Lactobacillus johnsonii attenuates ovarian aging by remodeling the gut–ovary axis
iMetaOmics, EarlyView.Aging is accompanied by a reduced abundance of L. johnsonii and ovarian decline. Supplementation with L. johnsonii elevates microbial IPA production via the LdhA enzyme and commensal bacteria. IPA activates the AhR/YAP signaling axis, promoting YAP nuclear translocation and inducing the expression of downstream target genes CYR61 and CTGF. This cascade
Jiamin He +16 more
wiley +1 more source
Adriamycin/cyclophosphamide combination chemotherapy: The importance of drug scheduling
, 1979 The effect of adriamycin/cyclophosphamide combination chemotherapy was evaluated against a spectrum of transplantable tumours in mice (L1210 leukaemia, Lewis lung carcinoma and C22LR osteosarcoma) and critical normal tissue.
Putten, L.M. van, Mulder, J.H.
core
JPGN Reports, EarlyView.Abstract The rising incidence of pediatric Clostridioides difficile infection (CDI), particularly in medically complex patients, calls for novel, individualized treatments. While fecal microbiota transplantation (FMT) is well‐described for recurrent CDI, this report describes the first pediatric case of fulminant CDI with toxic megacolon successfully ...
Dana McCarney +3 more
wiley +1 more source
Protodioscin mitigates cyclophosphamide-induced renal toxicity in HEK-293 cells by regulating endoplasmic reticulum stress, antioxidant defense, and apoptotic pathways. [PDF]
PLoS OneAhmadi AR +4 more
europepmc +1 more source
Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives
JSFA reports, EarlyView.Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz +10 more
wiley +1 more source
Ewing's Sarcoma in Adults: A Predictive Nomogram and Survival Analysis of a Cohort of 937 Patients
Journal of Surgical Oncology, EarlyView.ABSTRACT Background Ewing sarcoma is a rare malignancy of bone and soft tissue that most commonly affects children, adolescents, and young adults. Although multimodal treatment has improved survival in localised disease, outcomes remain poorer in adults, particularly in those with metastatic disease, larger tumours, or anatomically complex primary ...
Jonathan Gibson +6 more
wiley +1 more source
Nail Toxicities Associated With Anticancer Therapies in Children
JEADV Clinical Practice, EarlyView.ABSTRACT Nail toxicities are a frequent yet often underrecognized component of dermatologic adverse events in children receiving anticancer therapies. Both conventional cytotoxic chemotherapy and newer targeted agents can affect the nail matrix, nail bed and periungual tissues, producing a broad spectrum of clinical manifestations that range from ...
Luca Rapparini, Michela Starace
wiley +1 more source
New CT-Detected Pulmonary Abnormalities During Breast Cancer Chemotherapy: Frequency, Imaging Features, and Cumulative-Exposure Associations. [PDF]
Cancers (Basel)Zhao J +6 more
europepmc +1 more source
A Case of Systemic Amyloidosis Diagnosed After Excision of a Cutaneous Tumour of the Buttocks
JEADV Clinical Practice, EarlyView.ABSTRACT A 72‐year‐old Japanese man was referred to our hospital with two tumours on the buttocks. Two solitary, 2.5 × 1.5 cm‐sized, dark brown, well‐demarcated elevated plaques were observed, one on each side of the gluteal cleft, and dermoscopic examination showed comedo‐like openings, multiple milia‐like cysts, and a cerebriform pattern with ...
Tomomichi Shimizu +9 more
wiley +1 more source