Results 181 to 190 of about 3,458 (212)
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Cyclophilin of Schistosoma japonicum
The Journal of Parasitology, 1992A 623-bp cDNA molecule encoding cyclophilin, a specific cyclosporin A-binding protein, has been isolated from Schistosoma japonicum using a heterologous cDNA probe from Echinococcus granulosus. The nucleotide sequence of this molecule has been determined, and the deduced amino acid sequence has revealed extensive homology with homologues of other ...
V P, Argaet, G F, Mitchell
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Sequence conservation of schistosome cyclophilins
Molecular and Biochemical Parasitology, 1996Sequence conservation of schistosome ...
Mo-Quen Klinkert +2 more
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Clinics in Liver Disease, 2009
The percentage of patients chronically infected with hepatitis C virus (HCV) who have reached sustained antiviral response has increased since the introduction of the pegylated interferon-alpha (pIFNa) and ribavirin (RBV) treatment. However, the current standard pIFNa/RBV therapy not only has a low success rate (about 50%) but is often associated with ...
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The percentage of patients chronically infected with hepatitis C virus (HCV) who have reached sustained antiviral response has increased since the introduction of the pegylated interferon-alpha (pIFNa) and ribavirin (RBV) treatment. However, the current standard pIFNa/RBV therapy not only has a low success rate (about 50%) but is often associated with ...
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Structure of recombinant human cyclophilin J, a novel member of the cyclophilin family
Acta Crystallographica Section D Biological Crystallography, 2005Cyclophilins (CyPs) are a large class of highly conserved ubiquitous peptidyl-prolyl cis-trans isomerases. CyPs have also been identified as being a specific receptor for the immunosuppressive drug cyclosporin A and are involved in a variety of biological functions.
Li Li, Huang +4 more
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Cyclophilins: Proteins in search of function [PDF]
Plant Signaling and Behavior, 2013 Cyclophilins constitute a subgroup of large family of proteins called immunophilins, which also include FKBPs and Parvulins. They are remarkably conserved in all genera, highlighting their pivotal role in important cellular processes. Most cyclophilins display PPIase enzymatic activity, multiplicity, diverse cellular locations and active role in ...
Sumita Kumari +2 more
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Role of Cyclophilins in Somatolactogenic Action
Annals of the New York Academy of Sciences, 2000Abstract: Prolactin (PRL) and growth hormone (GH) are members of the somatolactogenic hormone family, the pleiotropic actions of which are necessary for vertebrate growth and mammary differentiation. The basis for the specific function of these hormones has remained uncertain; however, their action is associated with internalization and translocation ...
M A, Rycyzyn, C V, Clevenger
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Oligopeptide cyclophilin inhibitors: A reassessment
European Journal of Medicinal Chemistry, 2011Potent cyclophilin A (CypA) inhibitors such as non-immunosuppressive cyclosporin A (CsA) derivatives have been already used in clinical trials in patients with viral infections. CypA is a peptidyl prolyl cis/trans isomerase (PPIase) that catalyzes slow prolyl bond cis/trans interconversions of the backbone of substrate peptides and proteins.
Michael, Schumann +4 more
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Functional aspects of extracellular cyclophilins
Biological Chemistry, 2014Abstract The cyclophilin family of peptidyl prolyl cis/trans isomerases includes several isoforms found to be secreted in response to different stimuli, thus existing both in the interior and the exterior of cells. The extracellular fractions of the cyclophilins CypA and CypB are involved in the control of cell-cell communication.
Henrik, Hoffmann +1 more
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Role of Cyclophilin A in HIV Replication
Future Virology, 2006A review. More than a decade has passed since the discovery that the peptidyl prolyl isomerase cyclophilin A (CypA) specifically binds to a proline-rich sequence in HIV-1 capsid (CA) and is thereby incorporated into viral particles. Since then, a variety of possible functions of CypA in the HIV-1 replication cycle have been intensively investigated ...
Votteler, J., Wray, V., Schubert, U.S.
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Cyclophilin D as a Drug Target
Current Medicinal Chemistry, 2003The mitochondrial permeability transition (MPT) plays an important role in damage-induced cell death, and agents inhibiting the MPT may have a therapeutic potential for treating human conditions such as ischemia/reperfusion injury, trauma, and neurodegenerative diseases.
Peter C, Waldmeier +4 more
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