Results 111 to 120 of about 4,905 (211)

The Prolyl Isomerase Pin1 in Breast Development and Cancer [PDF]

, 2011
The prolyl isomerase Pin1 specifically isomerizes certain phosphorylated Ser/Thr-Pro bonds and thereby regulates various cellular processes. Pin1 is a target of several oncogenic pathways and is overexpressed in human breast cancer.
Liou, Yih-Cherng, Lu, Kun Ping, Ryo, Akihide, Wulf, Gerburg Maria   +3 more
core  

Management of cytoskeleton architecture by molecular chaperones and immunophilins [PDF]

, 2011
Cytoskeletal structure is continually remodeled to accommodate normal cell growth and to respond to pathophysiological cues. As a consequence, several cytoskeleton-interacting proteins become involved in a variety of cellular processes such as cell ...
Adachi, Albanese, Alejandra G. Erlejman, Ammer, Aravind, Aylett, Bailey, Banerjee, Basso, Bechtold, Beck, Benndorf, Bercovich, Bivi, Bjorkdahl, Bork, Brackley, Brackley, Broadley, Buee, Burke, Byrd, Cabeen, Capetanaki, Chadli, Chambraud, Chambraud, Chan, Cheung, Cheung, Cheung, Colo, Cox, Creppe, Csermely, Cuellar, Czar, Czar, Czar, Dabir, Davies, Defeu Soufo, Dekker, DeZwaan, Dickey, Ding, Donnelly, Dou, Duan, Dunn, Dutsch-Wicherek, Echeverria, Ehler, Elbi, Elliott, Ellis, Erickson, Feldman, Fisher, Fisher, Fortugno, Fulda, Galigniana, Galigniana, Galigniana, Galigniana, Galigniana, Galigniana, Galigniana, Galigniana, Galigniana, Gallo, Gao, Gilyarov, Gold, Gold, Goldbaum, Goldfarb, Gong, Graciela Piwien-Pilipuk, Grad, Grantham, Green, Gross, Guillozet-Bongaarts, Hammond, Harrell, Hartl, Herrmann, Hinds, Horwich, Hotulainen, Hut, Héctor R. Quintá, Jakob, Jana, Jinwal, Jo, Kadota, Kampinga, Kanelakis, Kang, Karagoz, Kaverina, Khatau, Klucken, Kostenko, Kovacs, Kubota, Lange, Lavoie, Lavoie, Lee, Liao, Lin, Liu, Liu, Luo, Luo, Mariana Lagadari, Mario D. Galigniana, Mayer, Meierhofer, Michie, Mogilner, Morimoto, Muchowski, Murphy, Natalia M. Galigniana, Neckers, Omary, Pallari, Park, Perrot-Applanat, Pratt, Pratt, Pratt, Quinta, Quintá, Reed, Richter, Rycyzyn, Sah, Sahara, Salminen, Sarria, Sausville, Sellin, Shih, Shim, Shimamoto, Shimura, Silverstein, Silverstein, Sinars, Solit, Spiess, Sreedhar, Szeverenyi, Tam, Tanioka, Thomas, Thulasiraman, Toivola, Toivola, Trepel, Van den Abbeele, Vaughan, Verhey, Vicent, Vogel, Wade, Weaver, Weis, Westermann, Wiesner, Wirtz, Wright, Wu, Zhai, Zhao, Zilberman   +181 more
core   +1 more source

Blood–Brain Barrier: Structure, Function, Diseases, and Drug Delivery Systems

MedComm, Volume 7, Issue 4, April 2026.
This graphical abstract illustrates how blood–brain barrier‐targeted nanomedicine integrates diverse nanocarrier platforms with mechanism‐based therapeutic strategies to overcome delivery barriers in ischemic stroke, enabling targeted modulation of oxidative stress, inflammation, excitotoxicity, and neuronal survival.
Yanan He, Mengyao Qu, Lu Yu, Lipeng He, Yixun Lu, Jin Hong, Miao Sun, Huikai Yang, Weidong Mi, Hang Guo, Yulong Ma   +10 more
wiley   +1 more source

Bioinformatic and expression analysis of the Brassica napus L. cyclophilins

Scientific Reports, 2017
Cyclophilins (CYPs) are a group of ubiquitous proteins characterized by their ability to bind to the immunosuppressive drug cyclosporin A. The CYP family occurs in a wide range of organisms and contains a conserved peptidyl-prolyl cis/trans isomerase ...
Patrizia Hanhart, Melanie Thieß, Khalid Amari, Krzysztof Bajdzienko, Patrick Giavalisco, Manfred Heinlein, Julia Kehr   +6 more
doaj   +1 more source

