Results 191 to 200 of about 4,905 (211)
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Clinics in Liver Disease, 2009
The percentage of patients chronically infected with hepatitis C virus (HCV) who have reached sustained antiviral response has increased since the introduction of the pegylated interferon-alpha (pIFNa) and ribavirin (RBV) treatment. However, the current standard pIFNa/RBV therapy not only has a low success rate (about 50%) but is often associated with ...
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The percentage of patients chronically infected with hepatitis C virus (HCV) who have reached sustained antiviral response has increased since the introduction of the pegylated interferon-alpha (pIFNa) and ribavirin (RBV) treatment. However, the current standard pIFNa/RBV therapy not only has a low success rate (about 50%) but is often associated with ...
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Cyclophilin of Schistosoma japonicum
The Journal of Parasitology, 1992A 623-bp cDNA molecule encoding cyclophilin, a specific cyclosporin A-binding protein, has been isolated from Schistosoma japonicum using a heterologous cDNA probe from Echinococcus granulosus. The nucleotide sequence of this molecule has been determined, and the deduced amino acid sequence has revealed extensive homology with homologues of other ...
V P, Argaet, G F, Mitchell
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Sequence conservation of schistosome cyclophilins
Molecular and Biochemical Parasitology, 1996Sequence conservation of schistosome ...
Klinkert Mq +4 more
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Functional aspects of extracellular cyclophilins
Biological Chemistry, 2014Abstract The cyclophilin family of peptidyl prolyl cis/trans isomerases includes several isoforms found to be secreted in response to different stimuli, thus existing both in the interior and the exterior of cells. The extracellular fractions of the cyclophilins CypA and CypB are involved in the control of cell-cell communication.
Henrik, Hoffmann +1 more
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Oligopeptide cyclophilin inhibitors: A reassessment
European Journal of Medicinal Chemistry, 2011Potent cyclophilin A (CypA) inhibitors such as non-immunosuppressive cyclosporin A (CsA) derivatives have been already used in clinical trials in patients with viral infections. CypA is a peptidyl prolyl cis/trans isomerase (PPIase) that catalyzes slow prolyl bond cis/trans interconversions of the backbone of substrate peptides and proteins.
Michael, Schumann +4 more
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Structure of recombinant human cyclophilin J, a novel member of the cyclophilin family
Acta Crystallographica Section D Biological Crystallography, 2005Cyclophilins (CyPs) are a large class of highly conserved ubiquitous peptidyl-prolyl cis-trans isomerases. CyPs have also been identified as being a specific receptor for the immunosuppressive drug cyclosporin A and are involved in a variety of biological functions.
Li Li, Huang +4 more
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Plant cyclophilins and Agrobacterium
Trends in Plant Science, 1998Abstract Deng, W., Chen, L., Wood, D.W., Metcalfe, T., Liang, X., Gordon, M.P., Comai, L. and Nester, E.W. (1998) Agrobacterium VirD2 protein interacts with plant host cyclophilins, Proc. Natl. Acad. Sci. U. S. A .
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2020
Using a combination of genetic and drug-based approaches, this thesis identified distinct roles for two members of the cyclophilin family of proteins in causing cell death and inducing inflammation in models of acute and chronic kidney disease.
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Using a combination of genetic and drug-based approaches, this thesis identified distinct roles for two members of the cyclophilin family of proteins in causing cell death and inducing inflammation in models of acute and chronic kidney disease.
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