Results 81 to 90 of about 114,365 (325)

Bronchopulmonary Dysplasia in Premature Infants: Pathogenesis, Clinical Picture, Treatment and Prevention (Part 1)

Zdorovʹe Rebenka, 2013
The article describes the current views on the pathogenesis, clinical picture, diagnosis and treatment of bronchopulmonary dysplasia. Special attention is paid to the influence of ductus arteriosus on the occurrence and severity of bronchopulmonary ...
V.I. Snysar, O.I. Obolonsky, D.M. Surkov, O.G. Kapustina, D.G. Volkov   +4 more
doaj   +1 more source

The Role of PPARgamma in the Cyclooxygenase Pathway in Lung Cancer. [PDF]

, 2008
Decreased expression of peroxisome proliferator activated receptor-gamma (PPARgamma) and high levels of the proinflammatory enzyme cyclooxygenase-2 (COX-2) have been observed in many tumor types.
Dubinett, Steven M, Hazra, Saswati, Mao, Jenny T, Peebles, Katherine A, Sharma, Sherven   +4 more
core  

Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response [PDF]

, 2002
Objective: Cyclooxygenase (COX)-2 is a key regulatory enzyme in the synthesis of prostanoids associated with trauma and inflammation. We investigated the COX-2 gene for functional variants that may influence susceptibility to disease.
Brull, D.J., Hill, M.R., Humphries, S.E., Laurent, G.J., Marshall, R.P., McAnulty, R.J., Papafili, A.   +6 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Effect of paracetamol and celecoxib on the state of hemocoagulation in the most acute period of heat injury in rats

Medičnì Perspektivi
 Acute heat injury (AHI) occurs due to exposure to high environmental temperatures and is considered a dangerous condition that requires effective prevention and treatment.
P.O. Chuykova, S.Yu. Shtrygol’, I.O. Lebedynets, D.V. Lytkin   +3 more
doaj   +1 more source

Bronchopulmonary Dysplasia in Premature Infants: Pathogenesis, Clinical Picture, Treatment and Prevention (Part 2)

Zdorovʹe Rebenka, 2013
The article describes the current views on the pathogenesis, clinical picture, diagnosis and treatment of bronchopulmonary dysplasia. Special attention is paid to the influence of ductus arteriosus on the occurrence and severity of bronchopulmonary ...
V.I. Snysar, O.I. Obolonsky, D.M. Surkov, O.G. Kapustina, D.G. Volkov   +4 more
doaj   +1 more source

Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia [PDF]

, 2014
© The Author 2014. Published by Oxford University Press This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution,
Al-Mahdawi, Al-Mahdawi, Block, Campuzano, Campuzano, Capdevila, Capdevila, Castaldo, Chantrel-Groussard, Chen, Cossee, Dewitt, Durr, Durr, Feng, Genki Hayashi, Gino Cortopassi, Harding, John W. Newman, Kang, Koeppen, Li, Liang, Lin, Lu, Mark Pook, Masi, Michael, Miranda, Node, O'Flaherty, Paupe, Piemonte, Piro, Praticò, Qin, Ristow, Rojo, Samuelsson, Sanchez-Mejia, Schulz, Shan, Shi, Shin, Small, Smith, Strokin, Tan, Teismann, Theresa L. Pedersen, Tian, Wardlaw, Wong, Wong, Xi, Yan, Yan Shen, Zhang   +57 more
core   +2 more sources

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Effect of celecoxib and paracetamol on the functional state of the central nervous system, pain sensitivity, and physical endurance of rats with acute heat injury

Medičnì Perspektivi
Acute heat injury (AHI) is a serious condition caused by an excessive increase in body temperature, usually due to prolonged exposure to high environmental temperatures or intense physical activity in the heat.
P.O. Chuikova , S.Yu. Shtrygol’
doaj   +1 more source

Polyunsaturated fatty acid-derived lipid mediators and T cell function [PDF]

, 2014
Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY) .
Marelli-Berg, F, Mauro, C, Nicolaou, A, Urquhart, P   +3 more
core   +3 more sources