Results 71 to 80 of about 22,053,927 (171)

The role of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide and interleukin-1 stimulated enterocyte prostanoid formation

Mediators of Inflammation, 1998
Lipopolysaccharide is an inflammatory agent and interleukin-1 is a cytokine. Their pro-inflammatory effects may be mediated by prostanoids produced by inducible cyclooxygenase-2.
W. E. Longo, L. J. Damore, J. E. Mazuski, G. S. Smith, N. Panesar, D. L. Kaminski   +5 more
doaj   +1 more source

Antitumor enhancement of celecoxib, a selective Cyclooxygenase-2 inhibitor, in a Lewis lung carcinoma expressing Cyclooxygenase-2

Journal of Experimental & Clinical Cancer Research, 2008
Background The goal of this study was to determine the effects of a selective Cyclooxygenase (COX)-2 inhibitor on the inhibition of tumor growth and pulmonary metastasis in a Lewis Lung Carcinoma (LLC) animal model. Methods For immunoblot analysis of COX-
Han Jae, Oh Young, Park Won, Pyo Hongryull   +3 more
doaj   +1 more source

Discrimination of Naturally-Occurring 2-Arylbenzofurans as Cyclooxygenase-2 Inhibitors: Insights into the Binding Mode and Enzymatic Inhibitory Activity

Biomolecules, 2020
2-arylbenzofuran-containing compounds are chemical entities that can be naturally produced by several organisms. A wide-range of activities is described for several compounds of this kind and they are, therefore, valuable moieties for a lead finding from
Ericsson Coy-Barrera
doaj   +1 more source

Canonical Forms of $2 \times 2 \times 2$ and $2 \times 2 \times 2 \times 2$ Symmetric Tensors over Prime Fields [PDF]

arXiv, 2012
We consider symmetric tensors of format $2 \times 2 \times 2$ and $2 \times 2 \times 2 \times 2$ over prime fields. Using computer algebra we compute the canonical forms of these tensors. For $2 \times 2 \times 2$ symmetric tensors, we consider the prime fields $\mathbb{F}_p$ for $p = 2, 3, 5, 7, 11, 13, 17$.
arxiv  

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

Proceedings of the National Academy of Sciences of the United States of America, 1994
We have examined the role of cyclooxygenase 2 (COX-2) in a model of inflammation in vivo. Carrageenan administration to the subcutaneous rat air pouch induces a rapid inflammatory response characterized by high levels of prostaglandins (PGs) and ...
J. Masferrer, Bs Zweifel, Pt Manning, Sd Hauser, Km Leahy, W. Byron Smith, P. Isakson, K. Seibert   +7 more
semanticscholar   +1 more source

Cyclooxygenase-2 Expression in Gastric Antral Mucosa Before and After Eradication of Helicobacter Pylori Infection [PDF]

, 1999
Conor McCarthy, Leslie J. Crofford, Joel K. Greenson, James M. Scheiman   +3 more
openalex   +2 more sources

Cyclooxygenase-2 inhibitors: promise or peril?

Mediators of Inflammation, 2002
The discovery of two isoforms of the cyclooxygenase enzyme, COX-1 and COX-2, and the development of COX-2-specific inhibitors as anti-inflammatories and analgesics have offered great promise that the therapeutic benefits of NSAIDs could be optimized ...
Laurel J. Mengle-Gaw, Benjamin D. Schwartz   +1 more
doaj   +1 more source

Saturated Fatty Acids, but Not Unsaturated Fatty Acids, Induce the Expression of Cyclooxygenase-2 Mediated through Toll-like Receptor 4*

Journal of Biological Chemistry, 2001
Results from our previous studies demonstrated that activation of Toll-like receptor 4 (Tlr4), the lipopolysaccharide (LPS) receptor, is sufficient to induce nuclear factor κB activation and expression of inducible cyclooxygenase (COX-2) in macrophages ...
J. Lee, K. Sohn, S. Rhee, D. Hwang
semanticscholar   +1 more source

Phosphatidylinositol transfer protein α regulates growth and apoptosis of NIH3T3 cells

Journal of Lipid Research, 2004
Mouse fibroblast cells overexpressing phosphatidylinositol transfer protein α [PI-TPα; sense PI-TPα (SPIα) cells] show a significantly increased rate of proliferation and an extreme resistance toward ultraviolet- or tumor necrosis factor-α-induced ...
Martijn Schenning, Claudia M. van Tiel, Daniëlle van Manen, Jord C. Stam, Barend M. Gadella, Karel W.A. Wirtz, Gerry T. Snoek   +6 more
doaj  

Human Intelectin-1 (hITL-1) as Modulator of Metabolic Syndrome (MetS): An In Silico Study

Journal of Pharmacy and Bioallied Sciences
Human intelectin-1 (hITL-1) has been known to be involved in diseases such as asthma, cancer, metabolic disorders, and inflammatory bowel disease. In the present study, we aimed to evaluate hITL-1 as modulator of metabolic syndrome (MetS) using an in ...
Vishnupriya N, Narayanaswamy Radhakrishnan   +1 more
doaj   +1 more source