesis interleukin-1ß induces the synthesis of cyclooxygenase-2 at ...
Agnès Nadjar   +4 more
doaj  

Self‐Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery

open access: yesAdvanced Science, EarlyView.
Zou et al. developed an engineered strain of Escherichia coli Nissle 1917 with precise targeting abilities for colonization and on‐demand payload release. The engineered probiotic survives and embolizes tumors only in the presence of more than 5 mM L‐lactate. Furthermore, the introduction of an α‐hemolysin circuit enhances its anti‐tumor effect.
Zhen‐Ping Zou   +8 more
wiley   +1 more source

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