Results 81 to 90 of about 21,811,854 (372)
Detection of non-melanoma skin cancer by in vivo fluorescence imaging with fluorocoxib A. [PDF]
, 2015 Non-melanoma skin cancer (NMSC) is the most common form of cancer in the US and its incidence is increasing. The current standard of care is visual inspection by physicians and/or dermatologists, followed by skin biopsy and pathologic confirmation.
Ali-Khan, Irfan +8 more
core +2 more sources
Molecular Oncology, EarlyView.Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley +1 more source
Cyclooxygenase-2 and the inflammogenesis of breast cancer.
World Journal of Clinical Oncology, 2014 Cohesive scientific evidence from molecular, animal, and human investigations supports the hypothesis that constitutive overexpression of cyclooxygenase-2 (COX-2) is a ubiquitous driver of mammary carcinogenesis, and reciprocally, that COX-2 blockade has
Randall Harris, B. Casto, Z. Harris
semanticscholar +1 more source
Cardiac remodelling hinders activation of cyclooxygenase-2, diminishing protection by delayed pharmacological preconditioning: role of HIF1α and CREB [PDF]
, 2017 Aims We tested whether delayed pharmacologic preconditioning elicited by isoflurane is protective in infarct-remodelled hearts. Methods and results Male Wistar rats were treated with the preconditioning drug isoflurane 6 weeks after permanent ligation of
Feng, Jianhua +6 more
core
Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response [PDF]
, 2002 Objective: Cyclooxygenase (COX)-2 is a key regulatory enzyme in the synthesis of prostanoids associated with trauma and inflammation. We investigated the COX-2 gene for functional variants that may influence susceptibility to disease.
Brull, D.J. +6 more
core +1 more source
Molecular Oncology, EarlyView.Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien +7 more
wiley +1 more source
A structure-based drug design approach for the identification of novel selective Cyclooxygenase-2 inhibitors using resveratrol analogues as lead molecules [PDF]
, 2015 Therapeutic areas for selective cyclooxygenase-2 inhibitors include inflammatory conditions and cancer. A study has demonstrated that hydroxylated analogues of resveratrol, which is found in red wine, inhibit cyclooxygenase-2 selectively.
Caruana, Clarissa, Shoemake, Claire
core
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source
Cyclooxygenase-2 Immunoexpression in Invasive Breast Carcinoma: A Possible Prognostic Factor
Advanced Medical Journal, 2023 Background and objectives:cyclooxygenase-2 is well known to be overexpressed in breast cancer and it plays nega- tive effects on tumor growth and progression.
Maryam Abdulmajed Muhammad Ameen +2 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 1994 Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used for the treatment of inflammatory diseases, but significant side effects such as gastrointestinal erosion and renal damage limit their use. NSAIDs inhibit the enzyme cyclooxygenase (COX), which
K. Seibert +7 more
semanticscholar +1 more source