Results 21 to 30 of about 28,372 (298)
Molecules, 2022 We developed a straightforward synthetic route to pharmacologically important 1,5-substituted pyrrolidin-2-ones from donor–acceptor cyclopropanes bearing an ester group as one of the acceptor substituents.
Maksim A. Boichenko +9 more
doaj +1 more source
Donor‐Acceptor Cyclopropanes: Activation Enabled by a Single, Vinylogous Acceptor
Angewandte Chemie, 2022 A novel class of highly activated donor‐acceptor cyclopropanes bearing only a single, vinylogous acceptor is presented. These strained moieties readily undergo cycloadditions with aldehydes, ketones, thioketones, nitriles, naphth‐2‐ols and various other ...
Nils L Ahlburg +3 more
semanticscholar +1 more source
Angewandte Chemie, 2021 We present (3+2)‐ and (4+2)‐cycloadditions of donor–acceptor (D–A) cyclopropanes and cyclobutanes with N‐sulfinylamines and a sulfur diimide, along with a one‐pot, two‐step strategy for the formal insertion of HNSO2 into D–A cyclopropanes. These are rare
Gwyndaf A. Oliver +8 more
semanticscholar +1 more source
Continuous-Flow Synthesis of Arylthio-Cyclopropyl Carbonyl Compounds
Molecules, 2022 The straightforward, continuous-flow synthesis of cyclopropyl carbaldehydes and ketones has been developed starting from 2-hydroxycyclobutanones and aryl thiols.
Davide Moi +10 more
doaj +1 more source
Lewis Acid-Catalyzed Strain-Enabled (3+3) Annulation of Bicyclo[1.1.0]Butanes With Indolylalcohols: Synthesis of Indole-Fused Aza-Bicyclo[3.1.1]Heptanes. [PDF]
Adv Sci (Weinh)Bicyclo[1.1.0]butanes undergo a Lewis acid‐catalyzed formal (3 + 3) annulation with indolyl alcohols to furnish indole‐fused aza‐bicyclo[3.1.1]heptanes. Strain‐release‐driven C‐C bond formation, followed by C‐N bond formation via ring expansion, enables the rapid assembly of rigid, sp3‐rich bicyclic architectures under mild reaction conditions ...
Dey M +4 more
europepmc +2 more sources
Trifunktionelle Cyclopropane als Vorstufen von Triafulven und Calicen
CHIMIA, 1981 A series of 1,1-dihalo-2-X-cyclopropanes 3 have been prepared and characterised. Cyclopropanes of type 3 could be of interest as starting materials with respect to the attempted synthesis of triafulvene and calicene.
Andreas Weber +3 more
doaj +1 more source
Activation and Functionalization of C–C σ-Bonds of Alkylidene Cyclopropanes at Main Group Centers [PDF]
, 2020 Aluminum(I) and magnesium(I) compounds are reported for the C–C s-bond activation of strained alkylidene cyclopropanes. These reactions result in the formal addition of the C–C s-bond to main group center either at a single site (Al) or across a metal ...
Mark, Crimmin +5 more
core +3 more sources
Carbofluorination of Alkenes with gem-Difluorinated Cyclopropanes as Bifunctional Reagents Enabled by Well-Define Rhodium Catalysts [PDF]
, 2023 Herein, we report a Rh-catalyzed carbofluorination of alkenes using gem-difluorinated cyclopropanes as bifunctional reagents. The developed method tolerates a wide range of alkenes, providing access to secondary, tertiary fluorides and gem-difluorides ...
Ying, Xia +5 more
core +2 more sources
Molecules, 2014 The compounds [3-(2-Bromocyclohex-2-enyloxy)prop-1-ynyl]-tert-butyl-dimethylsilane 3, [4-(2-bromocyclohex-2-en-1-yloxy)but-2-yn-1-yloxy]tert-butyldimethylsilane 5 and dimethyl 2-(2-bromocyclohex-2-enyl)-2-(3-(tert-butyldimethylsilanyl)prop-2-ynyl ...
Aydin Demircan
doaj +1 more source
Pharmaceutics, 2023 In this work, we first improved the aqueous solubility of biologically active spiro[cyclopropane-1,3′-oxindoles] (SCOs) via their complexation with different β-cyclodextrins (β-CDs) and proposed a possible mechanism of the complex formation.
Anna A. Kravtsova +5 more
doaj +1 more source