Results 11 to 20 of about 378,238 (343)

Rapamycin Prevents cyclophosphamide-induced Over-activation of Primordial Follicle pool through PI3K/Akt/mTOR Signaling Pathway in vivo

Journal of Ovarian Research, 2017
BackgroundPrimordial follicular depletion has thought to be a common adverse effect of chemotherapy especially for female of reproductive age. The study aimed to evaluate the protective effect of rapamycin on the primordial follicles and its potential ...
Linyan Zhou, Yanqiu Xie, Song Li, Yihua Liang, Q. Qiu, Haiyan Lin, Qingxue Zhang   +6 more
semanticscholar   +3 more sources

Fish oil enhanced the efficacy of low-dose cyclophosphamide regimen for proliferative lupus nephritis: a randomized controlled double-blind trial

Food & Nutrition Research, 2021
Background: Lupus nephritis (LN) is one of the most severe organ that damages the systemic lupus erythematosus (SLE). Cyclophosphamide is one of the main drugs used in the treatment of LN.
Chi Zhang, Chang Ge, Junsheng Wang, Dong Sun   +3 more
doaj   +1 more source

Cytochrome P450 Oxidoreductase Influences CYP2B6 Activity in Cyclophosphamide Bioactivation. [PDF]

PLoS ONE, 2015
Cyclophosphamide is commonly used as an important component in conditioning prior to hematopoietic stem cell transplantation, a curative treatment for several hematological diseases.
Ibrahim El-Serafi, Parvaneh Afsharian, Ali Moshfegh, Moustapha Hassan, Ylva Terelius   +4 more
doaj   +1 more source

Pharmacokinetics and Pharmacogenetics of Cyclophosphamide in a Neonate and Infant Childhood Cancer Patient Population

Pharmaceuticals, 2021
Infants and young children represent an important but much understudied childhood cancer patient population. The pharmacokinetics and pharmacogenetics of the widely used anticancer prodrug cyclophosphamide were investigated in children
Shelby Barnett, Julie Errington, Julieann Sludden, David Jamieson, Vianney Poinsignon, Angelo Paci, Gareth J. Veal   +6 more
doaj   +1 more source

A Study on the Alteration of Endoplasmic Reticulum Stress-related Proteins in Cyclophosphamide-induced Damage to Urothelium [PDF]

Pharmaceutical and Biomedical Research, 2023
Background: Cyclophosphamide is widely prescribed as an anti-cancer drug and used as an immunosuppressant. Hemorrhagic cystitis is one of the common complications of cyclophosphamide intake.
Hemalatha R, Muthuraman N, Sandya Rani, Premila Abraham   +3 more
doaj  

The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in rats [PDF]

Acta Cirúrgica Brasileira, 2018
Purpose: To evaluate the impact of systemic cyclophosphamide treatment on the rat uterus and investigate the potential therapeutic effects of natural antioxidant preparations curcumin and capsaicin against cyclophosphamide side effects.
Ercan Yilmaz, Rauf Melekoglu, Osman Ciftci, Sevil Eraslan, Asli Cetin, Nese Basak   +5 more
doaj   +1 more source

Administration of cyclophosphamide to rats induces pica and potentiates 5-hydroxytryptamine synthesis in the intestine without causing severe intestinal injury

Journal of Pharmacological Sciences, 2021
The effects of cyclophosphamide on 5-hydroxytryptamine (5-HT) synthesis in the intestinal tissue of rats were investigated. Rats received 120 mg/kg cyclophosphamide intraperitoneally as a single administration, and kaolin and food intake was measured by ...
Akihisa Kamiya, Takuji Machida, Megumi Hirano, Maiko Machida, Saki Shiga, Naoya Hamaue, Masahiko Hirafuji, Kenji Iizuka   +7 more
doaj   +1 more source

Cyclophosphamide added to glucocorticoids in acute exacerbation of idiopathic pulmonary fibrosis (EXAFIP): a randomised, double-blind, placebo-controlled, phase 3 trial.

The Lancet Respiratory Medicine, 2021
BACKGROUND The use of cyclophosphamide in patients with acute exacerbation of idiopathic pulmonary fibrosis (IPF) is unknown. Our study was designed to evaluate the efficacy and safety of four cyclophosphamide pulses in addition to high-dose ...
J. Naccache, S. Jouneau, M. Didier, R. Borie, M. Cachanado, A. Bourdin, M. Reynaud‐Gaubert, P. Bonniaud, D. Israëł-Biet, G. Prévôt, S. Hirschi, F. Lebargy, S. Marchand-Adam, N. Bautin, J. Traclet, E. Gomez, S. Leroy, F. Gagnadoux, F. Rivière, E. Bergot, A. Gondouin, E. Blanchard, A. Parrot, F. Blanc, A. Chabrol, S. Dominique, A. Gibelin, A. Tazi, L. Berard, P. Brillet, M. Debray, Alexandra Rousseau, M. Kerjouan, O. Freynet, M. Dombret, A. Gamez, A. Nieves, G. Beltramo, J. Pastre, A. Le Borgne-Krams, T. Dégot, C. Launois, L. Plantier, L. Wémeau-Stervinou, J. Cadranel, C. Chenivesse, D. Valeyre, B. Crestani, V. Cottin, T. Simon, H. Nunes   +50 more
semanticscholar   +1 more source

Cyclophosphamide alters the gene expression profile in patients treated with high doses prior to stem cell transplantation. [PDF]

PLoS ONE, 2014
BACKGROUND: Hematopoietic stem cell transplantation is a curative treatment for several haematological malignancies. However, treatment related morbidity and mortality still is a limiting factor.
Ibrahim El-Serafi, Manuchehr Abedi-Valugerdi, Zuzana Potácová, Parvaneh Afsharian, Jonas Mattsson, Ali Moshfegh, Moustapha Hassan   +6 more
doaj   +1 more source

Nephrotoxicity Risk of Cyclophosphamide in Lupus Model

Journal of Tropical Pharmacy and Chemistry, 2021
Cyclophosphamide is one of the standard therapies for lupus, especially lupus nephritis based on its immunosuppressive effect. However, cyclophosphamide is also known as a nephrotoxic agent.
Niken Indriyanti
doaj   +1 more source