Results 41 to 50 of about 154,825 (291)

Functional immunomics: Microarray analysis of IgG autoantibody repertoires predicts the future response of NOD mice to an inducer of accelerated diabetes [PDF]

, 2004
One's present repertoire of antibodies encodes the history of one's past immunological experience. Can the present autoantibody repertoire be consulted to predict resistance or susceptibility to the future development of an autoimmune disease? Here we developed an antigen microarray chip and used bioinformatic analysis to study a model of type 1 ...
arxiv   +1 more source

Early skeletal muscle deconditioning and reduced exercise capacity during (neo)adjuvant chemotherapy in patients with breast cancer

Cancer, Volume 129, Issue 2, Page 215-225, 15 January 2023., 2023
Abstract Background Fatigue is a hallmark of breast cancer and is associated with skeletal muscle deconditioning. If cancer‐related fatigue occurs early during chemotherapy (CT), the development of skeletal muscle deconditioning and its effect on exercise capacity remain unclear. The aim of this study was to investigate the evolution of skeletal muscle
Joris Mallard, Elyse Hucteau, Roland Schott, Philippe Trensz, Carole Pflumio, Michal Kalish‐Weindling, Fabrice Favret, Xavier Pivot, Thomas J. Hureau, Allan F. Pagano   +9 more
wiley   +1 more source

Efficacy of two intensive decontamination protocols and their effects after 30 days on environmental contamination by cyclophosphamide

Pharmaceutical Technology in Hospital Pharmacy, 2021
To evaluate the efficacy of two decontamination protocols on cyclophosphamide surface contamination and to explore its lasting effect 30 days later.
Delafoy Clémence, Chabut Claire, Tanguay Cynthia, Bussières Jean-François   +3 more
doaj   +1 more source

Development and validation of a UPLC-MS/MS method with volumetric absorptive microsampling to quantitate cyclophosphamide and 4-hydroxycyclophosphamide

Frontiers in Pharmacology, 2022
Cyclophosphamide (CP) is an anti-cancer alkylating prodrug, metabolized by CYP450 into its active metabolite 4-hydroxycyclophosphamide (4-OHCP). Its therapeutic effectiveness is determined by the 4-OHCP concentration. Several analytical methods in plasma
Yahdiana Harahap, Yahdiana Harahap, Steven Steven, Herman Suryadi   +3 more
doaj   +1 more source

The demographic attributes, clinical features, and optimal management of 143 patients with pemphigus: A retrospective observational study from a tertiary care center of India

Indian Dermatology Online Journal, 2022
Background: This retrospective study was to understand the clinico-epidemiologic and therapeutic aspects of pemphigus patients attending our clinic. Methods: We analyzed charts of 143 (M: F; 51:92) pemphigus patients having variable severity recorded ...
Vikram K Mahajan, Karaninder S Mehta, Jyotshna Sharma, Prabal Kumar, Pushpinder S Chauhan, Ravinder Singh, Sujaya Manvi, Sanket Vashist, Anuj Sharma, Anju L Sharma   +9 more
doaj   +1 more source

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

Molecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
wiley   +1 more source

Administration of cyclophosphamide to rats induces pica and potentiates 5-hydroxytryptamine synthesis in the intestine without causing severe intestinal injury

Journal of Pharmacological Sciences, 2021
The effects of cyclophosphamide on 5-hydroxytryptamine (5-HT) synthesis in the intestinal tissue of rats were investigated. Rats received 120 mg/kg cyclophosphamide intraperitoneally as a single administration, and kaolin and food intake was measured by ...
Akihisa Kamiya, Takuji Machida, Megumi Hirano, Maiko Machida, Saki Shiga, Naoya Hamaue, Masahiko Hirafuji, Kenji Iizuka   +7 more
doaj  

Cavitary lung opacity of unusual cause during Behçet disease

Clinical Case Reports, 2022
Pulmonary artery aneurysm must be evoked in front of any hemoptysis in a patient with Behçet disease as it requires urgent immunosuppressive therapy and often surgery.
Donia Chebbi, Chifa Damak, Faten Frikha, Walid Abid, Mohamed Rebai, Mouna Snoussi, Raida Ben Salah, Sameh Marzouk, Abdessalem Hentati, Zouhir Bahloul   +9 more
doaj   +1 more source

Effects of collagen peptides from Micropterus salmoides skin on oxidative damage induced by cyclophosphamide in mice

Frontiers in Nutrition, 2022
To investigate the protective effect of collagen peptide from Micropterus salmoides skin (CPMs) on oxidative damage induced by cyclophosphamide in mice.
Mengyao Han, Zhongshan Zhang, Xinyue Li, Haibin Tong, Zhiguo Xu, Zikang Ding, Anquan Yang, Min Xie, Xiaomei Wang   +8 more
doaj   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source