Results 221 to 230 of about 112,794 (342)

Prediction of the potency of mammalian cyclooxygenase inhibitors with ensemble proteochemometric modeling. [PDF]

J Cheminform, 2015
Cortes-Ciriano I, Murrell DS, van Westen GJ, Bender A, Malliavin TE.   +4 more
europepmc   +1 more source

Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitors

, 2014
Jagdeep Grover, Vivek Kumar, Vikram Singh, Khemraj Bairwa, M. Elizabeth Sobhia, Sanjay M. Jachak   +5 more
openalex   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

An agent that releases basophil and mast cell histamine but blocks cyclooxygenase and lipoxygenase metabolism of arachidonic acid inhibits immunoglobulin E-mediated asthma in rhesus monkeys

, 1981
Roy Patterson, Jacob J. Pruzansky, Kathleen E. Harris   +2 more
openalex   +1 more source

Cyclooxygenase-2 Inhibitor Treatment Improves Left Ventricular Function and Mortality in a Murine Model of Doxorubicin-Induced Heart Failure [PDF]

, 2004
Reynolds M. Delgado, Mohamad A. Nawar, Aly Zewail, Biswajit Kar, William K. Vaughn, Kenneth K. Wu, Nena Aleksic, Natarajan Sivasubramanian, Kathleen E. McKay, Douglas L. Mann, James T. Willerson   +10 more
openalex   +1 more source

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

Allosteric regulation of prostaglandin endoperoxide H₂ synthases. [PDF]

J Biol Chem
Dong L, Malkowski MG.
europepmc   +1 more source

Synthesis, Biological Evaluation, and Enzyme Docking Simulations of 1,5-Diarylpyrrole-3-Alkoxyethyl Ethers as Selective Cyclooxygenase-2 Inhibitors Endowed with Anti-inflammatory and Antinociceptive Activity

, 2008
Maurizio Anzini, Michele Rovini, Andrea Cappelli, Salvatore Vomero, Fabrizio Manetti, Maurizio Botta, Lidia Sautebin, Antonietta Rossi, Carlo Pergola, Carla Ghelardini, Monica Norcini, Antonio Giordani, Francesco Makovec, Paola Anzellotti, Paola Patrignani, Mariangela Biava   +15 more
openalex   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Conjugates of cisplatin and cyclooxygenase inhibitors as potent antitumor agents overcoming cisplatin resistance. [PDF]

ChemMedChem, 2014
Neumann W, Crews BC, Marnett LJ, Hey-Hawkins E.   +3 more
europepmc   +1 more source