Results 231 to 240 of about 21,811,854 (372)

Annexin A3 Represses Endothelial Permeability and Inflammation During Sepsis via Actin Cytoskeleton Modulation

Advanced Science, EarlyView.
Annexin A3 (ANXA3) plays an endogenous protective role in endothelial dysfunction in sepsis by stabilizing the actin cytoskeleton, modulating cell permeability, and inhibiting pATF2/CD62E inflammatory signaling. Abstract Increased endothelial permeability and a dysregulated inflammatory response play key roles in organ damage in sepsis.
Manyu Xing, Shuang Liang, Wei Cao, Qulian Guo, Wangyuan Zou   +4 more
wiley   +1 more source

Induction of cyclooxygenase‐2 expression in human myometrial smooth muscle cells by interleukin‐1β: involvement of p38 mitogen‐activated protein kinase

, 1999
Simon Bartlett, Robert Sawdy, Giovanni E. Mann   +2 more
openalex   +2 more sources

Chronic Treatment With Ticagrelor Limits Myocardial Infarct Size: An Adenosine and Cyclooxygenase-2–Dependent Effect

Arteriosclerosis, Thrombosis and Vascular Biology, 2014
Manjyot K. Nanhwan, S. Ling, Monica Kodakandla, S. Nylander, Y. Ye, Y. Birnbaum   +5 more
semanticscholar   +1 more source

Retraction Note: The role of cyclooxygenase-2, interleukin-1β and fibroblast growth factor-2 in the activation of matrix metalloproteinase-1 in sheared-chondrocytes and articular cartilage. [PDF]

Sci Rep
Guan PP, Guo JW, XinYu, Wang Y, Wang T, Konstantopoulos K, Wang ZY, Wang P.   +7 more
europepmc   +1 more source

Chromosome‐Level Genome Assembly of the Leafcutter Bee Megachile rotundata Reveals Its Ecological Adaptation and Pollination Biology

Advanced Science, EarlyView.
The genome of Megachile rotundata, an extensively managed solitary pollination bee species, has been sequenced, covering 280.68 Mb and predicting 10 701 genes. The study reveals significant expansions of the Toll gene family and their abundant expression in diapause prepupae, highlighting enhanced immune responses during diapause. This genome serves as
Rangjun Shi, Pan Duan, Mengmeng Zhu, Rong Zhang, Zihua Zhao, Xin Nie, Hanhou He, Li Hou, Xianhui Wang   +8 more
wiley   +1 more source

Cyclooxygenase-2 is essential for normal recovery from 5-fluorouracil–induced myelotoxicity in mice

, 1999
Meike Lorenz, Helen S. Slaughter, Debra Wescott, Sherryann I. Carter, Bruno Schnyder, Joseph Dinchuk, Bruce D. Car   +6 more
openalex   +1 more source

Cyclooxygenase-2/Prostaglandin E2 Pathway Facilitates Infectious Bronchitis Virus-Induced Necroptosis in Chicken Macrophages, a Caspase-Independent Cell Death. [PDF]

Viruses
Mahmoud ME, Tingley D, Faizal A, Ghaffar A, Azhar M, Salman D, Isham IM, Abdul-Careem MF.   +7 more
europepmc   +1 more source

Adducin‐1 Facilitates Influenza Virus Endosomal Trafficking and Uncoating by Regulating Branched Actin Dynamics and Myosin IIB Activity

Advanced Science, EarlyView.
In this study, a novel mechanism is unveiled by which ADD1, acting as a molecular switch, coordinates actin branch dynamics and the transport of endocytic viruses and cargoes. Phosphorylation of ADD1 at Ser726 reduces actin branch density, enhancing endosome fusion and attachment to microtubules.
Meijun Jiang, Jiahui Zou, Yaoming Jin, Chenjun Jiang, Shaoyu Tu, Tong Chen, Jinli Guo, Yanqing Cheng, Meilin Jin, Huanchun Chen, Hongbo Zhou   +10 more
wiley   +1 more source

PRMT1‐Mediated SWI/SNF Complex Recruitment via SMARCC1 Drives IGF2BP2 Transcription to Enhance Carboplatin Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
PRMT1 drives carboplatin resistance and tumor progression in head and neck squamous cell carcinoma (HNSCC) through a novel, methyltransferase‐independent mechanism. It recruits the SWI/SNF complex to activate IGF2BP2, promoting tumor growth and carboplatin resistance. PBX2 upregulates PRMT1, reinforcing this pathway. This study uncovers a non‐catalytic
Shixian Liu, Wentao Zhang, Weiwei Liu, Zhao Ding, Ruijing Zhang, Yuefeng Han, Zihao Niu, Mengdie Zhang, Hui Li, Dapeng Li, Zixi Wang, Jie Peng, Yu Wu, Yanxun Han, Zihui Xie, Jing Wu, Liang Qin, Zhongdong Hu, Xu Chen, Yunlong Hu, Yehai Liu, Shiyin Ma, Xiaojun Zha   +22 more
wiley   +1 more source

Profile of JTE-522 as a Human Cyclooxygenase-2 Inhibitor

, 1998
Korekiyo Wakitani, Toyomichi Nanayama, M. Masaki, Mutsuyoshi Matsushita   +3 more
openalex   +1 more source