Results 301 to 310 of about 114,365 (325)
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Selective cyclooxygenase-2 inhibitors
La Presse Médicale, 2005Resume Objectifs L’utilisation des inhibiteurs selectifs de la cyclo-oxygenase 2 (coxibs) est actuellement contestee, en particulier en raison des risques cardiovasculaires. Peu de travaux ont evalue leurs conditions reelles d’utilisation. Cette etude avait pour buts de mesurer l’evolution des conditions reelles d’utilisation des coxibs en France et
Guy-Robert Auleley +3 more
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Cyclooxygenase-2 Inhibitors in Lung Cancer
Clinical Lung Cancer, 2004Prostanoids produced by the arachidonic acid pathway play an important role in multiple stages of carcinogenesis and progression of cancer. Cyclooxygenase (COX), which exists in 2 isoforms, is the rate-limiting enzyme in the COX pathway. Cyclooxygenase-1 is constitutively expressed in normal tissues and is essential for several important physiologic ...
Sakkaraiappan, Ramalingam +1 more
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Clinical experience with cyclooxygenase-2 inhibitors
Inflammation Research, 1999Increasing amounts of experimental and clinical data support the role of selective cyclooxygenase (COX)-2 inhibition in anti-inflammatory processes and the role of COX-1 inhibition in increasing the frequency of side effects. This article reviews the regulation of COX-2 in inflammatory processes based on in vitro and in vivo work.
J, van Ryn, M, Pairet
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Rofecoxib: A specific cyclooxygenase inhibitor
Drugs of Today, 2000Rofecoxib is a new specific cyclooxygenase-2 inhibitor. The efficacy of rofecoxib has been established in the treatment of osteoarthritis, rheumatoid arthritis and acute pain. Rofecoxib has been approved in the United States for the treatment of osteoarthritis and acute pain. Endoscopically proven gastrointestinal ulceration is much less with rofecoxib
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Cyclooxygenase-2 inhibitors in colorectal cancer
Seminars in Oncology, 2003Cyclooxygenase (COX) enzyme-dependent arachidonic acid metabolites occupy key positions in important physiologic processes such as immunity, reproduction, and vascular integrity. Large retrospective and prospective population-based studies have shown that the use of both nonselective, nonsteroidal anti-inflammatory drugs and selective COX-2 inhibitors ...
Jan, Stoehlmacher, Heinz-Josef, Lenz
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Cyclooxygenase-2 Inhibitors in Glioma Therapy
American Journal of Therapeutics, 2004The cyclooxygenase enzyme is a prostaglandin synthase that has two isoforms, cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Upregulation of the COX-2 isoform in many cancers has led to investigation regarding the potential role of this enzyme in oncogenesis.
Pierre, Giglio, Victor, Levin
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Cyclooxygenase inhibitors: drugs for cancer prevention
Current Opinion in Pharmacology, 2003Evidence that chronic intake of non-steroidal anti-inflammatory drugs, especially aspirin, prevents cancer development continues to accumulate. The data are particularly convincing for colorectal cancer; however, because of well-known side effects, they cannot routinely be recommended for this purpose.
Steven J, Shiff +2 more
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The classification of cyclooxygenase inhibitors.
The Journal of rheumatology, 1998Item does not contain ...
Lipsky, P.E. +5 more
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