Results 61 to 70 of about 19,882 (280)

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo [PDF]

, 2013
Whole-cell catalysts for non-natural chemical reactions will open new routes to sustainable production of chemicals. We designed a cytochrome 'P411' with unique serine-heme ligation that catalyzes efficient and selective olefin cyclopropanation in intact
A Vagin, AJ Dunford, Arvind Kannan, CJ Reedy, DA Evans, DC Haines, DS Wuttke, Eric M Brustad, Frances H Arnold, G Maas, GN Murshudov, H Lebel, HML Davies, JH Dawson, JR Wolf, KP Vatsis, LA Wessjohann, M Boyce, M Kataoka, Maraia E Ener, N Watanabe, P Emsley, P Evans, PD Adams, Pedro S Coelho, PJ Westfall, PK Ajikumar, PS Coelho, R Perera, S Bailey, Stefanie A Baril, T Omura, TWB Ost, W Kabsch, Z Jane Wang   +34 more
core   +3 more sources

Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations

Beilstein Journal of Organic Chemistry, 2012
Sequential cycloisomerizations of diynyl o-benzaldehyde substrates to access novel polycyclic cyclopropanes are reported. The reaction sequence involves initial Cu(I)-mediated cycloisomerization/nucleophilic addition to an isochromene followed by ...
Bo Leng, Stephanie Chichetti, Shun Su, Aaron B. Beeler, John A. Porco Jr.   +4 more
doaj   +1 more source

Transition-Metal-Free [3+2] Dehydration Cycloaddition of Donor-Acceptor Cyclopropanes With 2-Naphthols

Frontiers in Chemistry, 2021
A Brønsted acid-catalyzed domino ring-opening cyclization transformation of donor-acceptor (D-A) cyclopropanes and 2-naphthols has been developed.
Hua Zhao, Peng Shen, Dongru Sun, Hongbin Zhai, Yufen Zhao   +4 more
doaj   +1 more source

Cyclopropyl and cyclobutylboronates and silanes: A stereo­selective approach [PDF]

, 2018
Chiral cyclopropyl- and cyclobutylboronic esters and -silanes have become attractive intermediates for the preparation of functionalized small rings.
Martín-Heras, Víctor, Parra, Alejandro, Tortosa Manzanares, Mariola   +2 more
core   +1 more source

Scalable synthesis of (1-cyclopropyl)cyclopropylamine hydrochloride

Beilstein Journal of Organic Chemistry, 2011
1-Cyclopropylcyclopropanecarboxylic acid (2), which is accessible on a large scale (900 mmol) from 1-bromo-1-cyclopropylcyclopropane (1) in 64% yield (89% on a 12.4 mmol scale), has been subjected to a Curtius degradation employing the Weinstock protocol
Sergei I. Kozhushkov, Alexander F. Khlebnikov, Rafael R. Kostikov, Dmitrii S. Yufit, Armin de Meijere   +4 more
doaj   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

(2R,1'S,2'R)- and (2S,1'S,2'R)-3-[2-Mono(di,tri)fluoromethylcyclopropyl]alanines and their incorporation into hormaomycin analogues

Beilstein Journal of Organic Chemistry, 2014
Efficient and scalable syntheses of enantiomerically pure (2R,1'S,2'R)- and (2S,1'S,2'R)-3-[2-mono(di,tri)fluoromethylcyclopropyl]alanines 9a–c, as well as allo-D-threonine (4) and (2S,3R)-β-methylphenylalanine (3), using the Belokon' approach with (S ...
Armin de Meijere, Sergei I. Kozhushkov, Dmitrii S. Yufit, Christian Grosse, Marcel Kaiser, Vitaly A. Raev   +5 more
doaj   +1 more source

Levoglucosenone: Bio-Based Platform for Drug Discovery

Frontiers in Chemistry, 2022
Levoglucosone (LGO) is a bio-privileged molecule that can be produced on scale from waste biomass. This chiral building block has been converted via well-established chemical processes into previously difficult-to-synthesize building blocks such as ...
Jason E. Camp, Ben W. Greatrex
doaj   +1 more source

Biosynthesis of the Red Algal Diterpene Peyssonnosol in Bacteria

Angewandte Chemie International Edition, EarlyView.
Two terpene synthases derived from Anaerolineae bacteria catalyse the biosynthesis of peyssonnosene‐type diterpenes from red algae. Site‐directed mutagenesis enabled a partial functional switch, resulting in the formation of additional byproducts. The intricate cyclisation mechanisms were investigated through isotopic labelling experiments and density ...
Zhiyong Yin, Zhehui Hu, Kexin Yang, Guihu Lu, Georges B. Tabekoueng, Pingping Wu, Qi Luo, Juan Xu, Bernd Goldfuss, Jeroen S. Dickschat, Guangkai Bian   +10 more
wiley   +1 more source

Dirhodium(II)-catalyzed [3 + 2] cycloaddition of N-arylaminocyclopropane with alkyne derivatives

Beilstein Journal of Organic Chemistry, 2019
Dirhodium(II) complex-catalyzed [3 + 2] reactions between N-arylaminocyclopropanes and alkyne derivatives are described. The cycloaddition products proved to be versatile synthetic intermediates.
Wentong Liu, Yi Kuang, Zhifan Wang, Jin Zhu, Yuanhua Wang   +4 more
doaj   +1 more source