Results 91 to 100 of about 10,795 (199)

Cyclosporin a hepatotoxicity in 66 renal allograft recipients [PDF]

, 1981
Liver functional abnormalities were seen in 13 (19.7%) of 66 recipients of cadaveric renal homografts treated with cyclosporin A and prednisone. However, such presumed hepatotoxicity was a minor problem in the use of cyclosporin A.
Iwatsuki, S, Starzl, TE, Klintmalm, GBG
core   +1 more source

Adenine nucleotide translocator and ATP synthase cooperate in mediating the mitochondrial permeability transition

The Journal of Physiology, EarlyView.
Abstract figure legend Both ATP synthase and adenine nucleotide translocator (ANT) play key roles in mediating the permeability transition. The contribution of ANT becomes evident in the presence of atractylate (ATR) at pH 6.5, a condition that prevents ATP synthase channel activity. At pH 7.4, this effect is minimal, suggesting a critical role for ATP
Ludovica Tommasin, Andrea Carrer, Federica Boscolo Nata, Elena Frigo, Federico Fogolari, Giovanna Lippe, Michela Carraro, Paolo Bernardi   +7 more
wiley   +1 more source

Lessons to Learn From Low-Dose Cyclosporin-A: A New Approach for Unexpected Clinical Applications

Frontiers in Immunology, 2019
Cyclosporin-A has been known and used for a long time, since its “fast track” approval in the early 80's. This molecule has rapidly demonstrated unexpected immunosuppressive properties, transforming the history of organ transplantation. Cyclosporin's key
Camila Flores, Camila Flores, Guillemette Fouquet, Guillemette Fouquet, Ivan Cruz Moura, Ivan Cruz Moura, Thiago Trovati Maciel, Thiago Trovati Maciel, Olivier Hermine, Olivier Hermine, Olivier Hermine   +10 more
doaj   +1 more source

Distribution of cyclosporin in organ transplant recipients

, 2002
Cyclosporin is an immunosuppressive agent with a narrow therapeutic index. The total concentration of cyclosporin in blood is usually monitored to guide dosage adjustment and to compensate for substantial interindividual and intra-individual variability ...
Akhlaghi, Fatemeh, Trull, Andrew K.
core   +1 more source

Cyclosporine nephrotoxicity

Cleveland Clinic Journal of Medicine, 1989
Cyclosporine is a potent and useful immunosuppressive agent used primarily in conjunction with solid organ transplantation. The most serious adverse reaction that limits its use is nephrotoxicity due to effects on the renal vasculature, glomeruli, and tubular function. These effects result in a variety of clinical syndromes.
openaire   +2 more sources

Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury

The Journal of Physiology, EarlyView.
Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich, Ulas Ozkurede, Shanmugasundaram Pakkiriswami, Ryan Gemilere, Samira M. Azarin, Julia C. Liu   +5 more
wiley   +1 more source

Cyclosporin-associated thrombotic microangiopathy: Successful retreatment with cyclosporin. Ren Fail

, 1991
This report describes a patient whlo developed cyclosporin-induced thirombotic microangiopathy in a renal allograft. Cyclospolrin-induced thrombotic microangiopathy is considered by many as a contraindication to subsequent therapy with cyclosporin.
MD J Charles Jernnette, MD Stanley R Mandel, MD Paul Bolin Jr   +2 more
core  

Reduced kallikrein excretion by liposome-encapsulated cyclosporin in the rat

, 1993
Different phospholipids and methods of preparation were used to produce cyclosporin encapsulated in liposomes. The optimal formulation of cyclosporin-liposome was compared to the oily cyclosporin after intraperitoneal administration of 25 mg kg−1 body ...
Rashad Tawashi, Fabien Legris, Mostafa Akbarieh, Albert Adam   +3 more
core   +1 more source

A primary cell‐based fluidic co‐culture model to investigate drug transport across the human placenta

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of a flow‐driven in vitro model of the human placental barrier designed to study transport processes during pregnancy. The model recreates key features of the maternal–fetal interface, enabling the investigation of how nutrients and therapeutic compounds cross the placental barrier under physiologically ...
Barbara Fuenzalida, Nadja Koechli, Edgar Ontsouka, Chennakesava Cuddapah, Martin Mueller, Bram Sengers, Frantisek Staud, Christiane Albrecht   +7 more
wiley   +1 more source

Cyclosporin A therapy for severe solar urticaria

, 1997
Solar urticaria is characterized by itching weals that occur a few minutes after exposure to visible or ultraviolet light. The symptoms may sometimes restrict normal daily life. Treatment is difficult in more severe cases.
D. W. Edström, Wiegleb Edström, Desirée,, Ros, A. M.,, Ros, AM, A.-M. Ros, Edström, DW   +5 more
core   +1 more source