Results 111 to 120 of about 827 (152)
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RS cyclophilins: Identification of an NK-TR1-related cyclophilin
Gene, 1996We report the isolation of a large cyclophilin protein containing RS (arginine-serine) repeats from a yeast two-hybrid screen using ClK (CDC28/cdc2-like kinase) as a probe. This Clk associating RS-cyclophilin (CARS-Cyp) possesses 39% homology to the NK-TR1 (natural killer tumor recognition protein-1) we have previously characterized (Anderson et al ...
F P, Nestel +4 more
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Cyclophilin of Schistosoma japonicum
The Journal of Parasitology, 1992A 623-bp cDNA molecule encoding cyclophilin, a specific cyclosporin A-binding protein, has been isolated from Schistosoma japonicum using a heterologous cDNA probe from Echinococcus granulosus. The nucleotide sequence of this molecule has been determined, and the deduced amino acid sequence has revealed extensive homology with homologues of other ...
V P, Argaet, G F, Mitchell
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Clinics in Liver Disease, 2009
The percentage of patients chronically infected with hepatitis C virus (HCV) who have reached sustained antiviral response has increased since the introduction of the pegylated interferon-alpha (pIFNa) and ribavirin (RBV) treatment. However, the current standard pIFNa/RBV therapy not only has a low success rate (about 50%) but is often associated with ...
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The percentage of patients chronically infected with hepatitis C virus (HCV) who have reached sustained antiviral response has increased since the introduction of the pegylated interferon-alpha (pIFNa) and ribavirin (RBV) treatment. However, the current standard pIFNa/RBV therapy not only has a low success rate (about 50%) but is often associated with ...
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Sequence conservation of schistosome cyclophilins
Molecular and Biochemical Parasitology, 1996Sequence conservation of schistosome ...
Klinkert Mq +4 more
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Role of Cyclophilins in Somatolactogenic Action
Annals of the New York Academy of Sciences, 2000Abstract: Prolactin (PRL) and growth hormone (GH) are members of the somatolactogenic hormone family, the pleiotropic actions of which are necessary for vertebrate growth and mammary differentiation. The basis for the specific function of these hormones has remained uncertain; however, their action is associated with internalization and translocation ...
M A, Rycyzyn, C V, Clevenger
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Oligopeptide cyclophilin inhibitors: A reassessment
European Journal of Medicinal Chemistry, 2011Potent cyclophilin A (CypA) inhibitors such as non-immunosuppressive cyclosporin A (CsA) derivatives have been already used in clinical trials in patients with viral infections. CypA is a peptidyl prolyl cis/trans isomerase (PPIase) that catalyzes slow prolyl bond cis/trans interconversions of the backbone of substrate peptides and proteins.
Michael, Schumann +4 more
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Functional aspects of extracellular cyclophilins
Biological Chemistry, 2014Abstract The cyclophilin family of peptidyl prolyl cis/trans isomerases includes several isoforms found to be secreted in response to different stimuli, thus existing both in the interior and the exterior of cells. The extracellular fractions of the cyclophilins CypA and CypB are involved in the control of cell-cell communication.
Henrik, Hoffmann +1 more
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Role of Cyclophilin A in HIV Replication
Future Virology, 2006A review. More than a decade has passed since the discovery that the peptidyl prolyl isomerase cyclophilin A (CypA) specifically binds to a proline-rich sequence in HIV-1 capsid (CA) and is thereby incorporated into viral particles. Since then, a variety of possible functions of CypA in the HIV-1 replication cycle have been intensively investigated ...
Votteler, J., Wray, V., Schubert, U.S.
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Cyclophilin D as a Drug Target
Current Medicinal Chemistry, 2003The mitochondrial permeability transition (MPT) plays an important role in damage-induced cell death, and agents inhibiting the MPT may have a therapeutic potential for treating human conditions such as ischemia/reperfusion injury, trauma, and neurodegenerative diseases.
Peter C, Waldmeier +4 more
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Redox regulation of cyclophilin A by glutathionylation
PROTEOMICS, 2006AbstractUsing redox proteomics techniques to characterize the thiol status of proteins in human T lymphocytes, we identified cyclophilin A (CypA) as a specifically oxidized protein early after mitogen activation. CypA is an abundantly expressed cytosolic protein, target of the immunosuppressive drug cyclosporin A (CsA), for which a variety of functions
Ghezzi, Pietro +14 more
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