Results 291 to 300 of about 2,867,692 (324)
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Cyclooxygenase-2 Inhibitors: A Painful Lesson
Cardiovascular & Hematological Disorders-Drug Targets, 2006Non-steroidal anti-inflammatory drugs (NSAIDs) represent a clinically important class of agents. NSAIDs are commonly used in treatment of conditions such as headache, fever, inflammation and joint pain. Complications often arise from chronic use of NSAIDs.
Sheldon Chaffer +6 more
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Equine Veterinary Journal, 2010
REASONS FOR PERFORMING STUDY Recent studies have shown that flunixin prevented recovery of equine jejunum post ischaemia. However, the use of a purported cyclooxygenase (COX)-2 preferential inhibitor, etodolac, also prevented recovery. These findings may
J. Tomlinson, A. Blikslager
semanticscholar +1 more source
REASONS FOR PERFORMING STUDY Recent studies have shown that flunixin prevented recovery of equine jejunum post ischaemia. However, the use of a purported cyclooxygenase (COX)-2 preferential inhibitor, etodolac, also prevented recovery. These findings may
J. Tomlinson, A. Blikslager
semanticscholar +1 more source
Efficacy of cyclooxygenase-2–specific inhibitors
The American Journal of Medicine, 2001Conventional nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). The clinical efficacy of NSAIDs is primarily related to the inhibition of COX-2 activity, whereas much of the toxicity, particularly gastrointestinal toxicity, is related to COX-1 inhibition.
Grant W. Cannon, Ferdinand C. Breedveld
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Cyclooxygenase inhibitors: drugs for cancer prevention
Current Opinion in Pharmacology, 2003Evidence that chronic intake of non-steroidal anti-inflammatory drugs, especially aspirin, prevents cancer development continues to accumulate. The data are particularly convincing for colorectal cancer; however, because of well-known side effects, they cannot routinely be recommended for this purpose.
Santini Dl +2 more
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Journal of the American Medical Association (JAMA), 2006
CONTEXT Evidence that rofecoxib increases the risk of myocardial infarction has led to scrutiny of other nonsteroidal anti-inflammatory drugs (NSAIDs).
P. McGettigan, D. Henry
semanticscholar +1 more source
CONTEXT Evidence that rofecoxib increases the risk of myocardial infarction has led to scrutiny of other nonsteroidal anti-inflammatory drugs (NSAIDs).
P. McGettigan, D. Henry
semanticscholar +1 more source
Cyclooxygenase-2 Inhibitors in Glioma Therapy
American Journal of Therapeutics, 2004The cyclooxygenase enzyme is a prostaglandin synthase that has two isoforms, cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Upregulation of the COX-2 isoform in many cancers has led to investigation regarding the potential role of this enzyme in oncogenesis.
Victor A. Levin, Pierre Giglio
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Cochrane Database of Systematic Reviews, 2008
BACKGROUND Patent ductus arteriosus (PDA) with significant left to right shunt in preterm infants increases morbidity and mortality. Early closure of the ductus arteriosus may be achieved pharmacologically using cyclooxygenase inhibitors or by surgery ...
M. Malviya, A. Ohlsson, Sachin S Shah
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BACKGROUND Patent ductus arteriosus (PDA) with significant left to right shunt in preterm infants increases morbidity and mortality. Early closure of the ductus arteriosus may be achieved pharmacologically using cyclooxygenase inhibitors or by surgery ...
M. Malviya, A. Ohlsson, Sachin S Shah
semanticscholar +1 more source
[Pharmacology and classification of cyclooxygenase inhibitors].
Gastroenterologie clinique et biologique, 2004The discovery of at least two cyclooxygenase (COX) isoenzymes had two major consequences: i) to give a new impetus to the research on lipid metabolism, giving rise to the crystallization of these peculiar membrane enzymes, the characterization of their active sites and their gene regulation, and the identification of new metabolic pathways; ii) the ...
Jouzeau, Jean-Yves +3 more
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Selective cyclooxygenase-2 inhibitors
La Presse Médicale, 2005Resume Objectifs L’utilisation des inhibiteurs selectifs de la cyclo-oxygenase 2 (coxibs) est actuellement contestee, en particulier en raison des risques cardiovasculaires. Peu de travaux ont evalue leurs conditions reelles d’utilisation. Cette etude avait pour buts de mesurer l’evolution des conditions reelles d’utilisation des coxibs en France et
Guy-Robert Auleley +3 more
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Selective inhibitors of cyclooxygenase-2
Expert Opinion on Therapeutic Patents, 1997Prostaglandins (PGs) produced by the inducible enzyme cyclooxygenase-2 (COX-2) are important mediators of pain and inflammation. In animals, selective inhibitors of COX-2 have been shown to be anti-inflammatory without typical non-steroidal anti-inflammatory drug (NSAID) side-effects. Research directed towards the identification of potent and selective
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