Results 201 to 210 of about 112,794 (342)

Suppression of azoxymethane‐induced colon cancer development in rats by a cyclooxygenase‐1 selective inhibitor, mofezolac [PDF]

, 2006
Naoko Niho, Tomohiro Kitamura, Mami Takahashi, Michihiro Mutoh, Hidetaka Sato, Mamoru Matsuura, Takashi Sügimura, Keiji Wakabayashi   +7 more
openalex   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

The effect of selective and non-selective cyclooxygenase inhibitors and nitric oxide on renal ischaemia-reperfusion injury in the normotensive and hypertensive rat.

, 2003
S E Knight
openalex   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

Derivation and Evaluation of Putative Adverse Outcome Pathways for the Effects of Cyclooxygenase Inhibitors on Reproductive Processes in Female Fish. [PDF]

Toxicol Sci, 2017
Martinovic-Weigelt D, Mehinto AC, Ankley GT, Berninger JP, Collette TW, Davis JM, Denslow ND, Durhan EJ, Eid E, Ekman DR, Jensen KM, Kahl MD, LaLone CA, Teng Q, Villeneuve DL.   +14 more
europepmc   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Variations in Essential Oil Compositions and Cyclooxygenase (COX) Inhibiting Potential of Ruta chalepensis L. Essential Oils Obtained at Different Phenological Stages

İlker Demirbolat
openalex   +2 more sources

Design, synthesis, anti-inflammatory activity and molecular docking of potential novel antipyrine and pyrazolone analogs as cyclooxygenase enzyme (COX) inhibitors

, 2018
Mardia T. El Sayed, Marwa A.M.Sh. El‐Sharief, Eman S. Zarie, Nesrin M. Morsy, Ahmed R. El‐Sheakh, Andrey Voronkov, Vladimir P. Berishvili, Ghada S. Hassan   +7 more
openalex   +1 more source

Nonaspirin NSAIDs, Cyclooxygenase 2 Inhibitors, and the Risk for Stroke [PDF]

, 2008
Christianne L. Roumie, Edward F. Mitchel, Lisa A. Kaltenbach, Patrick G. Arbogast, Patricia Gideon, Marie R. Griffin   +5 more
openalex   +1 more source

Dual‐Targeting Cuproptosis and Mitophagy via a Flavopiridol‐Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma

Advanced Science, EarlyView.
This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren, Zhihong Deng, Sheng Lu, Jing Zhang, Wenbin Liu, Jia Tan   +5 more
wiley   +1 more source