Results 101 to 110 of about 82,661 (227)

Obesity Disrupts H3K4me3‐Mediated Lactate Accumulation and Efferocytosis in Hypoxic Macrophages

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Obesity disrupts macrophage adaptation to hypoxic microenvironments. In lean conditions, hypoxia induces H3K4me3‐dependent transcriptional programs that promote lactate accumulation, histone lactylation, and efficient efferocytosis. Diet‐induced obesity impairs this epigenetic–metabolic response, resulting in reduced lactate accumulation, defective ...
Kentaro Takahashi, Julia Drolet, Jinghua Liu, Jasmine R. Jackson, Madison Babcock, Muthusamy Thiruppathi, Milie Fang, Tyler Paul, Gayathri Ganesh, Yuri Fukasawa, Yoshikiyo Akasaka, Giamila Fantuzzi, Elizaveta V. Benevolenskaya, Timothy J. Koh, Norifumi Urao   +14 more
wiley   +1 more source

Hypertension, metabolic derangements and renal dysfunction in renal transplant patients using cyclosporine or tacrolimus

Brazilian Journal of Transplantation, 2006
Purpose: To assess metabolical and hypertension adverse events and renal function outcomes in patients with renal transplant receiving neoral cyclosporin or tacrolimus in an outpatient service in Brazil.
Luiz Estevam Ianhez, David José de Barros Machado   +1 more
doaj   +1 more source

Exploring Affordable Curative Therapy for Sickle Cell Disease in Africa: A Comprehensive Overview

American Journal of Hematology, Volume 101, Issue S1, Page 56-74, April 2026.
ABSTRACT The practical aspects of developing curative treatments for sickle cell disease (SCD) in Africa, such as gene therapy and hematopoietic stem cell transplantation, involve strengthening healthcare infrastructure, training healthcare professionals, establishing regional treatment centers, and creating national SCD programs.
Adetola A. Kassim, Alexis A. Thompson, Punam Malik   +2 more
wiley   +1 more source

Cyclosporin A Treatment in Psoriasis: Monitoring by Neopterin Concentrations In Serum and Urine

Pteridines, 1993
Psoriasis is a hyperproliferative skin disorder in which immune mechanisms are thought to play a role. Recently, cyclosporin A has been found effective to treat psoriasis. However, mechanisms of action of cyclosporin A in patients are not well understood.
Sepp N., Benedikter S., Kofler H., Fritsch P., Wachter H., Fuchs D.   +5 more
doaj   +1 more source

Effect of enzalutamide on anticoagulant therapy with edoxaban in patients with prostate cancer

British Journal of Clinical Pharmacology, Volume 92, Issue 4, Page 1117-1125, April 2026.
Aims Treatment with enzalutamide in prostate cancer is challenging due to its high potential for drug–drug interactions, particularly in the typically older population of patients with frequent comorbidities treated with multiple drugs, such as anticoagulants.
Catharina J. P. Op 't Hoog, Niven Mehra, Anouk van Kleef, Diederik M. Somford, Inge M. van Oort, Alex L. T. Imholz, Paul Hamberg, Nielka P. van Erp, Emmy Boerrigter   +8 more
wiley   +1 more source

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 891-904, April 2026.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi, Jessica L. Wallace, Dhakrit Rungkitwattanakul, Britney A. Stottlemyer, Tiffany L. Tran, Melanie Manis Reida, Sandra L. Kane‐Gill   +6 more
wiley   +1 more source

What Is Your Diagnosis? Cutaneous Mass in a Dog

Veterinary Clinical Pathology, EarlyView.
Ester Quilez, Shannon L. Donahoe
wiley   +1 more source

Tacrolimus Induced Hypertension and Vascular Remodeling Includes Mechanisms of Cellular Senescence—The Protective Effect of Valsartan

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Calcineurin inhibitors (CNI) such as tacrolimus (Tac) are the first‐line treatment to prevent transplant rejection. However, CNI have adverse effects on blood vessels and renal function, which may be linked to cellular senescence. Valsartan, a common angiotensin II type 1 receptor (AT1R) blocker, exhibits anti‐senescence properties.
Lingyan Fei, Xiaohua Wang, Lingyi Kong, Tianjiao Cui, Pratik H. Khedkar, Yunxiu Xiang, Dongliang Zhao, Junxuan Fang, Yulin Liang, Yangyang Zhang, Nan Xu, Xingyu Qiu, Liang Zhao, Gensheng Zhang, Yan Lei, Chun Tang, Kongyang Ma, Liwei Lu, Jin Wei, En Yin Lai, Pontus B. Persson, Andreas Patzak, Zhihua Zheng, Shan Jiang   +23 more
wiley   +1 more source

Unphysical Structure Collapse in Quantum Mechanics Calculations With Continuum Solvation

ChemPhysChem, Volume 27, Issue 5, 13 March 2026.
Quantum mechanics conformer searches with continuum solvation models yield preferably collapsed conformations not confirmed by sophisticated nuclear magnetic resonance (NMR) experiments. Continuum solvation force‐field and explicit solvation molecular dynamics simulations result preferably in stretched conformations, hinting on general weaknesses of ...
Andreas H. Göller, Dieudonné T. Tshitenge   +1 more
wiley   +1 more source

Preparation and in vitro and in vivo characterization of cyclosporin A-loaded, PEGylated chitosan-modified, lipid-based nanoparticles

International Journal of Nanomedicine, 2013
Ling Zhang,1,2,# Zhi-Liang Zhao,3,# Xiao-Hong Wei,1 Jin-Hua Liu21School of Medicine, 2College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, 3Tongde Hospital of Zhejiang Province, Hangzhou, People’s Republic of ...
Zhang L, Zhao Z-L, Wei X-H, Liu J-H
doaj