Results 31 to 40 of about 28,372 (298)

Photocatalyzed Diastereoselective Isomerization of Cinnamyl Chlorides to Cyclopropanes

Journal of the American Chemical Society, 2020
Endergonic isomerizations are thermodynamically unfavored processes that are difficult to realize under thermal conditions. We report a photocatalytic diastereoselective isomerization of acyclic cinnamyl chlorides to strained cyclopropanes.
Bin Xu, Ludovic Troian-Gautier, Ryan Dykstra, Robert T. Martin, O. Gutierrez, U. Tambar   +5 more
semanticscholar   +1 more source

Copper, Boron and Vinyl Epoxides: from 1,4-Diols to Cyclopropylboronates

CHIMIA, 2020
Herein we describe the reactivity found between vinyl epoxides and catalytically generated copper-boryl complexes. By tuning the substituents of the alkene and/or the reaction conditions, 1,4-diols, allylic alcohols or cyclopropylboronates can be ...
Luis Novoa, Laura Trulli, Alejando Parra, Mariola Tortosa   +3 more
doaj   +1 more source

Preparation of Chiral Enantioenriched Densely Substituted Cyclopropyl Azoles, Amines, and Ethers via Formal S_N2′ Substitution of Bromocylopropanes

Molecules, 2022
Enantiomerically enriched cyclopropyl ethers, amines, and cyclopropylazole derivatives possessing three stereogenic carbon atoms in a small cycle are obtained via the diastereoselective, formal nucleophilic substitution of chiral, non-racemic ...
Hillary Straub, Pavel Ryabchuk, Marina Rubina, Michael Rubin   +3 more
doaj   +1 more source

Access to Divergent Fluorinated Enynes and Arenes via Palladium-Catalyzed Ring-Opening Alkynylation of gem-Difluorinated Cyclopropanes.

Organic Letters, 2020
Herein, we describe a palladium-catalyzed alkynylation of gem-difluorinated cyclopropanes via C-C bond activation/C-F bond cleavage, followed by C-C(sp) coupling.
Ebrahim-Alkhalil M. A. Ahmed, A. Suliman, Tian-Jun Gong, Yao Fu   +3 more
semanticscholar   +1 more source

Olefin Cyclopropanations via Sequential Atom Transfer Radical Addition-Dechlorination Reactions

CHIMIA, 2010
In organic synthesis, cyclopropanation reactions are often performed with Simmons–Smith-type reagents or by transition metal catalyzed reactions of olefins with diazo compounds.
Katrin Thommes, Kay Severin
doaj   +1 more source

Synthesis and Evaluation of Biological Activities of Bis(spiropyrazolone)cyclopropanes: A Potential Application against Leishmaniasis

Molecules, 2021
This work focuses on the search and development of drugs that may become new alternatives to the commercial drugs currently available for treatment of leishmaniasis. We have designed and synthesized 12 derivatives of bis(spiropyrazolone)cyclopropanes. We
Olalla Barreiro-Costa, Gabriela Morales-Noboa, Patricio Rojas-Silva, Eliana Lara-Barba, Javier Santamaría-Aguirre, Natalia Bailón-Moscoso, Juan Carlos Romero-Benavides, Ana Herrera, Cristina Cueva, Lenin Ron-Garrido, Ana Poveda, Jorge Heredia-Moya   +11 more
doaj   +1 more source

Green and Facile Synthesis of Spirocyclopentanes Through NaOH-Promoted Chemo- and Diastereo-Selective (3 + 2) Cycloaddition Reactions of Activated Cyclopropanes and Enamides

Frontiers in Chemistry, 2020
A chemo- and diastereo-selective (3 + 2) cycloaddition reacition between Donor-Acceptor (D-A) cyclopropanes and α,β-unsaturated enamides is developed for efficient access to spiro(cyclopentane-1,3'-indoline) derivatives.
Xun Zhu, Dingwu Pan, Chengli Mou, Bo Zhou, Lutai Pan, Zhichao Jin   +5 more
doaj   +1 more source

Ring-Opening Hydroarylation of Monosubstituted Cyclopropanes Enabled by Hexafluoroisopropanol [PDF]

, 2018
Ring-opening hydroarylation of cyclopropanes is typically limited to substrates bearing a donor-acceptor motif. Here, the transformation is achieved for monosubstituted cyclopropanes by using catalytic Brønsted acid in hexafluoroisopropanol (HFIP ...
Christopher, Rowley, Jing, Yi, Edward, Richmond, Fatima, Sajadi, Vuk D., Vuković, Joseph, Moran   +5 more
core   +2 more sources

1‐Azabicyclo[1.1.0]butanes (ABBs) on the Map: Mechanistic Pathways for Catalytic Ring Opening and Functionalizations

Angewandte Chemie, EarlyView.
Catalytic strain‐release ring opening and functionalizations of 1‐azabicyclo[1.1.0]butanes (ABBs) represent a promising strategy for accessing diverse azetidine products. These transformations proceed via polar pathways, radical pathways, and hybrid mechanisms that combine both.
James Shao‐Jiun Yang, Hsuan‐Hung Liao   +1 more
wiley   +2 more sources

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources