Results 231 to 240 of about 216,666 (331)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

PET Quantification in Healthy Humans of Cyclooxygenase-2, a Potential Biomarker of Neuroinflammation. [PDF]

J Nucl Med
Yan X, Noergaard M, Morse CL, Liow JS, Hong J, Greve D, Telu S, Kim MJ, Montero Santamaria JA, Galassi A, Feng N, Williams Avram SK, Usdin TB, Wu S, Zhang A, Manly LS, Jenkins M, Van Buskirk M, Lee A, Zoghbi SS, Pike VW, Zanotti-Fregonara P, Innis RB.   +22 more
europepmc   +1 more source

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

Association of Single Nucleotide Polymorphisms in the Cyclooxygenase-2 (COX-2) Gene with Periodontal Disease-A Systematic Review with Meta-Analysis and Implications for Personalized Dentistry. [PDF]

J Pers Med
Savva V, Fragkioudakis I, Sakellari D.
europepmc   +1 more source

Cyclooxygenase-2 expression in keratocystic odontogenic tumour decreased following decompression

, 2013
Jing Wang, Xiaomin Zhang, Xu Ding, Shuzhong Xing, Huaiqi Li, Wei Zhang, Lizhen Wang, Heming Wu   +7 more
openalex   +2 more sources

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Association of serum cyclooxygenase-2 levels with hand-foot syndrome in patients receiving capecitabine: an exploratory analysis of D-TORCH study. [PDF]

Ecancermedicalscience
Tansir G, Santhosh A, Kumar A, Baskarane H, Divakar MK, Hooda V, Dev AJR, Prasad CP, Gupta I, Kumar S, Tanwar P, Sharma A, Bakhshi S, Batra A.   +13 more
europepmc   +1 more source

Synthesis of E-stilbens as Potent Cyclooxygenase-2 Inhibitors and Identification of their Photochemical Products [PDF]

, 2014
Ahmadreza Bekhradnia, Maryam Ahmadian Moghadam, Monire Tatar   +2 more
openalex  

Device to Circuit Co‐Design Utilizing High‐Performance PEALD Indium‐Gallium‐Zinc Oxide Thin‐Film Transistor Enabling Technology Node Scaling in Monolithic 3D Systems

Advanced Science, EarlyView.
This article presents a holistic investigation of M3D‐compatible oxide semiconductor technology using PEALD‐fabricated IGZO TFTs, spanning device‐level characterization, TCAD Modeling, circuit design, and scaled‐node projections. It demonstrates high field‐effect mobility (up to 116.35 cm2 V−1·s−1), robust reliability (△VTH < 0.15 V), low variation ...
Wenhui Wang, Tao Zhang, Zelin Yuan, Haoran Peng, Jun Lan, Zhixiong Li, Yongle Wu, Xuewei Feng, Longyang Lin, Feichi Zhou, Panpan Zhang, Yida Li   +11 more
wiley   +1 more source

Effects on Oral Squamous Carcinoma Cell Lines and Their Mechanisms of Pyrazole N-Aryl Sulfonate: A Novel Class of Selective Cyclooxygenase-2 Inhibitors. [PDF]

Int J Mol Sci
Wang S, Shi M, Wang H, Zeng X, Zhang D, Zhang Z, Xu Z, Li Y.   +7 more
europepmc   +1 more source