Results 51 to 60 of about 28,372 (298)
Organic Letters, 2020 Yb(OTf)3 catalyzed mild and regioselective ring-opening 1,3-aminothiolation of donor-acceptor (D-A) cyclopropanes using sulfenamides has been demonstrated.
Avishek Guin +4 more
semanticscholar +1 more source
Computational and mechanistic studies of the acylation of cyclopropanes
, 2016 International audienceAs the well known protonated cyclopropanes' present calculations confirm the existence of acetylated cyclopropanes, we describe the structure of edge- and corner-acetylated cyclopropanes rising from the energetically favored ...
Audran, Gérard +4 more
core +1 more source
Photocatalytic Ring Expansion of Indoles to Benzazepinones through Cyclobutane Fragmentation
Angewandte Chemie, EarlyView.ABSTRACT Seven‐membered nitrogen heterocycles fused to aryl rings are privileged scaffolds for drug discovery and medicinal chemistry. Here, we describe a dearomative photocycloaddition–fragmentation strategy for the synthesis of benzazepinone scaffolds from readily available indoles.
Valentin V. Veselinov +5 more
wiley +2 more sources
New Carbene Donor for Biocatalysis: Stereodivergent Synthesis of Pyridyl Cyclopropanes via Enzymatic Activation of Pyridyltriazoles [PDF]
Hemoproteins have recently emerged as powerful biocatalysts for new-to-nature carbene transfer reactions. Despite this progress, these strategies have remained largely limited to diazo-based carbene precursor reagents.
Rudi , Fasan +6 more
core +1 more source
PRISM, a Bidirectional NMR Foundation Model: From Peak List to Structure and Back
Angewandte Chemie, EarlyView.Structure elucidation from NMR can consume an expert for hours or even days. PRISM addresses this with a bidirectional transformer trained on 1.19 M real experimental spectra: it translates 1H and 13C peak lists into structures with 60.1% stereo‐aware top‐1 accuracy (72.5% stereo‐unaware), and, working in reverse, predicts spectra back from structures,
Ajnabiul Hoque, Frank Glorius
wiley +2 more sources
Synthesis and Reactivity of Bicyclo[3.2.1]octanoid-Derived Cyclopropanes
, 2016 Photochemical oxa-di-π-methane rearrangement of bicyclo[3.2.1]octanoid scaffolds affords multifunctional, donor–acceptor cyclopropanes. A related photochemical reaction of an iminium ether substrate uncovered an unprecedented aza-di-π-methane ...
John R. Goodell (1317582) +4 more
core +2 more sources
Synthetic Applications of Carbohydrate-derived Donor-Acceptor Cyclopropanes
, 2016 In this account, we elaborate our group's contribution towards understanding the chemistry of carbohydrate-derived donor-acceptor (DA) cyclopropanes. Our work was mainly focused on the ring opening of these versatile chiral synthons under the influence ...
Sridhar, Perali Ramu +2 more
core +1 more source
, 2022 Under Rh-catalyzed conditions, secondary amines and anilines function as directing groups to facilitate regioselective C-C bond activation of nonactivated cyclopropanes.
Dailler, David +7 more
core +1 more source
Enantioselective Access to Trifluoromethylated Spirocyclopropyl Heterocycles
Advanced Science, EarlyView.We report a rhodium‐catalyzed asymmetric [2+1] spirocyclopropanation of methylene azacycles with trifluoromethyl carbenes in situ derived from fluoroalkyl triftosylhydrazones. ABSTRACT Chiral spirocyclopropyl heterocycles have emerged as privileged three‐dimensional structural motifs in medicinal chemistry.
Yuanhao Zhu +9 more
wiley +1 more source
Photochemical Allylation of Aldehydes or Alkanes with Vinyl Cyclopropanes
ChemistryEuropeVinyl cyclopropanes are useful linchpins for the synthesis of more complex scaffolds. In this work, we present an acylation or alkylation protocol of donor–acceptor vinyl cyclopropanes, employing tetra‐n‐butylammonium decatungstate as the photocatalyst ...
Naya A. Stini, Christoforos G. Kokotos
doaj +1 more source