The structure of TTHA0988 from Thermus thermophilus, a KipI-KipA homologue incorrectly annotated as allophanate hydrolase [PDF]

, 2011
The Thermus thermophilus protein TTHA0988 is a protein of unknown function which represents a fusion of two proteins found almost ubiquitously across the bacterial kingdom.
Guss, J. Mitchell, Jacques, David. A., Kuramitsu, Seiki, Langley, David B., Trewhella, Jill, Yokoyama, Shigeyuki   +5 more
core   +2 more sources

Disulfide Crosslinking Induces Rapid Degradation of Arc/Arg3.1 via Hsp70‐Mediated Ubiquitin Ligase Pathway

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Heat shock induces Arc/Arg3.1 Cys34‐Cys159 disulfide crosslinking, promoting oligomerization and Hsp70‐CHIP‐dependent ubiquitination followed by proteasomal degradation during recovery. Disrupting disulfide formation (C159A) impairs CHIP‐mediated ubiquitination and stabilizes Arc/Arg3.1, whereas HSF1 loss limits inducible Hsp70 and leads to Arc ...
Dami So, In‐Kang Song, Yeon Jung Kim, Yeonjoo Lee, Yeon Seung Park, Hee‐Jung Kim, Kong‐Joo Lee, Eun Joo Song   +7 more
wiley   +1 more source

The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors.

PLoS Pathogens, 2011
Coronaviruses (CoVs) are important human and animal pathogens that induce fatal respiratory, gastrointestinal and neurological disease. The outbreak of the severe acute respiratory syndrome (SARS) in 2002/2003 has demonstrated human vulnerability to ...
Susanne Pfefferle, Julia Schöpf, Manfred Kögl, Caroline C Friedel, Marcel A Müller, Javier Carbajo-Lozoya, Thorsten Stellberger, Ekatarina von Dall'Armi, Petra Herzog, Stefan Kallies, Daniela Niemeyer, Vanessa Ditt, Thomas Kuri, Roland Züst, Ksenia Pumpor, Rolf Hilgenfeld, Frank Schwarz, Ralf Zimmer, Imke Steffen, Friedemann Weber, Volker Thiel, Georg Herrler, Heinz-Jürgen Thiel, Christel Schwegmann-Wessels, Stefan Pöhlmann, Jürgen Haas, Christian Drosten, Albrecht von Brunn   +27 more
doaj   +1 more source

The human FK506-binding proteins: characterization of human FKBP19 [PDF]

, 2006
Analysis of the human repertoire of the FK506-binding protein (FKBP) family of peptidyl-prolyl cis/trans isomerases has identified an expansion of genes that code for human FKBPs in the secretory pathway.
A Galat, A Galat, A Pahl, AN Fedorov, CE Patterson, CE Patterson, Colin Robinson, DA Peattie, DS Horowitz, E Lam, E Pennisi, EC Davis, EK Baker, G Fischer, G Heijne von, H Arakawa, H Inoue, Hilda Tateossian, JD Thompson, JE Kay, JE Kay, JJ Siekierka, JJ Siekierka, John E. Kay, K Ishikawa, K Nakai, KT Bush, Lucy Gettins, M Shadidy, N Kuzhandaivelu, R Ranganathan, RD Teasdale, RF Standaert, Ross A. Kinloch, S Munro, SC Nair, Stuart L. Rulten, SW Michnick, T Nakamura, T Ratajczak, TJ Pemberton, X Meng, YJ Jin, YJ Jin   +43 more
core   +2 more sources

A cDNA Clone for Cyclophilin from Griffithsia japonica and Phylogenetic Analysis of Cyclophilins

Molecules and Cells, 2002
A cDNA clone, designated as Griffithsia japonica cyclophilin-1 (GjCyp-1), was isolated by differential screening of a cDNA library for a red alga, G. japonica. The transcript that corresponded to GjCyp-1 was abundant in vegetative, male, and tetrasporangial thalli, but only the basal level of the transcript was detected in female gametophytes ...
Yoo Kyung, Lee, Choo Bong, Hong, Youngbae, Suh, In Kyu, Lee   +3 more
openaire   +2 more sources

Molecular Mechanisms Underlying Root Nodule Formation and Activity

Agronomy
Symbiotic interactions between legumes and a group of soil bacteria, known as rhizobia, lead to the formation of a specialized organs called root nodules.
Katarzyna Nuc, Przemysław Olejnik
doaj   +1 more source