Cyclophilin b - Open Access .click

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Evidence that human milk isolated cyclophilin B corresponds to a truncated form

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1996
Cyclophilin B (CyPB) is a member of the cyclophilin family (cyclosporin A-binding proteins) with specific N- and C-terminal extensions. In contrast to cyclophilin A, CyPB owns a signal sequence leading to its translocation in the endoplasmic reticulum. CyPB was reported to be present in human blood and milk, suggesting it is secreted. For this purpose,
C, Mariller, F, Allain, M, Kouach, G, Spik +3 more
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Calcium signalling in T cells stimulated by a cyclophilin B-binding protein

Nature, 1994
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin, cyclosporin A binds and inactivates the key signalling intermediate calcineurin. To identify potential cellular homologues of cyclosporin A that might regulate calcium signalling,
R J, Bram, G R, Crabtree
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Cyclophilin B Binding to Platelets Supports Calcium-Dependent Adhesion to Collagen

Blood, 1999
We have recently reported that cyclophilin B (CyPB), a secreted cyclosporine-binding protein, could bind to T lymphocytes through interactions with two types of binding sites. The first ones, referred to as type I, involve interactions with the conserved domain of CyPB and promote the endocytosis of surface-bound ligand, while the second type of ...
F, Allain +4 more
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[787] THE REDUCTION OF BOTH CYCLOPHILIN B AND HCV-RNA BY THE CYCLOPHILIN INHIBITOR DEBIO-025 CONFIRMS THE IMPORTANCE OF CYCLOPHILIN B FOR HCV REPLICATION IN MAN